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Histopathology whole slide images (WSIs) play a very important role in clinical studies and serve as the gold standard for many cancer diagnoses. However, generating automatic tools for processing WSIs is challenging due to their enormous…

Computer Vision and Pattern Recognition · Computer Science 2022-09-28 Jingwei Zhang , Xin Zhang , Ke Ma , Rajarsi Gupta , Joel Saltz , Maria Vakalopoulou , Dimitris Samaras

Weakly supervised object detection (WSOD) is a challenging task when provided with image category supervision but required to simultaneously learn object locations and object detectors. Many WSOD approaches adopt multiple instance learning…

Computer Vision and Pattern Recognition · Computer Science 2019-04-12 Fang Wan , Chang Liu , Wei Ke , Xiangyang Ji , Jianbin Jiao , Qixiang Ye

Histopathological image segmentation is a challenging and important topic in medical imaging with tremendous potential impact in clinical practice. State of the art methods rely on hand-crafted annotations which hinder clinical translation…

Various multi-instance learning (MIL) based approaches have been developed and successfully applied to whole-slide pathological images (WSI). Existing MIL methods emphasize the importance of feature aggregators, but largely neglect the…

Computer Vision and Pattern Recognition · Computer Science 2025-05-13 Yicheng Song , Tiancheng Lin , Die Peng , Su Yang , Yi Xu

We propose a Deep learning-based weak label learning method for analyzing whole slide images (WSIs) of Hematoxylin and Eosin (H&E) stained tumor tissue not requiring pixel-level or tile-level annotations using Self-supervised pre-training…

Image and Video Processing · Electrical Eng. & Systems 2023-06-29 Yoni Schirris , Efstratios Gavves , Iris Nederlof , Hugo Mark Horlings , Jonas Teuwen

Nuclei instance segmentation on histopathology images is of great clinical value for disease analysis. Generally, fully-supervised algorithms for this task require pixel-wise manual annotations, which is especially time-consuming and…

Computer Vision and Pattern Recognition · Computer Science 2023-06-06 Yang Zhou , Yongjian Wu , Zihua Wang , Bingzheng Wei , Maode Lai , Jianzhong Shou , Yubo Fan , Yan Xu

Nodule segmentation from breast ultrasound images is challenging yet essential for the diagnosis. Weakly-supervised segmentation (WSS) can help reduce time-consuming and cumbersome manual annotation. Unlike existing weakly-supervised…

Computer Vision and Pattern Recognition · Computer Science 2021-08-03 Yuhao Huang , Xin Yang , Yuxin Zou , Chaoyu Chen , Jian Wang , Haoran Dou , Nishant Ravikumar , Alejandro F Frangi , Jianqiao Zhou , Dong Ni

This paper presents a novel unsupervised segmentation method for 3D medical images. Convolutional neural networks (CNNs) have brought significant advances in image segmentation. However, most of the recent methods rely on supervised…

Computer Vision and Pattern Recognition · Computer Science 2018-04-13 Takayasu Moriya , Holger R. Roth , Shota Nakamura , Hirohisa Oda , Kai Nagara , Masahiro Oda , Kensaku Mori

Due to its superior efficiency in utilizing annotations and addressing gigapixel-sized images, multiple instance learning (MIL) has shown great promise as a framework for whole slide image (WSI) classification in digital pathology…

Quantitative Methods · Quantitative Biology 2023-07-14 Qiehe Sun , Jiawen Li , Jin Xu , Junru Cheng , Tian Guan , Yonghong He

Weakly-supervised learning (WSL) has recently triggered substantial interest as it mitigates the lack of pixel-wise annotations. Given global image labels, WSL methods yield pixel-level predictions (segmentations), which enable to interpret…

Computer Vision and Pattern Recognition · Computer Science 2021-10-12 Soufiane Belharbi , Jérôme Rony , Jose Dolz , Ismail Ben Ayed , Luke McCaffrey , Eric Granger

The recent state-of-the-art deep learning methods have significantly improved brain tumor segmentation. However, fully supervised training requires a large amount of manually labeled masks, which is highly time-consuming and needs domain…

Image and Video Processing · Electrical Eng. & Systems 2019-11-07 Zhanghexuan Ji , Yan Shen , Chunwei Ma , Mingchen Gao

Image segmentation is a fundamental and challenging problem in computer vision with applications spanning multiple areas, such as medical imaging, remote sensing, and autonomous vehicles. Recently, convolutional neural networks (CNNs) have…

Computer Vision and Pattern Recognition · Computer Science 2020-06-24 Ali Hatamizadeh

Lesion segmentation on computed tomography (CT) scans is an important step for precisely monitoring changes in lesion/tumor growth. This task, however, is very challenging since manual segmentation is prohibitively time-consuming,…

Computer Vision and Pattern Recognition · Computer Science 2020-01-24 Vatsal Agarwal , Youbao Tang , Jing Xiao , Ronald M. Summers

Background and objective: Employing deep learning models in critical domains such as medical imaging poses challenges associated with the limited availability of training data. We present a strategy for improving the performance and…

Computer Vision and Pattern Recognition · Computer Science 2024-03-27 Eva Pachetti , Sotirios A. Tsaftaris , Sara Colantonio

Prostate cancer is the most common cancer in men worldwide and the second leading cause of cancer death in the United States. One of the prognostic features in prostate cancer is the Gleason grading of histopathology images. The Gleason…

Image and Video Processing · Electrical Eng. & Systems 2022-12-27 Mohammad Mahdi Behzadi , Mohammad Madani , Hanzhang Wang , Jun Bai , Ankit Bhardwaj , Anna Tarakanova , Harold Yamase , Ga Hie Nam , Sheida Nabavi

Deep learning for medical image classification faces three major challenges: 1) the number of annotated medical images for training are usually small; 2) regions of interest (ROIs) are relatively small with unclear boundaries in the whole…

Computer Vision and Pattern Recognition · Computer Science 2019-10-23 Shaohua Li , Yong Liu , Xiuchao Sui , Cheng Chen , Gabriel Tjio , Daniel Shu Wei Ting , Rick Siow Mong Goh

We present a pioneering investigation into the application of deep learning techniques to analyze histopathological images for addressing the substantial challenge of automated prognostic prediction. Prognostic prediction poses a unique…

The burgeoning discipline of computational pathology shows promise in harnessing whole slide images (WSIs) to quantify morphological heterogeneity and develop objective prognostic modes for human cancers. However, progress is impeded by the…

Computer Vision and Pattern Recognition · Computer Science 2025-10-20 Chao Tu , Kun Huang , Jie Zhang , Qianjin Feng , Yu Zhang , Zhenyuan Ning

Despite deep convolutional neural networks boost the performance of image classification and segmentation in digital pathology analysis, they are usually weak in interpretability for clinical applications or require heavy annotations to…

Computer Vision and Pattern Recognition · Computer Science 2020-02-10 Yongxiang Huang , Albert C. S. Chung

Image segmentation is a fundamental task in the field of imaging and vision. Supervised deep learning for segmentation has achieved unparalleled success when sufficient training data with annotated labels are available. However, annotation…

Image and Video Processing · Electrical Eng. & Systems 2023-04-10 Hongrun Zhang , Liam Burrows , Yanda Meng , Declan Sculthorpe , Abhik Mukherjee , Sarah E Coupland , Ke Chen , Yalin Zheng