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We present an approach to model time series data from resting state fMRI for autism spectrum disorder (ASD) severity classification. We propose to adopt kernel machines and employ graph kernels that define a kernel dot product between two…

Machine Learning · Statistics 2016-12-04 Rushil Anirudh , Jayaraman J. Thiagarajan , Irene Kim , Wolfgang Polonik

Brain connectivity networks, which characterize the functional or structural interaction of brain regions, has been widely used for brain disease classification. Kernel-based method, such as graph kernel (i.e., kernel defined on graphs),…

Machine Learning · Computer Science 2021-01-19 Kai Ma , Biao Jie , Daoqiang Zhang

This paper presents a novel graph-based kernel learning approach for connectome analysis. Specifically, we demonstrate how to leverage the naturally available structure within the graph representation to encode prior knowledge in the…

Image and Video Processing · Electrical Eng. & Systems 2022-02-23 Jun Yu , Zhaoming Kong , Aditya Kendre , Hao Peng , Carl Yang , Lichao Sun , Alex Leow , Lifang He

Autism is one of the most important neurological disorders which leads to problems in a person's social interactions. Improvement of brain imaging technologies and techniques help us to build brain structural and functional networks.…

Machine Learning · Computer Science 2021-03-26 Mohammad Amin , Farshad Safaei

In modern relational machine learning it is common to encounter large graphs that arise via interactions or similarities between observations in many domains. Further, in many cases the target entities for analysis are actually signals on…

Autism spectrum disorder (ASD) is one of the most significant neurological disorders that disrupt a person's social communication skills. The progression and development of neuroimaging technologies has made structural network construction…

Social and Information Networks · Computer Science 2019-11-14 M. Amin , F. Safaei , N. S. Ghaderian

While the prevalence of Autism Spectrum Disorder (ASD) is increasing, research continues in an effort to identify common etiological and pathophysiological bases. In this regard, modern machine learning and network science pave the way for…

Image and Video Processing · Electrical Eng. & Systems 2020-08-06 Sarah Itani , Dorina Thanou

In this study, we explore the fundamental principles behind the architecture of the human brain's structural connectome, from the perspective of spectral analysis of Laplacian and adjacency matrices. Building on the idea that the brain…

Neurons and Cognition · Quantitative Biology 2024-05-28 Anna Bobyleva , Alexander Gorsky , Sergei Nechaev , Olga Valba , Nikita Pospelov

While statistical analysis of a single network has received a lot of attention in recent years, with a focus on social networks, analysis of a sample of networks presents its own challenges which require a different set of analytic tools.…

Methodology · Statistics 2019-10-23 Jesús D. Arroyo-Relión , Daniel Kessler , Elizaveta Levina , Stephan F. Taylor

Understanding the intricate architecture of brain networks and its connection to brain function is essential for deciphering the underlying principles of cognition and disease. While traditional graph-theoretical measures have been widely…

Chaotic Dynamics · Physics 2025-11-13 Anca Radulescu , Eva Kaslik , Alexandru Fikl , Johan Nakuci , Sarah Muldoon , Michael Anderson

We propose a model for diagnosing Autism spectrum disorder (ASD) using multimodal magnetic resonance imaging (MRI) data. Our approach integrates brain connectivity data from diffusion tensor imaging (DTI) and functional MRI (fMRI),…

Neurons and Cognition · Quantitative Biology 2024-10-10 Lu Wei , Yi Huang , Guosheng Yin , Fode Zhang , Manxue Zhang , Bin Liu

Out-of-distribution generalization is key to building models that remain reliable across diverse environments. Recent causality-based methods address this challenge by learning invariant causal relationships in the underlying…

Statistics Theory · Mathematics 2025-10-24 Théotime Le Goff , Émilie Devijver

Objective: This paper presents an Alzheimer's disease (AD) detection method based on learning structural similarity between Magnetic Resonance Images (MRIs) and representing this similarity as a graph. Methods: We construct the similarity…

Computer Vision and Pattern Recognition · Computer Science 2021-03-01 Kuo Yang , Emad A. Mohammed , Behrouz H. Far

Due to the ever rising importance of the network paradigm across several areas of science, comparing and classifying graphs represent essential steps in the networks analysis of complex systems. Both tasks have been recently tackled via…

Functional Connectivity (FC) matrices measure the regional interactions in the brain and have been widely used in neurological brain disease classification. However, a FC matrix is neither a natural image which contains shape and texture…

Medical Physics · Physics 2020-01-10 Xiaodan Xing , Qingfeng Li , Hao Wei , Minqing Zhang , Yiqiang Zhan , Xiang Sean Zhou , Zhong Xue , Feng Shi

Cerebellar-like networks, in which input activity patterns are separated by projection to a much higher-dimensional space before classification, are a recurring neurobiological motif, present in the cerebellum, dentate gyrus, insect…

Neurons and Cognition · Quantitative Biology 2026-03-23 William Dorrell , Peter E. Latham

Mining human-brain networks to discover patterns that can be used to discriminate between healthy individuals and patients affected by some neurological disorder, is a fundamental task in neuroscience. Learning simple and interpretable…

Social and Information Networks · Computer Science 2020-06-11 Tommaso Lanciano , Francesco Bonchi , Aristides Gionis

The global functional brain network (graph) is more suitable for characterizing brain states than local analysis of the connectivity of brain regions. Therefore, graph-theoretic approaches are the natural methods to study the brain.…

Supervised deep learning techniques show promise in medical image analysis. However, they require comprehensive annotated data sets, which poses challenges, particularly for rare diseases. Consequently, unsupervised anomaly detection (UAD)…

Image and Video Processing · Electrical Eng. & Systems 2024-03-22 Finn Behrendt , Debayan Bhattacharya , Lennart Maack , Julia Krüger , Roland Opfer , Robin Mieling , Alexander Schlaefer

Positive definite kernels are an important tool in machine learning that enable efficient solutions to otherwise difficult or intractable problems by implicitly linearizing the problem geometry. In this paper we develop a set-theoretic…

Machine Learning · Computer Science 2018-08-22 Andrew Gardner , Christian A. Duncan , Jinko Kanno , Rastko R. Selmic
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