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Joint models for longitudinal and time-to-event data are widely used in many disciplines. Nonetheless, existing model comparison criteria do not indicate whether a model adequately fits the data or which components may be misspecified. We…

Methodology · Statistics 2026-01-27 Dimitris Rizopoulos , Jeremy M. G. Taylor , Isabella Kardys

Health policy decisions are often informed by estimates of long-term survival based primarily on short-term data. A range of methods are available to include longer-term information, but there has previously been no comprehensive and…

Methodology · Statistics 2025-05-05 Christopher Jackson

Composite endpoints that combine recurrent non-fatal events with a terminal event are increasingly used in randomized clinical trials, yet conventional time-to-first event analyses may obscure clinically relevant information. We compared…

Methodology · Statistics 2025-12-16 Adrien Orué , Derek Dinart , Laurent Billot , Carine Bellera , Virginie Rondeau

Often in Phase 3 clinical trials measuring a long-term time-to-event endpoint, such as overall survival or progression-free survival, investigators also collect repeated measures on biomarkers which may be predictive of the primary…

Methodology · Statistics 2022-11-30 Abigail J. Burdon , Lisa V. Hampson , Christopher Jennison

Dependent survival data arise in many contexts. One context is clustered survival data, where survival data are collected on clusters such as families or medical centers. Dependent survival data also arise when multiple survival times are…

Methodology · Statistics 2022-05-12 Malka Gorfine , David M. Zucker

Recurrent event analyses have found a wide range of applications in biomedicine, public health, and engineering, among others, where study subjects may experience a sequence of event of interest during follow-up. The R package reReg (Chiou…

Computation · Statistics 2022-08-23 Sy Han Chiou , Gongjun Xu , Jun Yan , Chiung-Yu Huang

Increasing evidence suggests that variability in longitudinal biomarkers, in addition to their mean trajectory, carries prognostic information for time-to-event outcomes. However, standard joint models typically capture only the expected…

Methodology · Statistics 2026-05-08 Felix Boakye Oppong , Dimitris Rizopoulos , Thierry Gorlia , Nicole Erler

This paper introduces the R package INLAjoint, designed as a toolbox for fitting a diverse range of regression models addressing both longitudinal and survival outcomes. INLAjoint relies on the computational efficiency of the integrated…

Methodology · Statistics 2024-04-04 Denis Rustand , Janet van Niekerk , Elias Teixeira Krainski , Håvard Rue

Joint models of longitudinal and event-time data have been extensively studied and applied in many different fields. Estimation of joint models is challenging, most present procedures are computational expensive and have a strict…

Methodology · Statistics 2018-09-05 Yanqiao Zheng , Xiaobing Zhao , Xiaoqi Zhang

Observational studies are often conducted to estimate causal effects of treatments or exposures on event-time outcomes. Since treatments are not randomized in observational studies, techniques from causal inference are required to adjust…

Methodology · Statistics 2023-10-23 Han Ji , Arman Oganisian

Analyzing time-series cross-sectional (also known as longitudinal or panel) data is an important process across a number of fields, including the social sciences, economics, finance, and medicine. PanelMatch is an R package that implements…

Methodology · Statistics 2025-08-19 Adam Rauh , In Song Kim , Kosuke Imai

The statistical analysis of structured spatial point process data where the event locations are determined by an underlying spatially embedded relational system has become a vivid field of research. Despite a growing literature on different…

Methodology · Statistics 2022-12-13 Pol Llagostera , Carles Comas , Matthias Eckardt

Modeling longitudinal and survival data jointly offers many advantages such as addressing measurement error and missing data in the longitudinal processes, understanding and quantifying the association between the longitudinal markers and…

Joint modeling has become increasingly popular for characterizing the association between one or more longitudinal biomarkers and competing risks time-to-event outcomes. However, semiparametric multivariate joint modeling for large-scale…

Methodology · Statistics 2025-06-17 Shanpeng Li , Emily Ouyang , Jin Zhou , Xinping Cui , Gang Li

The joint modeling of longitudinal and time-to-event data is an active area of statistics research that has received a lot of attention in the recent years. More recently, a new and attractive application of this type of models has been to…

This article explains the usage of R package CausalModels, which is publicly available on the Comprehensive R Archive Network. While packages are available for sufficiently estimating causal effects, there lacks a package that provides a…

Methodology · Statistics 2023-07-19 Joshua Wolff Anderson , Cyril Rakovski

In recurrent survival analysis where the event of interest can occur multiple times for each subject, frailty models play a crucial role by capturing unobserved heterogeneity at the subject level within a population. Frailty models…

Methodology · Statistics 2024-10-30 Borna Bateni , Peyman Bateni , Bishwadeep Bhattacharyya , Devin Reeh

Understanding the temporal properties of longitudinal data is critical for identifying trends, predicting future events, and making informed decisions in any field where temporal data is analysed, including health and epidemiology, finance,…

This contribution presents a guide to the R package multilevLCA, which offers a complete and innovative set of technical tools for the latent class analysis of single-level and multilevel categorical data. We describe the available model…

Computation · Statistics 2024-04-11 Johan Lyrvall , Roberto Di Mari , Zsuzsa Bakk , Jennifer Oser , Jouni Kuha

Many important social phenomena are characterized by repeated interactions among individuals over time such as email exchanges in an organization or face-to-face interactions in a classroom. To understand the underlying mechanisms of social…

Social and Information Networks · Computer Science 2025-01-09 Rumana Lakdawala , Joris Mulder , Roger Leenders