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Patient scans from MRI often suffer from noise, which hampers the diagnostic capability of such images. As a method to mitigate such artifact, denoising is largely studied both within the medical imaging community and beyond the community…

Magnetic Resonance Imaging (MRI) is a widely used medical imaging technique, but its long acquisition time can be a limiting factor in clinical settings. To address this issue, researchers have been exploring ways to reduce the acquisition…

Speed-of-sound has been shown as a potential biomarker for breast cancer imaging, successfully differentiating malignant tumors from benign ones. Speed-of-sound images can be reconstructed from time-of-flight measurements from ultrasound…

Because optical systems have huge bandwidth and are capable of generating low noise short pulses they are ideal for undersampling multi-band signals that are located within a very broad frequency range. In this paper we propose a new scheme…

This dissertation is devoted to provide advanced nonconvex nonsmooth variational models of (Magnetic Resonance Image) MRI reconstruction, efficient learnable image reconstruction algorithms and parameter training algorithms that improve the…

RF pulse design via optimal control is typically based on gradient and quasi-Newton approaches and therefore suffers from slow convergence. We present a flexible and highly efficient method that uses exact second-order information within a…

The goals of functional Magnetic Resonance Imaging (fMRI) include high spatial and temporal resolutions with a high signal-to-noise ratio (SNR). To simultaneously improve spatial and temporal resolutions and maintain the high SNR advantage…

Motion remains a major challenge in magnetic resonance (MR) imaging, particularly in free-breathing cardiac MR imaging, where data are acquired over multiple heartbeats at varying respiratory phases. We adopt a model-based approach for…

Reducing MRI scan times can improve patient care and lower healthcare costs. Many acceleration methods are designed to reconstruct diagnostic-quality images from sparse k-space data, via an ill-posed or ill-conditioned linear inverse…

Magnetic Resonance Imaging (MRI) is a non-invasive diagnostic tool that provides excellent soft-tissue contrast without the use of ionizing radiation. Compared to other clinical imaging modalities (e.g., CT or ultrasound), however, the data…

We present novel reconstruction and stability analysis methodologies for two-dimensional, multi-coil MRI, based on analytic continuation ideas. We show that the 2-D, limited-data MRI inverse problem, whereby the missing parts of…

Objective: To propose and validate an unsupervised MRI reconstruction method that does not require fully sampled k-space data. Materials and Methods: The proposed method, deep image prior with structured sparsity (DISCUS), extends the deep…

Fast and sensitive detector arrays enable image scanning microscopy (ISM), overcoming the trade-off between spatial resolution and signal-to-noise ratio (SNR) typical of confocal microscopy. However, current ISM approaches cannot provide…

With the advent of multi-coil imaging and compressed sensing, a number of model based reconstruction algorithms have been created. They incorporate a multitude of different regularization functions based on physics, observed phenomenology,…

Deep-learning-based brain magnetic resonance imaging (MRI) reconstruction methods have the potential to accelerate the MRI acquisition process. Nevertheless, the scientific community lacks appropriate benchmarks to assess MRI reconstruction…

We present a new two-snapshot structured light illumination (SLI) reconstruction algorithm for fast image acquisition. The new algorithm, which only requires two mutually {\pi} phase-shifted raw structured images, is implemented on a…

Motion artifacts are a pervasive problem in MRI, leading to misdiagnosis or mischaracterization in population-level imaging studies. Current retrospective rigid intra-slice motion correction techniques jointly optimize estimates of the…

Magnetic resonance imaging (MRI) is an essential diagnostic tool that suffers from prolonged scan time. To alleviate this limitation, advanced fast MRI technology attracts extensive research interests. Recent deep learning has shown its…

Clinical MRI frequently acquires anisotropic volumes with high in-plane resolution and low through-plane resolution to reduce acquisition time. Multiple orientations are therefore acquired to provide complementary anatomical information.…

Multiple sclerosis is one of the most common chronic neurological diseases affecting the central nervous system. Lesions produced by the MS can be observed through two modalities of magnetic resonance (MR), known as T2W and FLAIR sequences,…