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Predicting drug side-effects before they occur is a key task in keeping the number of drug-related hospitalizations low and to improve drug discovery processes. Automatic predictors of side-effects generally are not able to process the…

Machine Learning · Statistics 2022-12-01 Pietro Bongini , Elisa Messori , Niccolò Pancino , Monica Bianchini

With the advanced imaging technology, digital pathology imaging of tumor tissue slides is becoming a routine clinical procedure for cancer diagnosis. This process produces massive imaging data that capture histological details in high…

Applications · Statistics 2020-12-10 Esteban Fernández Morales , Cong Zhang , Guanghua Xiao , Chul Moon , Qiwei Li

Predicting cancer dynamics under treatment is challenging due to high inter-patient heterogeneity, lack of predictive biomarkers, and sparse and noisy longitudinal data. Mathematical models can summarize cancer dynamics by a few…

Quantitative Methods · Quantitative Biology 2024-05-24 Even Moa Myklebust , Arnoldo Frigessi , Fredrik Schjesvold , Jasmine Foo , Kevin Leder , Alvaro Köhn-Luque

Emerging research has highlighted that artificial intelligence-based multimodal fusion of digital pathology and transcriptomic features can improve cancer diagnosis (grading/subtyping) and prognosis (survival risk) prediction. However, such…

Computer Vision and Pattern Recognition · Computer Science 2026-01-14 Samiran Dey , Christopher R. S. Banerji , Partha Basuchowdhuri , Sanjoy K. Saha , Deepak Parashar , Tapabrata Chakraborti

Melanoma is a type of cancer that begins in the cells controlling the pigment of the skin, and it is often referred to as the most dangerous skin cancer. Diagnosing melanoma can be time-consuming, and a recent increase in melanoma incidents…

Image and Video Processing · Electrical Eng. & Systems 2023-12-15 Marie Bø-Sande , Edvin Benjaminsen , Neel Kanwal , Saul Fuster , Helga Hardardottir , Ingrid Lundal , Emiel A. M. Janssen , Kjersti Engan

The accurate prognosis of Glioblastoma Multiforme (GBM) plays an essential role in planning correlated surgeries and treatments. The conventional models of survival prediction rely on radiomic features using magnetic resonance imaging…

Image and Video Processing · Electrical Eng. & Systems 2021-05-03 Mobarakol Islam , Navodini Wijethilake , Hongliang Ren

Segmentation of brain tumor from magnetic resonance imaging (MRI) is a vital process to improve diagnosis, treatment planning and to study the difference between subjects with tumor and healthy subjects. In this paper, we exploit a…

Image and Video Processing · Electrical Eng. & Systems 2021-04-05 Mobarakol Islam , V Jeya Maria Jose , Hongliang Ren

Semi-supervised learning (SSL) has made notable advancements in medical image segmentation (MIS), particularly in scenarios with limited labeled data and significantly enhancing data utilization efficiency. Previous methods primarily focus…

Computer Vision and Pattern Recognition · Computer Science 2024-11-25 Mengzhu Wang , Jiao Li , Houcheng Su , Nan Yin , Liang Yang , Shen Li

A key challenge for machine intelligence is to learn new visual concepts without forgetting the previously acquired knowledge. Continual learning is aimed towards addressing this challenge. However, there is a gap between existing…

Machine Learning · Computer Science 2024-02-01 Yan Luo , Yongkang Wong , Mohan Kankanhalli , Qi Zhao

The development of computational pathology lies in the consensus that pathological characteristics of tumors are significant guidance for cancer diagnostics. Most existing research focuses on the inner-contextual information within each WSI…

Computer Vision and Pattern Recognition · Computer Science 2024-10-15 Jun Shi , Tong Shu , Zhiguo Jiang , Wei Wang , Haibo Wu , Yushan Zheng

We consider the general problem of utilizing both labeled and unlabeled data to improve data representation performance. A new semi-supervised learning framework is proposed by combing manifold regularization and data representation methods…

Machine Learning · Computer Science 2015-02-16 Weiya Ren

It is increasingly common clinically for cancer specimens to be examined using techniques that identify somatic mutations. In principle these mutational profiles can be used to diagnose the tissue of origin, a critical task for the 3-5% of…

Methodology · Statistics 2020-07-14 Saptarshi Chakraborty , Colin B. Begg , Ronglai Shen

In the field of lung cancer research, particularly in the analysis of overall survival (OS), artificial intelligence (AI) serves crucial roles with specific aims. Given the prevalent issue of missing data in the medical domain, our primary…

Machine Learning · Computer Science 2026-03-13 Camillo Maria Caruso , Valerio Guarrasi , Sara Ramella , Paolo Soda

Variable selection is crucial in high-dimensional omics-based analyses, since it is biologically reasonable to assume only a subset of non-noisy features contributes to the data structures. However, the task is particularly hard in an…

Methodology · Statistics 2022-03-22 Emilie Eliseussen , Thomas Fleischer , Valeria Vitelli

We present a methodology for using unlabeled data to design semi-supervised learning (SSL) methods that improve the predictive performance of supervised learning for regression tasks. The main idea is to design different mechanisms for…

Methodology · Statistics 2025-11-18 Oren Yuval , Saharon Rosset

Accurate and robust cell nuclei classification is the cornerstone for a wider range of tasks in digital and Computational Pathology. However, most machine learning systems require extensive labeling from expert pathologists for each…

Quantitative Methods · Quantitative Biology 2016-12-05 Stefan Bauer , Nicolas Carion , Peter Schüffler , Thomas Fuchs , Peter Wild , Joachim M. Buhmann

Addressing the critical need for accurate prognostic biomarkers in cancer treatment, quantifying tumor-infiltrating lymphocytes (TILs) in non-small cell lung cancer (NSCLC) presents considerable challenges. Manual TIL quantification in…

Computer Vision and Pattern Recognition · Computer Science 2025-12-02 Nikita Shvetsov , Anders Sildnes , Masoud Tafavvoghi , Lill-Tove Rasmussen Busund , Stig Dalen , Kajsa Møllersen , Lars Ailo Bongo , Thomas K. Kilvaer

Medical image segmentation is a fundamental and critical step in many clinical approaches. Semi-supervised learning has been widely applied to medical image segmentation tasks since it alleviates the heavy burden of acquiring…

Image and Video Processing · Electrical Eng. & Systems 2022-08-29 Yichi Zhang , Rushi Jiao , Qingcheng Liao , Dongyang Li , Jicong Zhang

Integrating the different data modalities of cancer patients can significantly improve the predictive performance of patient survival. However, most existing methods ignore the simultaneous utilization of rich semantic features at different…

Computer Vision and Pattern Recognition · Computer Science 2024-05-14 Liangrui Pan , Yijun Peng , Yan Li , Yiyi Liang , Liwen Xu , Qingchun Liang , Shaoliang Peng

Semi-supervised multi-organ medical image segmentation aids physicians in improving disease diagnosis and treatment planning and reduces the time and effort required for organ annotation.Existing state-of-the-art methods train the labeled…

Computer Vision and Pattern Recognition · Computer Science 2024-09-04 Haochen Zhao , Hui Meng , Deqian Yang , Xiaozheng Xie , Xiaoze Wu , Qingfeng Li , Jianwei Niu
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