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Brains learn to represent information from a large set of stimuli, typically by weak supervision. Unsupervised learning is therefore a natural approach for exploring the design of biological neural networks and their computations.…

Neurons and Cognition · Quantitative Biology 2025-10-17 Roy Urbach , Elad Schneidman

Dense Associative Memories or Modern Hopfield Networks have many appealing properties of associative memory. They can do pattern completion, store a large number of memories, and can be described using a recurrent neural network with a…

Neural and Evolutionary Computing · Computer Science 2021-07-29 Dmitry Krotov

One of the challenges in Synthetic Biology is to design circuits with increasing levels of complexity. While circuits in Biology are complex and subject to natural tradeoffs, most synthetic circuits are simple in terms of the number of…

Optimization and Control · Mathematics 2014-03-03 Irene Otero-Muras , Julio R. Banga

Biology has changed radically in the last two decades, transitioning from a descriptive science into a design science. Synthetic biology allows us to bioengineer cells to synthesize novel valuable molecules such as renewable biofuels or…

Quantitative Methods · Quantitative Biology 2021-01-27 Tijana Radivojević , Zak Costello , Kenneth Workman , Hector Garcia Martin

Animals (especially humans) have an amazing ability to learn new tasks quickly, and switch between them flexibly. How brains support this ability is largely unknown, both neuroscientifically and algorithmically. One reasonable supposition…

Machine Learning · Computer Science 2017-06-23 Kevin T. Feigelis , Daniel L. K. Yamins

Nowadays, multiscale modelling is recognized as the most suitable way to study biological processes. Indeed, almost every phenomenon in nature exhibits a multiscale behaviour, i.e., it is the outcome of interactions that occur at different…

Formal Languages and Automata Theory · Computer Science 2011-08-18 Federico Buti , Massimo Callisto De Donato , Flavio Corradini , Emanuela Merelli , Luca Tesei

The emerging field of diverse intelligence seeks an integrated view of problem-solving in agents of very different provenance, composition, and substrates. From subcellular chemical networks to swarms of organisms, and across evolved,…

Artificial Intelligence · Computer Science 2026-02-04 Benedikt Hartl , Léo Pio-Lopez , Chris Fields , Michael Levin

Associative memories are data structures that allow retrieval of stored messages from part of their content. They thus behave similarly to human brain that is capable for instance of retrieving the end of a song given its beginning. Among…

Neural and Evolutionary Computing · Computer Science 2013-07-25 Bartosz Boguslawski , Vincent Gripon , Fabrice Seguin , Frédéric Heitzmann

Bio-digital systems that merge microbial life with technology promise new modes of computation, combining biological adaptability with digital precision. Yet realizing this potential symbiotically -- where biological and digital agents…

Human-Computer Interaction · Computer Science 2026-01-23 Zoë Breed , Elvin Karana , Alessandro Bozzon , Katherine W. Song

This article presents a spiking neuroevolutionary system which implements memristors as plastic connections, i.e. whose weights can vary during a trial. The evolutionary design process exploits parameter self-adaptation and variable…

Emerging Technologies · Computer Science 2012-12-17 Gerard Howard , Ella Gale , Larry Bull , Ben de Lacy Costello , Andy Adamatzky

Recently it has been demonstrated that causal entropic forces can lead to the emergence of complex phenomena associated with human cognitive niche such as tool use and social cooperation. Here I show that even more fundamental traits…

Information Theory · Computer Science 2016-04-20 Fouad Khan

Deep artificial neural networks famously struggle to learn from non-stationary streams of data. Without dedicated mitigation strategies, continual learning is associated with continuous forgetting of previous tasks and a progressive loss of…

Neurons and Cognition · Quantitative Biology 2025-12-29 Suzanne van der Veldt , Gido M. van de Ven , Sanne Moorman , Guillaume Etter

The field of artificial intelligence faces significant challenges in achieving both biological plausibility and computational efficiency, particularly in visual learning tasks. Current artificial neural networks, such as convolutional…

Machine Learning · Computer Science 2024-09-27 Jacobo Ruiz , Manas Gupta

In this survey, we examine algorithms for conducting credit assignment in artificial neural networks that are inspired or motivated by neurobiology. These processes are unified under one possible taxonomy, which is constructed based on how…

Neural and Evolutionary Computing · Computer Science 2023-12-27 Alexander G. Ororbia

Synaptic plasticity is the capacity of a preexisting connection between two neurons to change in strength as a function of neural activity. Because synaptic plasticity is the major candidate mechanism for learning and memory, the…

Neurons and Cognition · Quantitative Biology 2015-05-05 Maurizio De Pittà , Nicolas Brunel , Andrea Volterra

This work introduces a general multi-level model for self-adaptive systems. A self-adaptive system is seen as composed by two levels: the lower level describing the actual behaviour of the system and the upper level accounting for the…

Logic in Computer Science · Computer Science 2013-05-16 Emanuela Merelli , Nicola Paoletti , Luca Tesei

Cell signaling networks are complex and often incompletely characterized, making it difficult to obtain a comprehensive picture of the mechanisms they encode. Mathematical modeling of these networks provides important clues, but the models…

Molecular Networks · Quantitative Biology 2022-11-07 Soutick Saha , Hye-ran Moon , Bumsoo Han , Andrew Mugler

Adaptive simulated annealing (ASA) is a global optimization algorithm based on an associated proof that the parameter space can be sampled much more efficiently than by using other previous simulated annealing algorithms. The author's ASA…

Mathematical Software · Computer Science 2007-05-23 Lester Ingber

Animals learn to predict external contingencies from experience through a process of conditioning. A natural mechanism for conditioning is stimulus substitution, whereby the neuronal response to a stimulus with no prior behavioral…

Neurons and Cognition · Quantitative Biology 2024-09-23 Pantelis Vafidis , Antonio Rangel

Meta-learning aims to develop algorithms that can learn from other learning algorithms to adapt to new and changing environments. This requires a model of how other learning algorithms operate and perform in different contexts, which is…

Machine Learning · Computer Science 2023-05-23 Yuwei Sun