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There has been an intense development of Bayes graphical model estimation approaches over the past decade - however, most of the existing methods are restricted to moderate dimensions. We propose a novel approach suitable for high…

Methodology · Statistics 2013-08-20 Suprateek Kundu , Veera Baladandayuthapani , Bani K. Mallick

In the course of evolution, proteins show a remarkable conservation of their three-dimensional structure and their biological function, leading to strong evolutionary constraints on the sequence variability between homologous proteins. Our…

Quantitative Methods · Quantitative Biology 2014-04-07 Carlo Baldassi , Marco Zamparo , Christoph Feinauer , Andrea Procaccini , Riccardo Zecchina , Martin Weigt , Andrea Pagnani

In this paper, we propose a class of Bayes estimators for the covariance matrix of graphical Gaussian models Markov with respect to a decomposable graph $G$. Working with the $W_{P_G}$ family defined by Letac and Massam [Ann. Statist. 35…

Statistics Theory · Mathematics 2009-01-22 Bala Rajaratnam , Hélène Massam , Carlos M. Carvalho

We develop a new estimator of the inverse covariance matrix for high-dimensional multivariate normal data using the horseshoe prior. The proposed graphical horseshoe estimator has attractive properties compared to other popular estimators,…

Methodology · Statistics 2019-01-08 Yunfan Li , Bruce A. Craig , Anindya Bhadra

To capture the death rates and strong weekly, biweekly and probably monthly patterns in the Canada COVID-19, we utilize the generalized additive models in the absence of direct statistically based measurement of infection rates. By…

Applications · Statistics 2020-08-04 Farzali Izadi

Bayesian statistical inference for Generalized Linear Models (GLMs) with parameters lying on a constrained space is of general interest (e.g., in monotonic or convex regression), but often constructing valid prior distributions supported on…

Methodology · Statistics 2021-09-02 Rahul Ghosal , Sujit K. Ghosh

Generalized additive models (GAMs) are flexible non-linear regression models, which can be fitted efficiently using the approximate Bayesian methods provided by the mgcv R package. While the GAM methods provided by mgcv are based on the…

Methodology · Statistics 2020-07-08 Matteo Fasiolo , Simon N. Wood , Margaux Zaffran , Raphaël Nedellec , Yannig Goude

For the problem of inferring a Gaussian graphical model (GGM), this work explores the application of a recent approach from the multiple testing literature for graph inference. The main idea of the method by Rebafka et al. (2022) is to…

Methodology · Statistics 2024-03-01 Valentin Kilian , Tabea Rebafka , Fanny Villers

Gaussian Markov random fields (GMRFs) are probabilistic graphical models widely used in spatial statistics and related fields to model dependencies over spatial structures. We establish a formal connection between GMRFs and convolutional…

Machine Learning · Statistics 2020-08-11 Per Sidén , Fredrik Lindsten

Functional connectivity analysis is an important tool for characterizing interactions among brain regions, particularly in studies of neurodegenerative disorders such as Alzheimer's disease (AD). Gaussian graphical models (GGMs) provide a…

Methodology · Statistics 2026-04-14 Panpan Zhang , Shiying Xiao , W. Hudson Robb , Dandan Liu , Angela L. Jefferson , Jun Yan

High-dimensional networks play a key role in understanding complex relationships. These relationships are often dynamic in nature and can change with multiple external factors (e.g., time and groups). Methods for estimating graphical models…

Methodology · Statistics 2024-07-30 Louis Dijkstra , Arne Godt , Ronja Foraita

Bayesian graphical models are a useful tool for understanding dependence relationships among many variables, particularly in situations with external prior information. In high-dimensional settings, the space of possible graphs becomes…

Machine Learning · Statistics 2019-02-07 Zehang Richard Li , Tyler H. McCormick

A computationally simple genome-wide association study (GWAS) algorithm for estimating the main and epistatic effects of markers or single nucleotide polymorphisms (SNPs) is proposed. It is based on the intuitive assumption that changes of…

Quantitative Methods · Quantitative Biology 2017-08-08 Lev V. Utkin , Irina L. Utkina

Mixtures of Gaussian Bayesian networks have previously been studied under full-covariance assumptions, where each mixture component has its own covariance matrix. We propose a mixture model with tied-covariance, in which all components…

Computation · Statistics 2025-11-11 Marco Grzegorczyk

We propose to learn latent graphical models when data have mixed variables and missing values. This model could be used for further data analysis, including regression, classification, ranking etc. It also could be used for imputing missing…

Methodology · Statistics 2015-11-17 Xiao Li , Jinzhu Jia , Yuan Yao

We use Bayesian model selection paradigms, such as group least absolute shrinkage and selection operator priors, to facilitate generalized additive model selection. Our approach allows for the effects of continuous predictors to be…

Methodology · Statistics 2023-09-29 Virginia X. He , Matt P. Wand

In many transcriptomic studies, the correlation of genes might fluctuate with quantitative factors such as genetic ancestry. We propose a method that models the covariance between two variables to vary against a continuous covariate. For…

Methodology · Statistics 2021-05-03 Tae Hyun Kim , Dan Nicolae

Undirected graphical models, or Markov networks, are a popular class of statistical models, used in a wide variety of applications. Popular instances of this class include Gaussian graphical models and Ising models. In many settings,…

Statistics Theory · Mathematics 2015-09-08 Eunho Yang , Pradeep Ravikumar , Genevera I. Allen , Zhandong Liu

Graphs from complex systems often share a partial underlying structure across domains while retaining individual features. Thus, identifying common structures can shed light on the underlying signal, for instance, when applied to scientific…

Methodology · Statistics 2022-04-05 Katherine Tsai , Oluwasanmi Koyejo , Mladen Kolar

Sparse covariance matrices play crucial roles by encoding the interdependencies between variables in numerous fields such as genetics and neuroscience. Despite substantial studies on sparse covariance matrices, existing methods face several…

Methodology · Statistics 2026-03-03 Rakheon Kim , Irina Gaynanova