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Randomly connected neural networks have long served as a theoretical tool for studying collective dynamics in neural populations, yet quantitative comparisons to experiments remain limited. Recent technological advances have made it…

Neurons and Cognition · Quantitative Biology 2026-05-27 Zehui Zhao , Michael J Pasek , Ilya M Nemenman

Cells use genetic switches to shift between alternate stable gene expression states, e.g., to adapt to new environments or to follow a developmental pathway. Conceptually, these stable phenotypes can be considered as attractive states on an…

Molecular Networks · Quantitative Biology 2021-06-18 Michael Assaf , Shay Be'er , Elijah Roberts

To celebrate Hans Frauenfelder's achievements, we examine energy(-like) "landscapes" for complex living systems. Energy landscapes summarize all possible dynamics of some physical systems. Energy(-like) landscapes can explain some…

Quantitative Methods · Quantitative Biology 2021-10-18 Lars Koopmans , Hyun Youk

This thesis is a compendium of research which brings together ideas from the fields of Complex Networks and Computational Neuroscience to address two questions regarding neural systems: 1) How the activity of neurons, via synaptic changes,…

Neurons and Cognition · Quantitative Biology 2013-02-19 Samuel Johnson

We use energy landscape methods to investigate the response of a supercooled liquid to random pinning. We classify the structural similarity of different energy minima using a measure of overlap. This analysis reveals a correspondence…

Statistical Mechanics · Physics 2019-01-18 S. P. Niblett , V. K. de Souza , R. L. Jack , D. J Wales

Networks are ubiquitous throughout science and engineering. A number of methods, including some from our own group, have explored how one goes about computing or predicting the dynamics of networks given information about internal models of…

Molecular Networks · Quantitative Biology 2017-11-06 Gabriel A. Silva

Scale-free and non-computable characteristics of natural networks are found to result from the least-time dispersal of energy. To consider a network as a thermodynamic system is motivated since ultimately everything that exists can be…

General Physics · Physics 2011-06-22 Tuomo Hartonen , Arto Annila

Adaptation to changing environments is a universal feature of life and can involve the organism modifying itself in response to the environment as well as actively modifying the environment to control selection pressures. The latter case…

Populations and Evolution · Quantitative Biology 2023-01-10 Edward D. Lee , Jessica C. Flack , David C. Krakauer

We describe a numerical study of the potential energy landscape for the two-dimensional XY model (with no disorder), considering up to 100 spins and CPU and GPU implementations of local optimization, focusing on minima and saddles of index…

Statistical Mechanics · Physics 2013-11-27 Dhagash Mehta , Ciaran Hughes , Mario Schröck , David J. Wales

We consider recent reports on small-world topologies of interaction networks derived from the dynamics of spatially extended systems that are investigated in diverse scientific fields such as neurosciences, geophysics, or meteorology. With…

Data Analysis, Statistics and Probability · Physics 2011-05-12 Stephan Bialonski , Marie-Therese Horstmann , Klaus Lehnertz

Biological networks such as gene regulatory networks possess desirable properties. They are more robust and controllable than random networks. This motivates the search for structural and dynamical features that evolution has incorporated…

Molecular Networks · Quantitative Biology 2024-02-16 Claus Kadelka , David Murrugarra

Energy landscapes are high-dimensional surfaces representing the dependence of system energy on variable configurations, which determine crucially the system's emergent behavior but are difficult to be analyzed due to their high-dimensional…

Disordered Systems and Neural Networks · Physics 2024-05-24 Ho Fai Po , Chi Ho Yeung

Neural networks can emulate nonlinear physical systems with high accuracy, yet they may produce physically-inconsistent results when violating fundamental constraints. Here, we introduce a systematic way of enforcing nonlinear analytic…

Computational Physics · Physics 2021-03-10 Tom Beucler , Michael Pritchard , Stephan Rasp , Jordan Ott , Pierre Baldi , Pierre Gentine

The neocortex, a complex system driving multi-region interactions, remains a core puzzle in neuroscience. Despite quantitative insights across brain scales, understanding the mechanisms underlying neural activities is challenging. Advances…

Neurons and Cognition · Quantitative Biology 2024-11-27 Xiaochen Wang , Yuxuan Wu , Feng Zhang , Jin Wang

Characterizing the loss of a neural network with respect to model parameters, i.e., the loss landscape, can provide valuable insights into properties of that model. Various methods for visualizing loss landscapes have been proposed, but…

There are many surprising and perhaps counter-intuitive properties of optimization of deep neural networks. We propose and experimentally verify a unified phenomenological model of the loss landscape that incorporates many of them. High…

Machine Learning · Computer Science 2019-06-12 Stanislav Fort , Stanislaw Jastrzebski

Because of the global need to increase power production from renewable energy resources, developments in the online monitoring of the associated infrastructure is of interest to reduce operation and maintenance costs. However, challenges…

Machine Learning · Computer Science 2025-10-29 Simon M. Brealy , Lawrence A. Bull , Pauline Beltrando , Anders Sommer , Nikolaos Dervilis , Keith Worden

Predicting how the brain can be driven to specific states by means of internal or external control requires a fundamental understanding of the relationship between neural connectivity and activity. Network control theory is a powerful tool…

Neurons and Cognition · Quantitative Biology 2019-08-12 Teresa M. Karrer , Jason Z. Kim , Jennifer Stiso , Ari E. Kahn , Fabio Pasqualetti , Ute Habel , Danielle S. Bassett

Existing adaptive bias techniques, which seek to estimate free energies and physical properties from molecular simulations, are limited by their reliance on fixed kernels or basis sets which hinder their ability to efficiently conform to…

Statistical Mechanics · Physics 2018-04-04 Hythem Sidky , Jonathan K. Whitmer

Living systems are hierarchical control systems that display a small world network structure, in which many smaller clusters are nested within fewer larger ones, producing a fractal-like structure with a power-law cluster size distribution…

Neurons and Cognition · Quantitative Biology 2023-06-22 Rutger Goekoop , Roy de Kleijn
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