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In this paper, we address a social planner's optimal control problem for a partially observable stochastic epidemic model. The control measures include social distancing, testing, and vaccination. Using a diffusion approximation for the…

Optimization and Control · Mathematics 2025-03-11 Ibrahim Mbouandi Njiasse , Florent Ouabo Kamkumo , Ralf Wunderlich

We analyze the optimal control of disease prevention and treatment in a basic SIS model. We develop a simple macroeconomic setup in which the social planner determines how to optimally intervene, through income taxation, in order to…

Theoretical Economics · Economics 2019-10-09 Davide La Torre , Tufail Malik , Simone Marsiglio

We give the explicit solution of the optimal control problem which consists in minimizing the epidemic peak in the SIR model when the control is an attenuation factor of the infectious rate, subject to a L 1 budget constraint. The optimal…

Optimization and Control · Mathematics 2022-03-14 Emilio Molina , Alain Rapaport

In this paper, we study a novel control method for a generalized SIS epidemic process. In particular, we use predictive control to design optimal protective resource distribution strategies which balance the need to eliminate the epidemic…

Optimization and Control · Mathematics 2018-08-17 Nicholas J. Watkins , George J. Pappas

This study presents a deterministic model to investigate rabies transmission dynamics, incorporating environmental effects and control strategies using optimal control theory. Qualitative and quantitative analyses reveal that the…

Optimization and Control · Mathematics 2025-09-05 Mfano Charles , Sayoki G. Mfinanga , G. A. Lyakurwa , Delfim F. M. Torres , Verdiana G. Masanja

We consider the problem of the optimal allocation of vaccination and protection measures for the Susceptible-Infected-Recovered-Infected (SIRI) epidemiological model, which generalizes the classical Susceptible-Infected-Recovered (SIR) and…

Optimization and Control · Mathematics 2025-05-09 Urmee Maitra , Ashish R. Hota , Rohit Gupta , Alfred O. Hero

Understanding historical trends in the epidemic of HIV is important for assessing current and projecting future trends in prevalence, incidence and mortality and for evaluating the impact and cost-effectiveness of control measures. In…

Quantitative Methods · Quantitative Biology 2014-12-10 Brian G. Williams

The process of contagiousness spread modelling is well-known in epidemiology. However, the application of spread modelling to banking market is quite recent. In this work, we present a system of ordinary differential equations, simulating…

Optimization and Control · Mathematics 2018-02-19 Olena Kostylenko , Helena Sofia Rodrigues , Delfim F. M. Torres

HIV-1 can disseminate between susceptible cells by two mechanisms: cell-free infection following fluid-phase diffusion of virions and by highly-efficient direct cell-to-cell transmission at immune cell contacts. The contribution of this…

Populations and Evolution · Quantitative Biology 2024-01-02 Changwang Zhang , Shi Zhou , Elisabetta Groppelli , Pierre Pellegrino , Ian Williams , Persephone Borrow , Benjamin M. Chain , Clare Jolly

A simple deterministic model is proposed to represent the basic aspects concerning the effects of different antiretroviral treatment schedules on HIV incidence and prevalence of affected populations. The model mimics current treatment…

Populations and Evolution · Quantitative Biology 2009-09-29 L. F. Lopez , F. A. B. Coutinho , M. N. Burattini , E. Massad

Cell heterogeneity plays an important role in patient responses to drug treatments. In many cancers, it is associated with poor treatment outcomes. Many modern drug combination therapies aim to exploit cell heterogeneity, but determining…

Quantitative Methods · Quantitative Biology 2025-02-18 Simon F. Martina-Perez , Samuel W. S. Johnson , Rebecca M. Crossley , Jennifer C. Kasemeier , Paul M. Kulesa , Ruth E. Baker

This paper considers the optimal control for hybrid systems whose trajectories transition between distinct subsystems when state-dependent constraints are satisfied. Though this class of systems is useful while modeling a variety of…

Optimization and Control · Mathematics 2018-03-21 Pengcheng Zhao , Shankar Mohan , Ram Vasudevan

We study the optimal control problem of maximizing the spread of an information epidemic on a social network. Information propagation is modeled as a Susceptible-Infected (SI) process and the campaign budget is fixed. Direct recruitment and…

Social and Information Networks · Computer Science 2016-02-16 Kundan Kandhway , Joy Kuri

Modelling epidemics via classical population-based models suffers from shortcomings that so-called individual-based models are able to overcome, as they are able to take heterogeneity features into account, such as super-spreaders, and…

Optimization and Control · Mathematics 2022-05-16 C. Courtès , E. Franck , K. Lutz , L. Navoret , Y. Privat

This contribution mainly focuses on the finite horizon optimal control problems of a susceptible-infected-vaccinated(SIV) epidemic system governed by reaction-diffusion equations and Markov switching. Stochastic dynamic programming is…

Optimization and Control · Mathematics 2024-01-23 Zong Wang

We study the optimal control problem of allocating campaigning resources over the campaign duration and degree classes in a social network. Information diffusion is modeled as a Susceptible-Infected epidemic and direct recruitment of…

Social and Information Networks · Computer Science 2016-10-27 Kundan Kandhway , Joy Kuri

A distributed optimal control problem for a phase field system which physical context is that of tumor growth is discussed. The system we are going to take into account consists of a Cahn-Hilliard equation for the phase variable (relative…

Analysis of PDEs · Mathematics 2021-01-20 Andrea Signori

In this paper, the mathematical model of HIV infection for CD8+ T-cells is illustrated. The homotopy analysis method and the Laplace transformations are combined for solving this model. Also, the convergence theorem is proved to demonstrate…

Computational Engineering, Finance, and Science · Computer Science 2019-07-03 Samad Noeiaghdam , Emran Khoshrouye Ghiasi

This paper considers the problem of designing time-dependent, real-time control policies for controllable nonlinear diffusion processes, with the goal of obtaining maximally-informative observations about parameters of interest. More…

Methodology · Statistics 2014-10-16 Giles Hooker , Kevin K. Lin , Bruce Rogers

Recent wide spreading of Ransomware has created new challenges for cybersecurity over large-scale networks. The densely connected networks can exacerbate the spreading and makes the containment and control of the malware more challenging.…

Systems and Control · Computer Science 2018-10-12 Vladislav Taynitskiy , Elena Gubar , Quanyan Zhu