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Adaptive response to a varying environment is a common feature of biological organisms. Reproducing such features in electronic systems and circuits is of great importance for a variety of applications. Here, we consider memory models…

Cell Behavior · Quantitative Biology 2013-10-29 Fabio Lorenzo Traversa , Yuriy V. Pershin , Massimiliano Di Ventra

We present a benchmark study of autonomous, chemical agents exhibiting associative learning of an environmental feature. Associative learning has been widely studied in cognitive science and artificial intelligence, but are most commonly…

Adaptation and Self-Organizing Systems · Physics 2022-10-12 Stuart Bartlett , David Louapre

Learning in living organisms is typically associated with networks of neurons. The use of large numbers of adjustable units has also been a crucial factor in the continued success of artificial neural networks. In light of the complexity of…

Neurons and Cognition · Quantitative Biology 2024-05-10 Matthew Smart , Stanislav Y. Shvartsman , Martin Mönnigmann

Synthetic biology aims at designing modular genetic circuits that can be assembled according to the desired function. When embedded in a cell, a circuit module becomes a small subnetwork within a larger environmental network, and its…

Molecular Networks · Quantitative Biology 2019-01-14 Johannes Falk , Leo Bronstein , Maleen Hanst , Barbara Drossel , Heinz Koeppl

Several abilities of biological systems, such as adaptation to natural environment, or of animals to learn patterns when appropriately trained, are features that are extremely useful, if emulated by electronic circuits, in applications…

Neurons and Cognition · Quantitative Biology 2011-12-22 M. Di Ventra , Y. V. Pershin

We report a realization of an associative memory signal/information processing system based on simple enzyme-catalyzed biochemical reactions. Optically detected chemical output is always obtained in response to the triggering input, but the…

Molecular Networks · Quantitative Biology 2013-04-23 Vera Bocharova , Kevin MacVittie , Soujanya Chinnapareddy , Jan Halamek , Vladimir Privman , Evgeny Katz

When someone mentions the name of a known person we immediately recall her face and possibly many other traits. This is because we possess the so-called associative memory, that is the ability to correlate different memories to the same…

Neurons and Cognition · Quantitative Biology 2010-08-26 Yuriy V. Pershin , Massimiliano Di Ventra

Computation, mechanics and materials merge in biological systems, which can continually self-optimize through internal adaptivity across length scales, from cytoplasm and biofilms to animal herds. Recent interest in such material-based…

Soft Condensed Matter · Physics 2023-04-19 Vishal P. Patil , Ian Ho , Manu Prakash

Regardless of the marked differences between biological and artificial neural systems, one fundamental similarity is that they are essentially dynamical systems that can learn to imitate other dynamical systems, without knowing their…

Neurons and Cognition · Quantitative Biology 2019-11-06 Zhixin Lu , Danielle S. Bassett

Synaptic plasticity allows cortical circuits to learn new tasks and to adapt to changing environments. How do cortical circuits use plasticity to acquire functions such as decision-making or working memory? Neurons are connected in complex…

Neurons and Cognition · Quantitative Biology 2023-03-08 Néstor Parga , Luis Serrano-Fernández , Joan Falcó-Roget

We develop a simple, chemostat-based model illustrating how a process analogous to associative learning can occur in a biochemical network. Associative learning is a form of learning whereby a system "learns" to associate two stimuli with…

Molecular Networks · Quantitative Biology 2007-05-23 Nikhil Ghandi , Gonen Ashkenasy , Emmanuel Tannenbaum

Memristive associative learning has gained significant attention for its ability to mimic fundamental biological learning mechanisms while maintaining system simplicity. In this work, we introduce a high-order memristive associative…

Neural and Evolutionary Computing · Computer Science 2024-10-23 Shengbo Wang , Xuemeng Li , Jialin Ding , Weihao Ma , Ying Wang , Luigi Occhipinti , Arokia Nathan , Shuo Gao

An associative memory is a framework of content-addressable memory that stores a collection of message vectors (or a dataset) over a neural network while enabling a neurally feasible mechanism to recover any message in the dataset from its…

Machine Learning · Statistics 2016-11-30 Arya Mazumdar , Ankit Singh Rawat

Recent progress in diverse intelligence has shown simple learning capacities below the organism level - single cells and even molecular networks. However, there are still many knowledge gaps around learning capacity above the organism…

Populations and Evolution · Quantitative Biology 2026-05-29 Adrita Samanta , Hananel Hazan , Michael Levin

We numerically demonstrate a network of coupled oscillators that can learn to solve a classification task from a set of examples -- performing both training and inference through the nonlinear evolution of the system. We accomplish this by…

Mesoscale and Nanoscale Physics · Physics 2026-01-07 Daan de Bos , Marc Serra-Garcia

Evolution in time-varying environments naturally leads to adaptable biological systems that can easily switch functionalities. Advances in the synthesis of environmentally-responsive materials therefore open up the possibility of creating a…

Living organisms rely on endogenous feedback mechanisms to maintain homeostasis in the presence of uncertainty and environmental fluctuations. An emerging challenge at the interface of control systems engineering and synthetic biology is…

Systems and Control · Electrical Eng. & Systems 2026-02-24 Mario di Bernardo

Recently, it was shown that the amoeba-like cell {\it Physarum polycephalum} when exposed to a pattern of periodic environmental changes learns and adapts its behavior in anticipation of the next stimulus to come. Here we show that such…

Cell Behavior · Quantitative Biology 2009-11-21 Yuriy V. Pershin , Steven La Fontaine , Massimiliano Di Ventra

Animals behave adaptively in the environment with multiply competing goals. Understanding of the mechanisms underlying such goal-directed behavior remains a challenge for neuroscience as well for adaptive system research. To address this…

Neural and Evolutionary Computing · Computer Science 2012-04-17 Konstantin Lakhman , Mikhail Burtsev

Habituation - a phenomenon in which a dynamical system exhibits a diminishing response to repeated stimulations that eventually recovers when the stimulus is withheld - is universally observed in living systems from animals to unicellular…

Adaptation and Self-Organizing Systems · Physics 2024-07-26 Matthew Smart , Stanislav Y. Shvartsman , Martin Mönnigmann
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