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We propose a novel approach to generate samples from the conditional distribution of patient-specific cardiovascular models given a clinically aquired image volume. A convolutional neural network architecture with dropout layers is first…

Quantitative Methods · Quantitative Biology 2021-09-01 Gabriel Maher , Casey Fleeter , Daniele Schiavazzi , Alison Marsden

Numerous are the questionings raised by medicine interventionnelle, concerning the hold in charge of the pathologies of the arterial partition (aneurysm, dissection, coarctation, atherosclerosis).for it we made the modeling and the numeric…

Fluid Dynamics · Physics 2009-06-29 H . Alla , M. S. Gueblaoui , M. H. Bensaid

The development and progression of abdominal aortic aneurysms (AAA) are related to complex flow patterns and wall-shear-driven mechanobiological stimuli, yet the quantitative relationship between aneurysmal geometry and hemodynamics remains…

Coronary heart disease (CHD) remains a top reason of mortality worldwide. This study introduces a novel approach by integrating patient-specific Multi-slice CT scans into CAD models and employing a one-dimensional numerical framework to…

Medical Physics · Physics 2025-07-01 Oeshee Roy , Priyanshu Ghosh , Sayan Karmakar , Supratim Saha

This study performs parameter inference in a partial differential equations system of pulmonary circulation. We use a fluid dynamics network model that takes selected parameter values and mimics the behaviour of the pulmonary haemodynamics…

Computational fluid dynamics (CFD) can be used to simulate vascular haemodynamics and analyse potential treatment options. CFD has shown to be beneficial in improving patient outcomes. However, the implementation of CFD for routine clinical…

Hemodynamic parameters such as pressure and wall shear stress play an important role in diagnosis, prognosis, and treatment planning in cardiovascular diseases. These parameters can be accurately computed using computational fluid dynamics…

Computer Vision and Pattern Recognition · Computer Science 2025-08-28 Patryk Rygiel , Julian Suk , Kak Khee Yeung , Christoph Brune , Jelmer M. Wolterink

An arteriovenous fistula, created by artificially connecting segments of a patient's vasculature, is the preferred way to gain access to the bloodstream for kidney dialysis. The increasing power and availability of supercomputing…

Medical Physics · Physics 2021-06-14 J. W. S. McCullough , P. V. Coveney

In this work the development of a machine learning-based Reduced Order Model (ROM) for the investigation of hemodynamics in a patient-specific configuration of Coronary Artery Bypass Graft (CABG) is proposed. The computational domain is…

Medical Physics · Physics 2023-08-08 Pierfrancesco Siena , Michele Girfoglio , Francesco Ballarin , Gianluigi Rozza

Rule-based methods are often used for assigning fiber orientation to cardiac anatomical models. However, existing methods have been developed using data mostly from the left ventricle. As a consequence, fiber information obtained from…

Blood vessel networks, represented as 3D graphs, help predict disease biomarkers, simulate blood flow, and aid in synthetic image generation, relevant in both clinical and pre-clinical settings. However, generating realistic vessel graphs…

Computer Vision and Pattern Recognition · Computer Science 2024-07-09 Chinmay Prabhakar , Suprosanna Shit , Fabio Musio , Kaiyuan Yang , Tamaz Amiranashvili , Johannes C. Paetzold , Hongwei Bran Li , Bjoern Menze

To address the issue of computational efficiency related to the modelling of blood flow in complex networks, we derive a family of nonlinear lumped-parameter models for blood flow in compliant vessels departing from a well-established…

Numerical Analysis · Mathematics 2022-01-06 Beatrice Ghitti , Eleuterio F. Toro , Lucas O. Müller

As experts continue to debate the optimal surgery practice for coronary disease - percutaneous coronary intervention (PCI) or coronary aortic bypass graft (CABG) - computational tools may provide a quantitative assessment of each option.…

Computer Vision and Pattern Recognition · Computer Science 2018-10-09 Boyi Yang , Marina Piccinelli , Gaetano Esposito , Tianli Han , Yasir Bouchi , Bill Gogas , Don Giddens , Habib Samady , Alessandro Veneziani

Currently, it is challenging to investigate aneurismal hemodynamics based on current in-vivo data such as Magnetic Resonance Imaging or Computed Tomography due to the limitations in both spatial and temporal resolutions. In this work, we…

Fluid Dynamics · Physics 2024-10-17 Thien-Tam Nguyen , Davina Kasperski , Phat Kim Huynh , Trung Quoc Le , Trung Bao Le

Detection and monitoring of patients with pulmonary hypertension, defined as mean blood pressure in the main pulmonary artery above 25 mmHg, requires a combination of imaging and hemodynamic measurements. This study demonstrates how to…

Quantitative Methods · Quantitative Biology 2020-02-21 Megan J. Chambers , Mitchel J. Colebank , M Umar Qureshi , Rachel Clipp , Mette S. Olufsen

Whilst grading neurovascular abnormalities is critical for prompt surgical repair, no statistical markers are currently available for predicting the risk of adverse events, such as stroke, and the overall resilience of a network to vascular…

Quantitative Methods · Quantitative Biology 2019-10-30 Stefano Moriconi , Rafael Rehwald , Maria A. Zuluaga , H. Rolf Jäger , Parashkev Nachev , Sébastien Ourselin , M. Jorge Cardoso

In the context of numerical simulations of the vascular system, local geometric uncertainties have not yet been examined in sufficient detail due to model complexity and the associated large numerical effort. Such uncertainties are related…

Generating computational anatomical models of cerebrovascular networks is vital for improving clinical practice and understanding brain oxygen transport. This is achieved by extracting graph-based representations based on pre-mapping of…

Quantitative Methods · Quantitative Biology 2019-12-23 Rafat Damseh , Patrick Delafontaine-Martel , Philippe Pouliot , Farida Cheriet , Frederic Lesage

Abdominal aortic aneurysms (AAAs) are local dilatations in the abdominal aorta occurring due to weakening of arterial wall. The present work investigates the influence of the ratio of maximum transverse diameter to abdominal height (DHr) on…

Fluid Dynamics · Physics 2023-12-05 G. R. Krishna Chand Avatar , Chinika Dangi , Puneet Pushkar

Intracardiac flow patterns are shaped by the coupled motion of the cardiac chambers and heart valves and provide important information about cardiac function. However, clinical flow imaging remains limited by exam times, noise, resolution,…

Image and Video Processing · Electrical Eng. & Systems 2026-05-12 Fanwei Kong , Aaron Brown , Michael Loecher , Perry S. Choi , Lei Shi , Michael Ma , Daniel B. Ennis , Alison Marsden