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Models of tumor growth, now commonly used, present several levels of complexity, both in terms of the biomedical ingredients and the mathematical description. The simplest ones contain competition for space using purely fluid mechanical…

Analysis of PDEs · Mathematics 2015-06-12 Benoît Perthame , Fernando Quirós , Juan Luis Vázquez

We formulate a Hele-Shaw type free boundary problem for a tumor growing under the combined effects of pressure forces, cell multiplication and active motion, the latter being the novelty of the present paper. This new ingredient is…

Analysis of PDEs · Mathematics 2014-01-14 Benoît Perthame , Fernando Quirós , Min Tang , Nicolas Vauchelet

We consider weak solutions to a problem modeling tumor growth. Under certain conditions on the initial data, solutions can be obtained by passing to the stiff (incompressible) limit in a porous medium type problem with a Lotka-Volterra…

Analysis of PDEs · Mathematics 2015-12-23 Antoine Mellet , Benoît Perthame , Fernando Quiros

In this paper, we study the tumor growth equation along with various models for the nutrient component, including the \emph{in vitro} model and the \emph{in vivo} model. At the cell density level, the spatial availability of the tumor…

Analysis of PDEs · Mathematics 2018-02-05 Jian-Guo Liu , Min Tang , Li Wang , Zhennan Zhou

We consider the problem of the long time dynamics for a diffuse interface model for tumor growth. The model describes the growth of a tumor surrounded by host tissues in the presence of a nutrient and consists in a Cahn-Hilliard-type…

Analysis of PDEs · Mathematics 2018-10-30 Alain Miranville , Elisabetta Rocca , Giulio Schimperna

Multiphase mechanical models are now commonly used to describe living tissues including tumour growth. The specific model we study here consists of two equations of mixed parabolic and hyperbolic type which extend the standard compressible…

Analysis of PDEs · Mathematics 2020-01-08 Federica Bubba , Benoît Perthame , Camille Pouchol , Markus Schmidtchen

Several mathematical models of tumor growth are now commonly used to explain medical observations and predict cancer evolution based on images. These models incorporate mechanical laws for tissue compression combined with rules for…

Analysis of PDEs · Mathematics 2014-01-16 Benoît Perthame , Min Tang , Nicolas Vauchelet

A mathematical model for tissue growth is considered. This model describes the dynamics of the density of cells due to pressure forces and proliferation. It is known that such cell population model converges at the incompressible limit…

Analysis of PDEs · Mathematics 2017-03-01 Sophie Hecht , Nicolas Vauchelet

This paper proposes a model for the growth two interacting populations of cells that do not mix. The dynamics is driven by pressure and cohesion forces on the one hand and proliferation on the other hand. Following earlier works on the…

Cell Behavior · Quantitative Biology 2018-04-12 Alina Chertock , Pierre Degond , Sophie Hecht , Jean-Paul Vincent

We consider a Hele-Shaw model that describes tumor growth subject to nutrient supply. The model is derived by taking the incompressible limit of porous medium type equations, and the boundary instability of this model was recently studied…

Analysis of PDEs · Mathematics 2025-05-13 Yu Feng , Qingyou He , Jian-Guo Liu , Zhennan Zhou

We investigate the long-time dynamics and optimal control problem of a diffuse interface model that describes the growth of a tumor in presence of a nutrient and surrounded by host tissues. The state system consists of a Cahn-Hilliard type…

Analysis of PDEs · Mathematics 2023-07-28 Cecilia Cavaterra , Elisabetta Rocca , Hao Wu

We study the incompressible limit of the porous medium equation with a right hand side representing either a source or a sink term, and an injection boundary condition. This model can be seen as a simplified description of non-monotone…

Analysis of PDEs · Mathematics 2022-01-12 Nestor Guillen , Inwon Kim , Antoine Mellet

Various models of tumor growth are available in the litterature. A first class describes the evolution of the cell number density when considered as a continuous visco-elastic material with growth. A second class, describes the tumor as a…

Analysis of PDEs · Mathematics 2016-02-17 Benoit Perthame , Nicolas Vauchelet

This paper investigates the incompressible limit of a system modelling the growth of two cells population. The model describes the dynamics of cell densities, driven by pressure exclusion and cell proliferation. It has been shown that…

Analysis of PDEs · Mathematics 2019-01-08 P. Degond , S. Hecht , N. Vauchelet

In this work, we discuss a cell-cell repulsion population dynamic model based on a hyperbolic Keller-Segel equation with two populations. This model can well describe the cell growth and dispersion in the cell co-culture experiment in the…

Analysis of PDEs · Mathematics 2019-07-26 Xiaoming Fu , Quentin Griette , Pierre Magal

In this paper, we consider an age-structured mechanical model for tumor growth. This model takes into account the life-cycle of tumor cells by including an age variable. The underlying process for tumor growth is the same as classical tumor…

Analysis of PDEs · Mathematics 2026-03-05 Maeve Wildes

In this paper we study the "stiff pressure limit" of the porous medium equation, where the initial density is a bounded, integrable function with a sufficient decay at infinity. Our particular model, introduced by Perthame-Quiros-Vazquez,…

Analysis of PDEs · Mathematics 2015-09-22 Inwon Kim , Norbert Pozar

We discuss several continuum cell-cell adhesion models based on the underlying microscopic assumptions. We propose an improvement on these models leading to sharp fronts and intermingling invasion fronts between different cell type…

Cell Behavior · Quantitative Biology 2019-01-11 Jose A. Carrillo , Hideki Murakawa , Makoto Sato , Hideru Togashi , Olena Trush

It has been shown experimentally that contact interactions may influence the migration of cancer cells. Previous works have modelized this thanks to stochastic, discrete models (cellular automata) at the cell level. However, for the study…

Cell Behavior · Quantitative Biology 2009-03-26 Christophe Deroulers , Marine Aubert , Mathilde Badoual , Basil Grammaticos

In this study, we analyze the behavior of monotone traveling waves of a one-dimensional porous medium equation modeling mechanical properties of living tissues. We are interested in the asymptotics where the pressure, which governs the…

Analysis of PDEs · Mathematics 2021-08-25 Anne-Laure Dalibard , Gabriela Lopez-Ruiz , Charlotte Perrin
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