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In the paradigm of thermodynamic computing, instead of behaving deterministically, hardware undergoes a stochastic process in order to sample from a distribution of interest. While it has been hypothesized that thermodynamic computers may…

Making decisions freely presupposes that there is some indeterminacy in the environment and in the decision making engine. The former is reflected on the behavioral changes due to communicating: few changes indicate rigid environments;…

Artificial Intelligence · Computer Science 2020-09-23 Luis A. Pineda

Living cells use readout molecules to record the state of receptor proteins, similar to measurements or copies in typical computational devices. But is this analogy rigorous? Can cells be optimally efficient, and if not, why? We show that,…

Molecular Networks · Quantitative Biology 2017-04-12 Thomas E. Ouldridge , Christopher C. Govern , Pieter Rein ten Wolde

Biology stores information and computes at the molecular scale, yet the ways in which it does so are often distinct from human-engineered computers. Mapping biological computation onto architectures familiar to computer science remains an…

Biological Physics · Physics 2026-03-31 Jan Kocka , Kabir Husain , Jaime Agudo-Canalejo

Many biological decision-making processes can be viewed as performing a classification task over a set of inputs, using various chemical and physical processes as "biological hardware." In this context, it is important to understand the…

Disordered Systems and Neural Networks · Physics 2024-09-10 Carlos Floyd , Aaron R. Dinner , Arvind Murugan , Suriyanarayanan Vaikuntanathan

The high energy consumption of electronic data processors, together with physical challenges limiting their further improvement, has triggered intensive interest in alternative computation paradigms. Here we focus on network-based…

Provided that there is no theoretical frame for complex engineered systems (CES) as yet, this paper claims that bio-inspired engineering can help provide such a frame. Within CES bio-inspired systems play a key role. The disclosure from…

Other Computer Science · Computer Science 2011-10-18 Nelson Alfonso Gómez-Cruz , Carlos Eduardo Maldonado

Nonequilibrium processes break time-reversal symmetry and generate entropy. Living systems are driven out-of-equilibrium at the microscopic level of molecular motors that exploit chemical potential gradients to transduce free energy to…

Statistical Mechanics · Physics 2022-12-06 Eden Nitzan , Aishani Ghosal , Gili Bisker

Strand displacement and tile assembly systems are designed to follow prescribed kinetic rules (i.e., exhibit a specific time-evolution). However, the expected behavior in the limit of infinite time--known as thermodynamic equilibrium--is…

Emerging Technologies · Computer Science 2017-09-26 David Doty , Trent A. Rogers , David Soloveichik , Chris Thachuk , Damien Woods

One of the major resource requirements of computers - ranging from biological cells to human brains to high-performance (engineered) computers - is the energy used to run them. Those costs of performing a computation have long been a focus…

Statistical Mechanics · Physics 2025-08-06 David H. Wolpert

Computers are deterministic dynamical systems (CHAOS 19:033124, 2009). Among other things, that implies that one should be able to use deterministic forecast rules to predict their behavior. That statement is sometimes-but not always-true.…

Chaotic Dynamics · Physics 2013-05-24 Joshua Garland , Ryan James , Elizabeth Bradley

It is now well established that there is no lower bound for the energy dissipated during a computation. The relevance of the zero-energy limit is unclear, however, because it entails computations that are unreliable or infinitely slow, or…

Statistical Mechanics · Physics 2018-02-21 Dominique Chu

The promise of chemical computation lies in controlling systems incompatible with traditional electronic micro-controllers, with applications in synthetic biology and nano-scale manufacturing. Computation is typically embedded in…

Emerging Technologies · Computer Science 2019-02-11 Keenan Breik , Chris Thachuk , Marijn Heule , David Soloveichik

Cells can be considered as systems that utilize changes in thermodynamic entropy as information. Therefore, they serve as useful models for investigating the relationships between entropy production and information transmission, i.e.,…

Molecular Networks · Quantitative Biology 2017-03-09 Tatsuaki Tsuruyama

Biological organisms must perform computation as they grow, reproduce, and evolve. Moreover, ever since Landauer's bound was proposed it has been known that all computation has some thermodynamic cost -- and that the same computation can be…

Other Quantitative Biology · Quantitative Biology 2018-02-07 Christopher P. Kempes , David Wolpert , Zachary Cohen , Juan Pérez-Mercader

In quantum chemistry, the price paid by all known efficient model chemistries is either the truncation of the Hilbert space or uncontrolled approximations. Theoretical computer science suggests that these restrictions are not mere…

Chemical Physics · Physics 2017-03-15 James D. Whitfield , Peter J. Love , Alan Aspuru-Guzik

Living systems efficiently use chemical fuel to do work, process information, and assemble patterns despite thermal noise. Whether high efficiency arises from general principles or specific fine-tuning is unknown. Here, applying a recent…

Biological Physics · Physics 2022-10-11 Milo M Lin

In various chemical systems enthalpy-entropy compensation (EEC) is a well-known rule of behavior, although the physical roots of it are still not completely understood. It has been frequently questioned whether EEC is a truly physical…

Statistical Mechanics · Physics 2015-06-04 E. B. Starikov , B. Norden

We propose a dedicated model to assist with the life cycle analysis of emissions of scientific computing centres. The model takes into account both the embodied carbon and emissions from use, as well as other factors such as data centre…

High Energy Physics - Experiment · Physics 2025-10-03 Wim Vanderbauwhede , Mattias Wadenstein

Real-world computers have operational constraints that cause nonzero entropy production (EP). In particular, almost all real-world computers are ``periodic'', iteratively undergoing the same physical process; and ``local", in that…

Statistical Mechanics · Physics 2023-07-06 Thomas E. Ouldridge , David H. Wolpert
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