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Our sense of smell relies on sensitive, selective atomic-scale processes that are initiated when a scent molecule meets specific receptors in the nose. However, the physical mechanisms of detection are not clear. While odorant shape and…

Biological Physics · Physics 2015-06-26 Jennifer C. Brookes , Filio Hartoutsiou , A. P. Horsfield , A. M. Stoneham

The mechanism by which odorants are recognized by olfactory receptors remains primarily unresolved. While charge transport is believed to play a significant role, its precise nature is still unclear. Here, we present a novel perspective by…

Chemical Physics · Physics 2025-06-30 Dominik Szczȩśniak , Ewa Drzazga-Szczȩśniak , Sabre Kais

The vibrational theory of olfaction was posited to explain subtle effects in the sense of smell inexplicable by models in which molecular structure alone determines an odorant's smell. Amazingly, behavioral and neurophysiological evidence…

Biological Physics · Physics 2019-05-01 Nishattasnim Liza , Enrique P. Blair

Inelastic electron transfer being regarded as one of the potential mechanisms to explain the odorant recognition in the atomic-scale processes is still a matter of intense debate. Here, we propose multiphonon processes of electrons transfer…

Biological Physics · Physics 2021-08-02 Shu-Quan Zhang , Yu Cui , Xue-Wei Li , Yong Sun , Zi-Wu Wang

Motivated by a proposed olfactory mechanism based on a vibrationally-activated molecular switch, we study electron transport within a donor-acceptor pair that is coupled to a vibrational mode and embedded in a surrounding environment. We…

Mesoscale and Nanoscale Physics · Physics 2015-02-12 Agata Checinska , Felix A. Pollock , Libby Heaney , Ahsan Nazir

The standard model for molecular recognition of an odorant is that receptor sites discriminate by molecular geometry as evidenced that two chiral molecules may smell very differently. However, recent studies of isotopically labeled…

Biological Physics · Physics 2015-06-05 Eric R. Bittner , Adrian Madalan , Arkadiuz Czader , Gregg Roman

Odor-based Molecular Communication (OMC) employs odor molecules to convey information, contributing to the realization of the Internet of Everything (IoE) vision. Despite this, the practical deployment of OMC systems is currently limited by…

Signal Processing · Electrical Eng. & Systems 2026-02-03 Ahmet B. Kilic , Fatih E. Bilgen , Ozgur B. Akan

The sense of smell is an important part of living organisms. It assists with the interaction of the living organism with its environment. The mechanism by which smell is detected and identified is not fully known. Earlier, shape theory was…

Biological Physics · Physics 2019-11-07 Chukwuemeka Asogwa

We introduce and study an artificial neural network, inspired by the probabilistic Receptor Affinity Distribution model of olfaction. Our system consists on N sensory neurons whose outputs converge on a single processing linear threshold…

Disordered Systems and Neural Networks · Physics 2007-05-23 N. Caticha , J. E. Palo Tejada , D. Lancet , E. Domany

In this work we consider the question of whether a simple diffusive model can explain the scent tracking behaviours found in nature. For this behaviour to occur, both the concentration of a scent and its gradient must be above some…

Soft Condensed Matter · Physics 2021-03-31 Gerard McCaul , Andreas Mershin , Denys I. Bondar

Odor detection underpins food safety, environmental monitoring, medical diagnostics, and many more fields. The current artificial sensors developed for odor detection struggle with complex mixtures while non-invasive recordings lack…

Machine Learning · Computer Science 2025-08-14 Matin Hassanloo , Ali Zareh , Mehmet Kemal Özdemir

Neuromorphic computing is one of the few current approaches that have the potential to significantly reduce power consumption in Machine Learning and Artificial Intelligence. Imam & Cleland presented an odour-learning algorithm that runs on…

Neural and Evolutionary Computing · Computer Science 2023-09-22 Nik Dennler , André van Schaik , Michael Schmuker

We present a model of a coupled system of the olfactory bulb and cortex. Odor inputs to the epithelium are transformed to oscillatory bulbar activities. The cortex recognizes the odor by resonating to the bulbar oscillating pattern when the…

Biological Physics · Physics 2007-05-23 Zhaoping Li , John Hertz

Olfactory systems use a small number of broadly sensitive receptors to combinatorially encode a vast number of odors. We propose a method of decoding such distributed representations by exploiting a statistical fact: receptors that do not…

Neurons and Cognition · Quantitative Biology 2021-09-01 Vijay Singh , Martin Tchernookov , Vijay Balasubramanian

We present a model of an olfactory system that performs odor segmentation. Based on the anatomy and physiology of natural olfactory systems, it consists of a pair of coupled modules, bulb and cortex. The bulb encodes the odor inputs as…

Disordered Systems and Neural Networks · Physics 2007-05-23 Zhaoping Li , John Hertz

Predicting olfactory perception directly from molecular structure is central to fragrance design that plays a role in a wide range of industries, such as perfumery, food and beverage, and health care. Among olfactory attributes, odor…

Chemical Physics · Physics 2026-05-18 Peter Fichtelmann , Julia Westermayr

We present a generalized theoretical framework for olfactory representation and plasticity, using the theory of smooth manifolds and sheaves to depict categorical odor learning via distributed neural computation. Beginning with the space of…

Neurons and Cognition · Quantitative Biology 2023-10-13 Jack A. Cook , Thomas A. Cleland

We present a model of dissipative transport in the fractional quantum Hall regime. Our model takes account of tunneling through saddle points in the effective potential for excitations created by impurities. We predict the temperature range…

Mesoscale and Nanoscale Physics · Physics 2011-03-28 N. d'Ambrumenil , B. I. Halperin , R. H. Morf

The olfactory system is constantly solving pattern-recognition problems by the creation of a large space to codify odour representations and optimizing their distribution within it. A model of the Olfactory Bulb was developed by Z. Li and…

Adaptation and Self-Organizing Systems · Physics 2019-05-16 Alexandra Pinto

Understanding how molecular structure gives rise to odor perception remains a long-standing challenge, with ongoing debate over whether olfaction is primarily governed by molecular shape, vibrational properties, or their interplay at the…

Materials Science · Physics 2026-04-14 P. Zanineli , E. V. C. Lopes , G. R. Schleder , L. N. Lemos , F. Crasto de Lima , A. Fazzio
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