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This chapter presents reduced-rank linearly constrained minimum variance (LCMV) algorithms based on the concept of joint iterative optimization of parameters. The proposed reduced-rank scheme is based on a constrained robust joint iterative…

Information Theory · Computer Science 2013-02-12 R. C. de Lamare

Radiation Treatment Planning (RTP) is the process of planning the appropriate external beam radiotherapy to combat cancer in human patients. RTP is a complex and compute-intensive task, which often takes a long time (several hours) to…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-09-21 Felix Liu , Niclas Jansson , Artur Podobas , Albin Fredriksson , Stefano Markidis

Anatomical changes during intensity-modulated proton therapy (IMPT) for head-and-neck cancer (HNC) can shift Bragg peaks, risking tumor underdosing and organ-at-risk overdosing. Treatment replanning is often required to maintain clinically…

Medical Physics · Physics 2025-08-13 Malvern Madondo , Yuan Shao , Yingzi Liu , Jun Zhou , Xiaofeng Yang , Zhen Tian

The interplay between the beam delivery time structure and the patient motion makes 4D dose calculation (4DDC) important when treating moving tumors with intensity modulated proton therapy. 4DDC based on phase sorting of a 4DCT suffers from…

Medical Physics · Physics 2023-10-13 Ivar Bengtsson , Erik Engwall , Albin Fredriksson , Lars Glimelius

Positive linear programs (LP), also known as packing and covering linear programs, are an important class of problems that bridges computer science, operations research, and optimization. Despite the consistent efforts on this problem, all…

Data Structures and Algorithms · Computer Science 2016-11-15 Zeyuan Allen-Zhu , Lorenzo Orecchia

We study a continuous-time portfolio optimization problem under an explicit constraint on the Deviation Conditional Value-at-Risk (DCVaR), defined as the difference between the CVaR and the expected terminal wealth. While the mean-CVaR…

Optimization and Control · Mathematics 2025-10-01 Jérôme Lelong , Véronique Maume-Deschamps , William Thevenot

This paper studies the infinite-horizon adaptive optimal control of continuous-time linear periodic (CTLP) systems. A novel value iteration (VI) based off-policy ADP algorithm is proposed for a general class of CTLP systems, so that…

Systems and Control · Electrical Eng. & Systems 2024-12-20 Bo Pang , Zhong-Ping Jiang

Recent progress in randomized motion planners has led to the development of a new class of sampling-based algorithms that provide asymptotic optimality guarantees, notably the RRT* and the PRM* algorithms. Careful analysis reveals that the…

Robotics · Computer Science 2016-09-21 Oktay Arslan , Panagiotis Tsiotras

Computer-Aided Diagnosis and Treatment of Tumors is a hot topic of deep learning in recent years, which constitutes a series of medical tasks, such as detection of tumor markers, the outline of tumor leisures, subtypes and stages of tumors,…

Image and Video Processing · Electrical Eng. & Systems 2020-11-03 Dan Zhao , Guizhi Xu , Zhenghua XU , Thomas Lukasiewicz , Minmin Xue , Zhigang Fu

We give a link to a page on the Web on which we deposited a set of eight huge Linear Programming (LP) problems for Intensity-Modulated Proton Therapy (IMPT) treatment planning. These huge LP problems were employed in our recent research and…

Mathematical Software · Computer Science 2011-03-16 Wei Chen

This paper presents reduced-rank linearly constrained minimum variance (LCMV) beamforming algorithms based on joint iterative optimization of filters. The proposed reduced-rank scheme is based on a constrained joint iterative optimization…

Other Computer Science · Computer Science 2012-05-22 R. C. de Lamare , L. Wang , R. Fa

Proton therapy offers significant advantages due to its unique physical and biological properties, particularly the Bragg peak, enabling precise dose delivery to tumors while sparing healthy tissues. However, the clinical implementation is…

In post-operative radiotherapy for prostate cancer, the cancerous prostate gland has been surgically removed, so the clinical target volume (CTV) to be irradiated encompasses the microscopic spread of tumor cells, which cannot be visualized…

Constrained convex optimization problems arise naturally in many real-world applications. One strategy to solve them in an approximate way is to translate them into a sequence of convex feasibility problems via the recently developed level…

Optimization and Control · Mathematics 2019-04-30 E. Bonacker , A. Gibali , K. -H. Küfer

In this letter, we develop an efficient linear programming (LP) decoding algorithm for low-density parity-check (LDPC) codes. We first relax the maximum likelihood (ML) decoding problem to a LP problem by using check-node decomposition.…

Information Theory · Computer Science 2019-01-24 Jing Bai , Yongchao Wang , Francis C. M. Lau

The problem of finding the optimal portfolio for investors is called the portfolio optimization problem. Such problem mainly concerns the expectation and variability of return (i.e., mean and variance). Although the variance would be the…

Portfolio Management · Quantitative Finance 2020-07-21 Kei Nakagawa , Shuhei Noma , Masaya Abe

Inverse planning algorithms for dwell time optimisation in interstitial high-dose-rate (HDR) brachytherapy may produce solutions with large dwell time variations within catheters, which may result in undesirable selective high-dose…

Medical Physics · Physics 2016-03-14 Marleen Balvert , Bram Gorissen , Dick den Hertog , Aswin Hoffmann

Radiotherapy planning is a critical aspect of cancer treatment, where the optimal selection of beam directions and dose distributions significantly impacts treatment efficacy and patient outcomes. Traditionally, this process involves…

Medical Physics · Physics 2023-12-05 Keshav Kumar K. , NVSL Narasimham , A. Ramakrishna Prasad

Purpose: To improve target coverage and reduce the dose in the surrounding organs-at-risks (OARs), we developed an image-guided treatment method based on a precomputed library of treatment plans controlled and delivered in real-time.…

Medical Physics · Physics 2022-11-02 Valentin Hamaide , Kevin Souris , Damien Dasnoy , Francois Glineur , Benoit Macq

Oncolytic virotherapy (OV) has been emerging as a promising novel cancer treatment that may be further combined with the existing therapeutic modalities to enhance their effects. To investigate how OV could enhance chemotherapy, we propose…

Optimization and Control · Mathematics 2018-09-24 Joseph Malinzi , Rachid Ouifki , Amina Eladdadi , Delfim F. M. Torres , K. A. Jane White
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