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The anatomical location of imaging features is of crucial importance for accurate diagnosis in many medical tasks. Convolutional neural networks (CNN) have had huge successes in computer vision, but they lack the natural ability to…

Computer Vision and Pattern Recognition · Computer Science 2016-11-01 Mohsen Ghafoorian , Nico Karssemeijer , Tom Heskes , Inge van Uden , Clara Sanchez , Geert Litjens , Frank-Erik de Leeuw , Bram van Ginneken , Elena Marchiori , Bram Platel

Convolutional Neural Networks (CNNs) have achieved remarkable success across a wide range of machine learning tasks by leveraging hierarchical feature learning through deep architectures. However, the large number of layers and millions of…

Machine Learning · Statistics 2025-11-18 Biyi Fang , Truong Vo , Jean Utke , Diego Klabjan

Predicting ATP-Protein Binding sites in genes is of great significance in the field of Biology and Medicine. The majority of research in this field has been conducted through time- and resource-intensive 'wet experiments' in laboratories.…

Biomolecules · Quantitative Biology 2024-02-06 Shreyas V , Swati Agarwal

Friction Stir Welding is a robust joining process, and numerous AI-based algorithms are being developed in this field to enhance mechanical and microstructure properties. Convolutional Neural Networks (CNNs) are Artificial Neural Networks…

Computer Vision and Pattern Recognition · Computer Science 2022-03-18 Akshansh Mishra , Asmita Suman , Devarrishi Dixit

This paper presents the methods that have participated in the SHREC 2022 contest on protein-ligand binding site recognition. The prediction of protein-ligand binding regions is an active research domain in computational biophysics and…

The computational prediction of a protein structure from its sequence generally relies on a method to assess the quality of protein models. Most assessment methods rank candidate models using heavily engineered structural features, defined…

Biomolecules · Quantitative Biology 2018-11-26 Georgy Derevyanko , Sergei Grudinin , Yoshua Bengio , Guillaume Lamoureux

In this paper we address the problem of protein classification starting from a multi-view 2D representation of proteins. From each 3D protein structure, a large set of 2D projections is generated using the protein visualization software…

Computer Vision and Pattern Recognition · Computer Science 2019-10-30 Loris Nanni , Alessandra Lumini , Federica Pasquali , Sheryl Brahnam

Protein structural classification (PSC) is a supervised problem of assigning proteins into pre-defined structural (e.g., CATH or SCOPe) classes based on the proteins' sequence or 3D structural features. We recently proposed PSC approaches…

Molecular Networks · Quantitative Biology 2021-05-18 Khalique Newaz , Jacob Piland , Patricia L. Clark , Scott J. Emrich , Jun Li , Tijana Milenkovic

The generation of small molecule candidate (ligand) binding poses in its target protein pocket is important for computer-aided drug discovery. Typical rigid-body docking methods ignore the pocket flexibility of protein, while the more…

Neural and Evolutionary Computing · Computer Science 2023-08-03 Jonathan P. Mailoa , Zhaofeng Ye , Jiezhong Qiu , Chang-Yu Hsieh , Shengyu Zhang

Achieving robust multi-person 2D body landmark localization and pose estimation is essential for human behavior and interaction understanding as encountered for instance in HRI settings. Accurate methods have been proposed recently, but…

Computer Vision and Pattern Recognition · Computer Science 2019-12-03 Angel Martínez-González , Michael Villamizar , Olivier Canévet , Jean-Marc Odobez

Deep neural networks, albeit their great success on feature learning in various computer vision tasks, are usually considered as impractical for online visual tracking because they require very long training time and a large number of…

Computer Vision and Pattern Recognition · Computer Science 2016-05-04 Hanxi Li , Yi Li , Fatih Porikli

Predicting the binding sites of target proteins plays a fundamental role in drug discovery. Most existing deep-learning methods consider a protein as a 3D image by spatially clustering its atoms into voxels and then feed the voxelized…

Biomolecules · Quantitative Biology 2024-07-24 Yang Zhang , Zhewei Wei , Ye Yuan , Chongxuan Li , Wenbing Huang

Proteins are miniature machines whose function depends on their three-dimensional (3D) structure. Determining this structure computationally remains an unsolved grand challenge. A major bottleneck involves selecting the most accurate…

Quantitative Methods · Quantitative Biology 2020-11-30 Stephan Eismann , Patricia Suriana , Bowen Jing , Raphael J. L. Townshend , Ron O. Dror

Convolutional neural networks (CNNs) learn abstract features to perform object classification, but understanding these features remains challenging due to difficult-to-interpret results or high computational costs. We propose an automatic…

Computer Vision and Pattern Recognition · Computer Science 2024-09-26 Maren H. Wehrheim , Pamela Osuna-Vargas , Matthias Kaschube

Motivation: Recognizing human actions in a video is a challenging task which has applications in various fields. Previous works in this area have either used images from a 2D or 3D camera. Few have used the idea that human actions can be…

Computer Vision and Pattern Recognition · Computer Science 2016-12-21 Adhavan Jayabalan , Harish Karunakaran , Shravan Murlidharan , Tesia Shizume

The convolutional neural network (CNN) has become a powerful tool for various biomedical image analysis tasks, but there is a lack of visual explanation for the machinery of CNNs. In this paper, we present a novel algorithm,…

Computer Vision and Pattern Recognition · Computer Science 2018-06-08 Guannan Zhao , Bo Zhou , Kaiwen Wang , Rui Jiang , Min Xu

Recognition and binding of specific sites on DNA by proteins is central for many cellular functions such as transcription, replication, and recombination. In the process of recognition, a protein rapidly searches for its specific site on a…

Biomolecules · Quantitative Biology 2007-05-23 Michael Slutsky , Leonid A. Mirny

In drug discovery, molecular dynamics (MD) simulation for protein-ligand binding provides a powerful tool for predicting binding affinities, estimating transport properties, and exploring pocket sites. There has been a long history of…

Given a pedestrian image as a query, the purpose of person re-identification is to identify the correct match from a large collection of gallery images depicting the same person captured by disjoint camera views. The critical challenge is…

Computer Vision and Pattern Recognition · Computer Science 2017-12-05 Lin Wu , Yang Wang

In this work we present a system based on a Deep Learning approach, by using a Convolutional Neural Network, capable of classifying protein chains of amino acids based on the protein description contained in the Protein Data Bank. Each…

Machine Learning · Computer Science 2021-11-04 Damiano Perri , Marco Simonetti , Andrea Lombardi , Noelia Faginas-Lago , Osvaldo Gervasi
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