Related papers: Analyzing Genome-wide Association Study Data with …
In order to associate complex traits with genetic polymorphisms, genome-wide association studies process huge datasets involving tens of thousands of individuals genotyped for millions of polymorphisms. When handling these datasets, which…
Assessing the correctness of genome assemblies is an important step in any genome project. Several methods exist, but most are computationally intensive and, in some cases, inappropriate. Here I present baa.pl, a fast and easy-to-use…
Gene expression analysis holds the key to many biomedical discoveries, yet extracting insights from raw transcriptomic data remains formidable due to the complexity of multiple large, semi-structured files and the need for extensive domain…
Probit unfolding models (PUMs) are a novel class of scaling models that allow for items with both monotonic and non-monotonic response functions and have shown great promise in the estimation of preferences from voting data in various…
We present csSampling, an R package for estimation of Bayesian models for data collected from complex survey samples. csSampling combines functionality from the probabilistic programming language Stan (via the rstan and brms R packages) and…
We present a bayesassurance R package that computes the Bayesian assurance under various settings characterized by different assumptions and objectives. The package offers a constructive set of simulation-based functions suitable for…
We present `latentcor`, an R package for correlation estimation from data with mixed variable types. Mixed variables types, including continuous, binary, ordinal, zero-inflated, or truncated data are routinely collected in many areas of…
Motivation: Modelling methods that find structure in data are necessary with the current large volumes of genomic data, and there have been various efforts to find subsets of genes exhibiting consistent patterns over subsets of treatments.…
We introduce cyclinbayes, an open-source R package for discovering linear causal relationships with both acyclic and cyclic structures. The package employs scalable Bayesian approaches with spike-and-slab priors to learn directed acyclic…
Nowadays, the analysis of dynamics in networks represents a great deal in the Social Network Analysis research area. To support students, teachers, developers, and researchers in this work we introduce a novel R package, namely DynComm. It…
Linear mixed models are able to handle an extraordinary range of complications in regression-type analyses. Their most common use is to account for within-subject correlation in longitudinal data analysis. They are also the standard vehicle…
Nowadays, Neural Networks are considered one of the most effective methods for various tasks such as anomaly detection, computer-aided disease detection, or natural language processing. However, these networks suffer from the ``black-box''…
Genomic data arising from a genome-wide association study (GWAS) are often not only of large-scale, but also incomplete. A specific form of their incompleteness is missing values with non-ignorable missingness mechanism. The intrinsic…
There is currently a focus on statistical methods which can use external trial information to help accelerate the discovery, development and delivery of medicine. Bayesian methods facilitate borrowing which is "dynamic" in the sense that…
The R package multgee implements the local odds ratios generalized estimating equations (GEE) approach proposed by Touloumis et al. (2013), a GEE approach for correlated multinomial responses that circumvents theoretical and practical…
A computationally simple genome-wide association study (GWAS) algorithm for estimating the main and epistatic effects of markers or single nucleotide polymorphisms (SNPs) is proposed. It is based on the intuitive assumption that changes of…
Bayesian methods and their implementations by means of sophisticated Monte Carlo techniques, such as Markov chain Monte Carlo (MCMC) and particle filters, have become very popular in signal processing over the last years. However, in many…
The greed package implements the general and flexible framework of arXiv:2002.11577 for model-based clustering in the R language. Based on the direct maximization of the exact Integrated Classification Likelihood with respect to the…
Penalized regression models such as the lasso have been extensively applied to analyzing high-dimensional data sets. However, due to memory limitations, existing R packages like glmnet and ncvreg are not capable of fitting lasso-type models…
The problem of joint estimation of multiple graphical models from high dimensional data has been studied in the statistics and machine learning literature, due to its importance in diverse fields including molecular biology, neuroscience…