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Microarray techniques are widely used in Gene expression analysis. These techniques are based on discovering submatrices of genes that share similar expression patterns across a set of experimental conditions with coherence constraint.…

Quantitative Methods · Quantitative Biology 2020-01-27 Bilal Taher , Muhammad. H Fares , Saeed Jalili

Microarray technology is known as one of the most important tools for collecting DNA expression data. This technology allows researchers to investigate and examine types of diseases and their origins. However, microarray data are often…

Quantitative Methods · Quantitative Biology 2021-01-05 Babak Nouri-Moghaddam , Mehdi Ghazanfari , Mohammad Fathian

Microarray data analysis is one of the major area of research in the field computational biology. Numerous techniques like clustering, biclustering are often applied to microarray data to extract meaningful outcomes which play key roles in…

Neural and Evolutionary Computing · Computer Science 2019-09-04 Shubhankar Mohapatra , Moumita Sarkar , Anjali Mohapatra , Bhawani Sankar Biswal

Transcriptional profiling on microarrays to obtain gene expressions has been used to facilitate cancer diagnosis. We propose a deep generative machine learning architecture (called DeepCancer) that learn features from unlabeled microarray…

Artificial Intelligence · Computer Science 2016-12-14 Rajendra Rana Bhat , Vivek Viswanath , Xiaolin Li

In statistics and machine learning, feature selection is the process of picking a subset of relevant attributes for utilizing in a predictive model. Recently, rough set-based feature selection techniques, that employ feature dependency to…

Machine Learning · Computer Science 2020-03-30 Seyedeh Faezeh Farahbakhshian , Milad Taleby Ahvanooey

Microarray gene expression data are often accompanied by a large number of genes and a small number of samples. However, only a few of these genes are relevant to cancer, resulting in signigicant gene selection challenges. Hence, we propose…

Machine Learning · Computer Science 2021-06-11 Xiongshi Deng , Min Li , Shaobo Deng , Lei Wang

Gene expression data represents a unique challenge in predictive model building, because of the small number of samples $(n)$ compared to the huge amount of features $(p)$. This "$n<<p$" property has hampered application of deep learning…

Machine Learning · Statistics 2018-02-13 Yunchuan Kong , Tianwei Yu

We present a novel coupled two-way clustering approach to gene microarray data analysis. The main idea is to identify subsets of the genes and samples, such that when one of these is used to cluster the other, stable and significant…

Biological Physics · Physics 2009-11-06 G. Getz , E. Levine , E. Domany

We compare in this paper several feature selection methods for the Naive Bayes Classifier (NBC) when the data under study are described by a large number of redundant binary indicators. Wrapper approaches guided by the NBC estimation of the…

Machine Learning · Statistics 2015-06-16 Tsirizo Rabenoro , Jérôme Lacaille , Marie Cottrell , Fabrice Rossi

This paper proposes a novel Extended Particle Swarm Optimization model (EPSO) that potentially enhances the search process of PSO for optimization problem. Evidently, gene expression profiles are significantly important measurement factor…

Neural and Evolutionary Computing · Computer Science 2020-08-11 Ali Hakem Alsaeedi , Adil L. Albukhnefis , Dhiah Al-Shammary , Muntasir Al-Asfoor

For many classification and regression problems, a large number of features are available for possible use - this is typical of DNA microarray data on gene expression, for example. Often, for computational or other reasons, only a small…

Statistics Theory · Mathematics 2007-06-13 Longhai Li , Jianguo Zhang , Radford M. Neal

In this work a new way to calculate the multivariate joint entropy is presented. This measure is the basis for a fast information-theoretic based evaluation of gene relevance in a Microarray Gene Expression data context. Its low complexity…

Quantitative Methods · Quantitative Biology 2013-02-08 Fernando González , Lluís A. Belanche

Feature selection is a crucial step in developing robust and powerful machine learning models. Feature selection techniques can be divided into two categories: filter and wrapper methods. While wrapper methods commonly result in strong…

Machine Learning · Computer Science 2022-07-07 Jarne Verhaeghe , Jeroen Van Der Donckt , Femke Ongenae , Sofie Van Hoecke

miRNA and gene expression profiles have been proved useful for classifying cancer samples. Efficient classifiers have been recently sought and developed. A number of attempts to classify cancer samples using miRNA/gene expression profiles…

Computational Engineering, Finance, and Science · Computer Science 2014-01-21 Rania Ibrahim , Noha A. Yousri , Mohamed A. Ismail , Nagwa M. El-Makky

Introduction The focus of analyzing data from microarray experiments and extracting biological insight from such data has experienced a shift from identification of individual genes in association with a phenotype to that of biological…

Genomics · Quantitative Biology 2015-08-10 Lei Zhang , Linlin Wang , Pu Tian , Suyan Tian

In computational biology, gene expression datasets are characterized by very few individual samples compared to a large number of measurements per sample. Thus, it is appealing to merge these datasets in order to increase the number of…

Methodology · Statistics 2011-08-18 Meili Baragatti

One of the notable fields in studying the genetics of cancer is disease gene identification which affects disease treatment and drug discovery. Many researches have been done in this field. Genome-wide association studies (GWAS) are one of…

Computational Engineering, Finance, and Science · Computer Science 2016-04-27 Zahra Razaghi-Moghadama , Razieh Abdollahia , Sama Goliaeib , Morteza Ebrahimia

In today's data driven world, storing, processing, and gleaning insights from large-scale data are major challenges. Data compression is often required in order to store large amounts of high-dimensional data, and thus, efficient inference…

Machine Learning · Statistics 2018-09-11 Denali Molitor , Deanna Needell

The majority of machine learning methods and algorithms give high priority to prediction performance which may not always correspond to the priority of the users. In many cases, practitioners and researchers in different fields, going from…

Analyzing large datasets to select optimal features is one of the most important research areas in machine learning and data mining. This feature selection procedure involves dimensionality reduction which is crucial in enhancing the…

Neural and Evolutionary Computing · Computer Science 2024-09-24 Zhila Yaseen Taha , Abdulhady Abas Abdullah , Tarik A. Rashid