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High-resolution blood flow simulations have potential for developing better understanding biophysical phenomena at the microscale, such as vasodilation, vasoconstriction and overall vascular resistance. To this end, we present a scalable…

Computational Engineering, Finance, and Science · Computer Science 2019-09-26 Libin Lu , Matthew J. Morse , Abtin Rahimian , Georg Stadler , Denis Zorin

We present a rigorous procedure to derive coarse-grained red blood cell (RBC) models, which lead to accurate mechanical properties of realistic RBCs. Based on a semi-analytic theory linear and non-linear elastic properties of the RBC…

Cell Behavior · Quantitative Biology 2009-05-04 Dmitry A. Fedosov , Bruce Caswell , George E. Karniadakis

Computational modeling and simulation are presented on the motion of red blood cells behind a moving interface in a capillary. The methodology is based on an immersed boundary method and the skeleton structure of the red blood cell (RBC)…

Fluid Dynamics · Physics 2013-04-16 Shihai Zhao , Tsorng-Whay Pan

We present a computational framework for the simulation of blood flow with fully resolved red blood cells (RBCs) using a modular approach that consists of a lattice Boltzmann solver for the blood plasma, a novel finite element based solver…

Computational Physics · Physics 2019-08-28 Christos Kotsalos , Jonas Latt , Bastien Chopard

In this work, we review previously developed coarse-grained (CG) particle models for biological membrane and red blood cells (RBCs) and discuss the advantages of the CG particle method over the continuum and atomic simulations on modeling…

Soft Condensed Matter · Physics 2017-07-18 He Li , Hung-yu Chang , Jun Yang , Lu Lu , George Lykotrafitis

We investigate the dynamics of the Red Blood Cell (RBC) in microfluidic channels under oscillatory flows. The simulations employ a hybrid continuum-particle approach, in which the cell membrane and cytosol fluid are modeled using…

Fluid Dynamics · Physics 2023-07-18 Lahcen Akerkouch , Trung Bao Le

Colorectal cancer screening critically depends on colonoscopy, yet existing platforms offer limited support for systematically studying the coupled dynamics of operator control, instrument motion, and visual feedback. This gap restricts…

Red blood cells (RBCs) are an essential component of blood. A method to include the particulate nature of blood is introduced here with the goal of studying circulation in large-scale realistic vessels. The method uses a combination of the…

Medical Physics · Physics 2011-07-26 Simone Melchionna

The flow dynamics of red blood cells in vivo in blood capillaries and in vitro in microfluidic channels is complex. Cells can obtain differnet shapes such as discoid, parachute, slipper-like shapes and various intermediate states depending…

Biological Physics · Physics 2023-04-17 Andreas Link , a Irene Luna Pardo , Bernd Porr , Thomas Franke

Microcapsules with liquid cores encapsulated by thin membranes have many applications in science, medicine and industry. In this paper, we design a suspension of microcapsules which flow and deform like red blood cells (RBCs), as a valuable…

Soft Condensed Matter · Physics 2023-02-22 Qi Chen , Naval Singh , Kerstin Schirrmann , Qi Zhou , Igor Chernyavsky , Anne Juel

Stochastic partition models divide a multi-dimensional space into a number of rectangular regions, such that the data within each region exhibit certain types of homogeneity. Due to the nature of their partition strategy, existing partition…

Machine Learning · Statistics 2019-03-12 Xuhui Fan , Bin Li , Scott Anthony Sisson

Mesoscopic numerical simulations provide a unique approach for the quantification of the chemical influences on red blood cell functionalities. The transport Dissipative Particles Dynamics (tDPD) method can lead to such effective multiscale…

Computational Physics · Physics 2017-06-07 Ansel L. Blumers , Yu-Hang Tang , Zhen Li , Xuejin Li , George E. Karniadakis

In many scientific domains, researchers are turning to large-scale behavioral simulations to better understand important real-world phenomena. While there has been a great deal of work on simulation tools from the high-performance computing…

For plane-wave and many-spiral states of the experimentally based Luo-Rudy 1 model of heart tissue in large (8 cm square) domains, we show that an explicit space-time-adaptive time-integration algorithm can achieve an order of magnitude…

Computational Physics · Physics 2009-10-31 Elizabeth M. Cherry , Henry S. Greenside , Craig S. Henriquez

Red Blood Cells (RBCs) are the simplest cell types with complex dynamical and viscoelastic phenomenology. While the mechanical rigidity and the flickering noise of RBCs have been extensively investigated, an accurate determination of the…

Biological Physics · Physics 2023-08-25 M. Gironella-Torrent , G. Bergamaschi , R. Sorkin , G. Wuite , F. Ritort

This paper introduces a random-batch molecular dynamics (RBMD) package for fast simulations of particle systems at the nano/micro scale. Different from existing packages, the RBMD uses random batch methods for nonbonded interactions of…

Computational Physics · Physics 2025-11-11 Weihang Gao , Teng Zhao , Yongfa Guo , Jiuyang Liang , Huan Liu , Maoying Luo , Zedong Luo , Wei Qin , Yichao Wang , Qi Zhou , Shi Jin , Zhenli Xu

The fluid dynamics video presented here outlines recent advances in the simulation of multiphase cellular blood flow through the direct numerical simulations of deformable red blood cells (RBCs) demonstrated through several numerical…

Fluid Dynamics · Physics 2010-10-18 Daniel A. Reasor , Jonathan R. Clausen , Brian M. Yun , Cyrus K. Aidun

Furthering our understanding of many of today's interesting problems in plasma physics---including plasma based acceleration and magnetic reconnection with pair production due to quantum electrodynamic effects---requires large-scale kinetic…

Computational Physics · Physics 2020-10-28 Kyle G. Miller , Roman P. Lee , Adam Tableman , Anton Helm , Ricardo A. Fonseca , Viktor K. Decyk , Warren B. Mori

Computational Fluid Dynamics (CFD) is currently used to design and improve the hydraulic properties of biomedical devices, wherein the large scale blood circulation needs to be simulated by accounting for the mechanical response of red…

Fluid Dynamics · Physics 2024-12-24 F. Guglietta , M. Behr , L. Biferale , G. Falcucci , M. Sbragaglia

Identification of abnormalities in red blood cells (RBC) is key to diagnosing a range of medical conditions from anaemia to liver disease. Currently this is done manually, a time-consuming and subjective process. This paper presents an…

Computer Vision and Pattern Recognition · Computer Science 2021-06-02 Annika Wong , Nantheera Anantrasirichai , Thanarat H. Chalidabhongse , Duangdao Palasuwan , Attakorn Palasuwan , David Bull
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