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The Luria-Delbr{\"u}ck experiment is a cornerstone of evolutionary theory, demonstrating the randomness of mutations before selection. The distribution of the number of mutants in this experiment has been the subject of intense…

Biological Physics · Physics 2015-07-20 Bahram Houchmandzadeh

Baldwinian and Lamarckian evolution have existed for a long time in evolutionary algorithms (EAs) without ever dominating the academic literature or practical applications. In this work, we use modern empirical and theoretical methods to…

Neural and Evolutionary Computing · Computer Science 2026-05-28 Inès Benito , Johannes F. Lutzeyer , Benjamin Doerr

We discuss the evaluation of Luria-Delbrueck fluctuation experiments under Bellman-Harris models of cell proliferation. It is shown that under certain very natural assumptions concerning the life-time distributions and the offspring…

Probability · Mathematics 2007-05-23 Wolfgang P. Angerer

The classical Luria-Delbr\"uck model for fluctuation analysis is extended to the case where cells can either divide or die at the end of their generation time. This leads to a family of probability distributions generalizing the…

Populations and Evolution · Quantitative Biology 2013-05-30 Bernard Ycart

Originally developed to elucidate the mechanisms of natural selection in bacteria, the Luria-Delbr\"uck model assumed that cells are intrinsically capable of dividing an unlimited number of times. This assumption however, is not true for…

Populations and Evolution · Quantitative Biology 2015-11-17 Ignacio A Rodriguez-Brenes , Dominik Wodarz , Natalia L. Komarova

The Luria--Delbr\"uck mutation model is a cornerstone of evolution theory and has been mathematically formulated in a number of ways. In this paper we illustrate how this model of mutation rates can be derived by means of classical…

Populations and Evolution · Quantitative Biology 2022-12-02 Lorenzo Pareschi , Giuseppe Toscani

This study explores the integration of Lamarckian system into evolutionary robotics (ER), comparing it with the traditional Darwinian model across various environments. By adopting Lamarckian principles, where robots inherit learned traits,…

Robotics · Computer Science 2024-03-29 Jie Luo , Karine Miras , Carlo Longhi , Oliver Weissl , Agoston E. Eiben

Microbial populations adapt to their environment by acquiring advantageous mutations, but in the early twentieth century, questions about how these organisms acquire mutations arose. The experiment of Salvador Luria and Max Delbr\"uck that…

Populations and Evolution · Quantitative Biology 2021-06-24 Stephen Montgomery-Smith , Hesam Oveys

Lamarckian inheritance has been shown to be a powerful accelerator in systems where the joint evolution of robot morphologies and controllers is enhanced with individual learning. Its defining advantage lies in the offspring inheriting…

Robotics · Computer Science 2026-04-20 Jed R Muff , Karine Miras , A. E. Eiben

Instructive influence of environment on heredity has been a debated topic for centuries. Darwin's identification of natural selection coupled to chance variation as the driving force for evolution, against a formal interpretation proposed…

Genomics · Quantitative Biology 2007-05-23 Antoine Danchin

At the fundamental conceptual level, two alternatives have traditionally been considered for how mutations arise and how evolution happens: 1) random mutation and natural selection, and 2) Lamarckism. Recently, the theory of…

Neural and Evolutionary Computing · Computer Science 2026-04-15 Liudmyla Vasylenko , Adi Livnat

Dietrich and Haider (2014) justify their integrative framework for creativity founded on evolutionary theory and prediction research on the grounds that "theories and approaches guiding empirical research on creativity have not been…

Neurons and Cognition · Quantitative Biology 2016-04-15 Liane Gabora , Stuart Kauffman

The Luria-Delbr\"uck distribution is a classical model of mutations in cell kinetics. It is obtained as a limit when the probability of mutation tends to zero and the number of divisions to infinity. It can be interpreted as a compound…

Applications · Statistics 2013-09-11 Agnès Hamon , Bernard Ycart

The Luria-Delbr\"uck mutation model has a long history and has been mathematically formulated in several different ways. Here we tackle the problem in the case of a continuous distribution using some mathematical tools from nonlinear…

Mathematical Physics · Physics 2011-12-14 Eugene Kashdan , Lorenzo Pareschi

In recent years, studies in epigenetic inheritance in biological systems as well as studies on evolution in non-biological systems e.g., machine learning and robotics, have reopened the discussion of non-Darwinian methods of evolutionary…

Adaptation and Self-Organizing Systems · Physics 2023-05-02 Kristoffer Reinholt Thomsen , Steen Rasmussen

Evolutionary robot systems offer two principal advantages: an advanced way of developing robots through evolutionary optimization and a special research platform to conduct what-if experiments regarding questions about evolution. Our study…

Robotics · Computer Science 2023-09-26 Jie Luo , Karine Miras , Jakub Tomczak , Agoston E. Eiben

The Luria-Delbr\"uck model is a classic model of population dynamics with random mutations, that has been used historically to prove that random mutations drive evolution. In typical scenarios, the relevant mutation rate is exceedingly…

Biological Physics · Physics 2024-02-22 Deng Pan , Jie Lin , Ariel Amir

The estimation of mutation probabilities and relative fitnesses in fluctuation analysis is based on the unrealistic hypothesis that the single-cell times to division are exponentially distributed. Using the classical Luria-Delbr\"{u}ck…

Quantitative Methods · Quantitative Biology 2014-03-05 Bernard Ycart

The paper is devoted to the study of Darwinian evolution in two mathematical models. The first one is a variation on the Malthusian population growth model with Verhulst's environmental capacity. The second model is grounded in the theory…

Probability · Mathematics 2025-04-22 Mateusz Krukowski

Current models of animal evolution focus on selection of individuals, ignoring the much faster selection of symbiotic bacteria. Here we take host-symbiont interactions into account by introducing a Population Genetics-like model of…

Populations and Evolution · Quantitative Biology 2016-12-28 Dino Osmanovic , David A Kessler , Yitzhak Rabin , Yoav Soen
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