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The emerging technique of mid-infrared optical coherence tomography (MIR-OCT) takes advantage of the reduced scattering of MIR light in various materials and devices, enabling tomographic imaging at deeper penetration depths. Because of…

Label-free tomographic microscopy offers a compelling means to visualize three-dimensional (3D) refractive index (RI) distributions from two-dimensional (2D) intensity measurements. However, limited forward-model accuracy and the ill-posed…

Optics · Physics 2025-02-27 Delong Yang , Shaohui Zhang , Jiasong Sun , Chao Zuo , Qun Hao

Fast, reprogrammable control over the transverse structure of light beams plays an essential role in applications such as structured illumination microscopy, optical trapping, and quantum information processing. Existing technologies, such…

Cells alter the path of light, a fact that leads to well-known aberrations in single cell or tissue imaging. Optical diffraction tomography (ODT) measures the biophysical property that causes these aberrations, the refractive index (RI).…

Quantitative Methods · Quantitative Biology 2017-08-14 Mirjam Schürmann , Gheorghe Cojoc , Salvatore Girardo , Elke Ulbricht , Jochen Guck , Paul Müller

This paper presents a new FDTD-based optical simulation model dedicated to describe the optical performances of CMOS image sensors taking into account diffraction effects. Following market trend and industrialization constraints, CMOS image…

Optics · Physics 2023-10-17 Flavien Hirigoyen , Axel Crocherie , Jérôme Vaillant , Yvon Cazaux

Micromechanical transducers such as cantilevers for AFM often rely on optical readout methods that require illumination of a specific region of the microstructure. Here we explore and exploit the diffraction effects that have been…

Instrumentation and Detectors · Physics 2016-06-06 Rodolfo I. Hermans , Benjamin Dueck , Joseph Wafula Ndieyira , Rachel A. McKendry , Gabriel Aeppli

We introduce a novel reflection-mode diffraction tomography technique that enables simultaneous recovery of forward and backward scattering information for high-resolution 3D refractive index reconstruction. Our technique works by imaging a…

Optics · Physics 2025-02-12 Tongyu Li , Jiabei Zhu , Yi Shen , Lei Tian

Out-of-distribution (OOD) detection is crucial for the safety and reliability of artificial intelligence algorithms, especially in the medical domain. In the context of the Medical OOD (MOOD) detection challenge 2023, we propose a pipeline…

Computer Vision and Pattern Recognition · Computer Science 2023-10-16 Evi M. C. Huijben , Sina Amirrajab , Josien P. W. Pluim

In Optical diffraction tomography, the multiply scattered field is a nonlinear function of the refractive index of the object. The Rytov method is a linear approximation of the forward model, and is commonly used to reconstruct images.…

We use a spatial light modulator in a diffraction tomographic system to assess the accuracy of different refractive index reconstruction algorithms. Optical phase conjugation principles through complex media, allows us to quantify the error…

Three-dimensional imaging of biological cells is crucial for the investigation of cell biology, provide valuable information to reveal the mechanisms behind pathophysiology of cells and tissues. Recent advances in optical diffraction…

Biological Physics · Physics 2016-03-03 Kyoohyun Kim , Jonghee Yoon , Seungwoo Shin , SangYun Lee , Su-A Yang , YongKeun Park

Aero-optical beam control relies on the development of low-latency forecasting techniques to quickly predict wavefronts aberrated by the Turbulent Boundary Layer (TBL) around an airborne optical system, and its study applies to a…

Holographic beam shaping is a powerful approach for generating individually addressable optical spots for controlling atomic qubits, such as those in trapped-ion quantum processors. However, its application in qubit control is limited by…

Quantum Physics · Physics 2025-12-17 Shilpa Mahato , Rajibul Islam

Diffuse optical breast imaging utilizes near-infrared (NIR) light propagation through tissues to assess the optical properties of tissue for the identification of abnormal tissue. This optical imaging approach is sensitive, cost-effective,…

Medical Physics · Physics 2017-11-22 Wenxiang Cong , Xavier Intes , Ge Wang

Optical trapping can be used to manipulate the three-dimensional (3-D) motion of spherical particles based on the simple prediction of optical forces and the responding motion of samples. However, controlling the 3-D behaviour of…

Optics · Physics 2017-06-28 Kyoohyun Kim , YongKeun Park

A broad class of imaging modalities involve the resolution of an inverse-scattering problem. Among them, three-dimensional optical diffraction tomography (ODT) comes with its own challenges. These include a limited range of views, a large…

Image and Video Processing · Electrical Eng. & Systems 2020-04-20 Thanh-an Pham , Emmanuel Soubies , Ahmed Ayoub , Joowon Lim , Demetri Psaltis , Michael Unser

A new formulation of lateral imaging process of point-scanning optical coherence tomography (OCT) and a new differential contrast method designed by using this formulation are presented. The formulation is based on a mathematical sample…

This article presents a method to perform diffraction tomography in a standard microscope that includes an LED array for illumination. After acquiring a sequence of intensity-only images of a thick sample, a ptychography-based…

Optics · Physics 2015-10-30 Roarke Horstmeyer , Changhuei Yang

Simultaneous imaging of fluorescence-labeled and label-free phase objects in the same sample provides distinct and complementary information. Most multimodal fluorescence-phase imaging operates in transmission mode, capturing fluorescence…

Optics · Physics 2024-08-20 Renzhi He , Yucheng Li , Junjie Chen , Yi Xue

We demonstrate a motion-free intensity diffraction tomography technique that enables direct inversion of 3D phase and absorption from intensity-only measurements for weakly scattering samples. We derive a novel linear forward model,…

Image and Video Processing · Electrical Eng. & Systems 2018-06-26 Ruilong Ling , Waleed Tahir , Hsing-Ying Lin , Hakho Lee , Lei Tian