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The focus of pancreatic cancer research has been shifted from pancreatic cancer cells towards their microenvironment, involving pancreatic stellate cells that interact with cancer cells and influence tumor progression. To quantitatively…

Quantitative Methods · Quantitative Biology 2016-06-13 Qinsi Wang , Natasa Miskov-Zivanov , Bing Liu , James R. Faeder , Michael Lotze , Edmund M. Clarke

Signal transduction networks can form highly interconnected systems within cells due to network crosstalk, the sharing of input signals between multiple downstream responses. To better understand the evolutionary design principles…

Biological Physics · Physics 2018-02-14 Ammar Tareen , Ned S. Wingreen , Ranjan Mukhopadhyay

Deep neural networks are widely known to be susceptible to adversarial examples, which can cause incorrect predictions through subtle input modifications. These adversarial examples tend to be transferable between models, but targeted…

Computer Vision and Pattern Recognition · Computer Science 2023-05-25 Junyoung Byun , Myung-Joon Kwon , Seungju Cho , Yoonji Kim , Changick Kim

Current explanation techniques towards a transparent Convolutional Neural Network (CNN) mainly focuses on building connections between the human-understandable input features with models' prediction, overlooking an alternative…

Machine Learning · Computer Science 2020-05-08 Zifan Wang , Yilin Yang , Ankit Shrivastava , Varun Rawal , Zihao Ding

RNA is a vital biomolecule with numerous roles and functions within cells, and interest in targeting it for therapeutic purposes has grown significantly in recent years. However, fully understanding and predicting RNA behavior, particularly…

Collective cell migration is key during development, wound healing and metastasis and relies on coordinated cell behaviors at the group level. Src kinase is a key signalling protein for physiological functions of epithelia, as it regulates…

Tissues and Organs · Quantitative Biology 2024-10-31 Nastassia Pricoupenko , Flavia Marsigliesi , Philippe Marcq , Carles Blanch-Mercader , Isabelle Bonnet

Cross-protection, which refers to a process whereby artificially inoculating a plant with a mild strain provides protection against a more aggressive isolate of the virus, is known to be an effective tool of disease control in plants. In…

Populations and Evolution · Quantitative Biology 2016-12-07 G. Neofytou , Y. N. Kyrychko , K. B. Blyuss

Spectroscopy infers the internal structure of physical systems by measuring their response to perturbations. We apply this principle to neural networks: perturbing the data distribution by upweighting a token $y$ in context $x$, we measure…

Machine Learning · Computer Science 2026-01-21 Andrew Gordon , Garrett Baker , George Wang , William Snell , Stan van Wingerden , Daniel Murfet

RNA function crucially depends on its structure. Thermodynamic models currently used for secondary structure prediction rely on computing the partition function of folding ensembles, and can thus estimate minimum free-energy structures and…

Biomolecules · Quantitative Biology 2022-07-26 Nicola Calonaci , Alisha Jones , Francesca Cuturello , Michael Sattler , Giovanni Bussi

Competitive interactions represent one of the driving forces behind evolution and natural selection in biological and sociological systems. For example, animals in an ecosystem may vie for food or mates; in a market economy, firms may…

Physics and Society · Physics 2013-07-03 Jacobo Aguirre , David Papo , Javier M. Buldú

Adversarial attack transferability is well-recognized in deep learning. Prior work has partially explained transferability by recognizing common adversarial subspaces and correlations between decision boundaries, but little is known beyond…

Machine Learning · Computer Science 2023-02-24 Christopher Wiedeman , Ge Wang

Neurons in the brain are often finely tuned for specific task variables. Moreover, such disentangled representations are highly sought after in machine learning. Here we mathematically prove that simple biological constraints on neurons,…

Neurons and Cognition · Quantitative Biology 2023-04-04 James C. R. Whittington , Will Dorrell , Surya Ganguli , Timothy E. J. Behrens

We leverage diffusion models to study the robustness-performance tradeoff of robust classifiers. Our approach introduces a simple, pretrained diffusion method to generate low-norm counterfactual examples (CEs): semantically altered data…

Machine Learning · Computer Science 2024-04-18 Eric Yeats , Cameron Darwin , Eduardo Ortega , Frank Liu , Hai Li

The serotonergic system modulates brain processes via functionally distinct subpopulations of neurons with heterogeneous properties, including their electrophysiological activity. In extracellular recordings, serotonergic neurons to be…

Neurons and Cognition · Quantitative Biology 2024-05-10 Daniele Corradetti , Alessandro Bernardi , Renato Corradetti

Genetic oscillators are present in the cells of many organisms and control several biological processes. The common feature of such oscillators is the presence of a protein which represses the transcription of its own gene. Recently, it has…

Molecular Networks · Quantitative Biology 2017-06-07 Nahuel Almeira , Sebastian Risau Gusman

In addition to thermal noise, which is essential to promote conformational transitions in biopolymers, cellular environment is replete with a spectrum of athermal fluctuations that are produced from a plethora of active processes. To…

Biological Physics · Physics 2015-06-11 Won Kyu Kim , Changbong Hyeon , Wokyung Sung

Designing RNA molecules has garnered recent interest in medicine, synthetic biology, biotechnology and bioinformatics since many functional RNA molecules were shown to be involved in regulatory processes for transcription, epigenetics and…

Machine Learning · Computer Science 2019-04-15 Frederic Runge , Danny Stoll , Stefan Falkner , Frank Hutter

Cytoskeletal crowding plays a key role in the diffusion of DNA molecules through the cell, acting as a barrier to effective intracellular transport and conformational stability required for such processes as transfection, viral infection,…

Contrastive learning has proven to be an effective method for pre-training models using weakly labeled data in the vision domain. Sentence transformers are the NLP counterparts to this architecture, and have been growing in popularity due…

Computation and Language · Computer Science 2023-11-30 Tanmay Chavan , Shantanu Patankar , Aditya Kane , Omkar Gokhale , Geetanjali Kale , Raviraj Joshi

The paper considers the problem of multi-agent consensus in the presence of adversarial agents which may try to prevent and introduce undesired influence on the coordination among the regular agents. To our setting, we extend the so-called…

Systems and Control · Electrical Eng. & Systems 2020-12-25 Hiroki Matsume , Yuan Wang , Hideaki Ishii