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High biocompatibility, variable size ranging from ~ 5 nm, stable luminescence from its color centers and simple carbon chemistry for biomolecule grafting make nanodiamond (ND) particles an attractive alternative to molecular dyes for…

Fluorescent nanodiamonds (FNDs) hosting nitrogen-vacancy (NV) centers have attracted considerable attention for quantum sensing applications, particularly owing to notable advancements achieved in the field of weak magnetic signal detection…

Magnetometry using Nitrogen-Vacancy (NV) color centers in diamond predominantly relies on microwave spectroscopy. However, microwaves may hinder certain studies involving biological systems or thin conductive samples. This work demonstrates…

Probing electrical and magnetic properties in aqueous environments remains a frontier challenge in nanoscale sensing. Our inability to do so with quantitative accuracy imposes severe limitations, for example, on our understanding of the…

Magnetic Resonance Imaging (MRI) can characterize and discriminate among tissues using their diverse physical and biochemical properties. Unfortunately, submicrometer screening of biological specimens is presently not possible, mainly due…

Mesoscale and Nanoscale Physics · Physics 2010-11-03 C. A. Meriles , L. Jiang , G. Goldstein , J. S. Hodges , J. R. Maze , M. D. Lukin , P. Cappellaro

Scanning probe microscopy is one of the most versatile windows into the nanoworld, providing imaging access to a variety of sample properties, depending on the probe employed. Tunneling probes map electronic properties of samples, magnetic…

Mesoscale and Nanoscale Physics · Physics 2015-01-09 Thomas Häberle , Dominik Schmid-Lorch , Friedemann Reinhard , Jörg Wrachtrup

Super-resolution imaging techniques enable nanoscale microscopy in fields such as physics, biology, and chemistry. However, many super-resolution techniques require specialized optical components, such as a helical-phase mask. We present a…

High-Q optical resonators allow label-free detection of individual nanoparticles through perturbation of optical signatures but have practical limitations due to reliance on random diffusion to deliver particles to the sensing region. We…

Optics · Physics 2016-10-03 Jeewon Suh , Kewen Han , Christopher W Peterson , Gaurav Bahl

Diamond nanoparticles (nanodiamonds) can transport active drugs in cultured cells as well as in vivo. However, in the latter case, methods allowing to determine their bioavailability accurately are still lacking. Nanodiamond can be made…

Ion implantation is used to create magnetic ion embedded nanodiamonds for use in a wide range of biological and medical applications; however, the effectiveness of this process depends heavily on separating magnetic nanodiamonds from…

Paramagnetic magnetic resonance, a powerful technique for characterizing and identifying chemical targets, is increasingly used for imaging; however, low spin polarization at room temperature and moderate magnetic fields poses challenges…

Mesoscale and Nanoscale Physics · Physics 2019-09-04 C. M. Purser , V. P. Bhallamudi , C. S. Wolfe , H. Yusuf , B. A. McCullian , C. Jayaprakash , M. E. Flatté , P. C. Hammel

Sensing based on Nitrogen-Vacancy (NV) centers in nanodiamonds (NDs) offers significant potential across various applications. However, optimizing their quantum-optical properties remains challenging. This study focuses on enhancing and…

In this work we use fluorescence from nitrogen-vacancy defects in diamond to detect and explore other paramagnetic defects in the diamond, such as P1 defects, which are commonly undetectable through optical detection of magnetic resonance…

Quantum Physics · Physics 2019-07-03 Nir Alfasi , Sergei Masis , Oleg Shtempluck , Eyal Buks

We have investigated the unique effects of metallic nanoparticle on the ring resonator, especially multiple Au nanoparticles on the micro ring resonator with the 4-port configuration on chip. For the Au nanoparticle, because it has smaller…

Optics · Physics 2010-08-03 Ali Haddadpour , Yasha Yi

Nitrogen vacancy (NV) color centers in diamond are a leading modality for both superresolution optical imaging and nanoscale magnetic field sensing. In this work, we solve the remaining key challenge of performing optical magnetic imaging…

The rapid decay of target signal strength with distance from the sensor presents a key challenge in nanoscale magnetic sensing with nitrogen-vacancy (NV) centers in diamond, limiting both sensitivity and spatial resolution. Here we…

Nuclear magnetic resonance (NMR) spectroscopy is a widely used tool for chemical analysis and molecular structure identification. Because it typically relies on the weak magnetic fields produced by a small thermal nuclear spin polarization,…

Applied Physics · Physics 2020-06-11 Dominik B. Bucher , David R. Glenn , Hongkun Park , Mikhail D. Lukin , Ronald L. Walsworth

Magnetic resonance imaging (MRI) is a non-invasive and label-free technique widely used in medical diagnosis and life science research, and its success has benefited greatly from continuing efforts on enhancing contrast and resolution. Here…

Transmission electron microscopy (TEM) can be used to successfully determine the structures of proteins. However, such studies are typically done ex situ after extraction of the protein from the cellular environment. Here we describe an…

Biological Physics · Physics 2017-11-07 Michael P. Lake , Louis-S. Bouchard

We demonstrate a magnetometry technique using nitrogen-vacancy centres in diamond which makes use of coherent two-photon transitions. We find that the sensitivity to magnetic fields can be significantly improved in isotopically purified…

Quantum Physics · Physics 2015-09-08 A. Angerer , T. Nöbauer , G. Wachter , M. Markham , A. Stacey , J. Majer , J. Schmiedmayer , M. Trupke