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Active forces occurring within cells can drive crucial biological processes that involve spontaneous organization and shape change, such as cell division. Motivated by recent in vitro experiments of nematic droplets of cytoskeletal…

Soft Condensed Matter · Physics 2021-02-16 Fabian Jan Schwarzendahl , Pierre Ronceray , Kimberly L. Weirich , Kinjal Dasbiswas

We use molecular dynamics to study the ordering of a nematic liquid crystal around a spherical particle or droplet. Homeotropic boundary conditions and strong anchoring create a hedgehog director configuration on the particle surface and in…

Soft Condensed Matter · Physics 2013-03-19 D. Andrienko , G. Germano , M. P. Allen

Microbullet particles, cylinders with one blunt and one spherical end, offer a novel platform to study the effects of anisotropy and curvature on colloidal assembly in complex fluids. Here, we disperse microbullets in…

Linear defects such as dislocations and disclinations in ordered materials attract foreign particles since they replace strong elastic distortions at the defect cores. In this work, we explore the behavior of isotropic droplets nucleating…

How epithelial cells coordinate their polarity to form functional tissues is an open question in cell biology. Here, we characterize a unique type of polarity found in liver tissue, nematic cell polarity, which is different from vectorial…

Using computer simulations we investigate the microscopic structure of the singular director field within a nematic droplet. As a theoretical model for nematic liquid crystals we take hard spherocylinders. To induce an overall topological…

Soft Condensed Matter · Physics 2009-10-31 J. Dzubiella , M. Schmidt , H. Loewen

The study of spindle-like cells as nematic liquid crystals has led to remarkable insights in the understanding of tissue organization and morphogenesis. In the characterization of this anomalous liquid crystal material, we focus on the…

Soft Condensed Matter · Physics 2025-07-24 Aniruddh Murali , Prasoon Awasthi , Kirsten Endresen , Arkadiusz Goszczak , Francesca Serra

Directed growth, anisotropic cell shapes, and confinement drive self-organization in multicellular systems. We investigate the influence of particle shape on the distribution and dynamics of nematic microdomains in a minimal in-silico model…

Soft Condensed Matter · Physics 2025-12-03 Jonas Isensee , Philip Bittihn

The bipolar organization of the microtubule-based mitotic spindle is essential for the faithful segregation of chromosomes in cell division. Despite our extensive knowledge of genes and proteins, the physical mechanism of how the ensemble…

Biological Physics · Physics 2022-11-02 Lucan Yan , Tatsuya Fukuyama , Megumi Yamaoka , Yusuke T. Maeda , Yuta Shimamoto

The translation and shape deformations of a passive viscous Newtonian droplet immersed in an active nematic liquid crystal under circular confinement are analyzed using a linear stability analysis. We focus on the case of a sharply aligned…

Soft Condensed Matter · Physics 2025-07-29 Tanumoy Dhar , Michael J. Shelley , David Saintillan

We investigate the mechanics of an active droplet endowed with internal nematic order and surrounded by an isotropic Newtonian fluid. Using numerical simulations we demonstrate that, due to the interplay between the active stresses and the…

Soft Condensed Matter · Physics 2014-04-23 L. Giomi , A. DeSimone

In culture migrating and interacting amoeboid cells can form nematic liquid crystal phases. A polar nematic liquid crystal is formed if the interaction has a polar symmetry. One type of white blood cells (granulocytes) form clusters where…

Biological Physics · Physics 2007-05-23 Ralf Kemkemer , Dieter Kling , Dieter Kaufmann , Hans Gruler

There is now growing evidence of the emergence and biological functionality of liquid crystal features, including nematic order and topological defects, in cellular tissues. However, how such features that intrinsically rely on particle…

Soft Condensed Matter · Physics 2019-02-06 Romain Mueller , Julia Yeomans , Amin Doostmohammadi

The ability to manipulate polar entities with multiple external fields opens exciting possibilities for emerging functionalities and novel applications in spin systems, photonics, metamaterials, and soft matter. Liquid crystals (LCs),…

We study the phase ordering colloids suspended in a thermotropic nematic liquid crystal below the clearing point Tni and the resulting aggregated structure. Small (150nm) PMMA particles are dispersed in a classical liquid crystal matrix,…

Soft Condensed Matter · Physics 2007-05-23 V. J. Anderson , E. M. Terentjev , S. P. Meeker , J. Crain , W. C. K. Poon

A two-dimensional or quasi-two-dimensional nematic liquid crystal refers to a surface confined system. When such a system is further confined by external line boundaries or excluded from internal line boundaries, the nematic directors form…

Soft Condensed Matter · Physics 2022-04-27 Xiaomei Yao , Lei Zhang , Jeff Z. Y. Chen

We study spreading dynamics of nematic liquid crystal droplets within the framework of the long-wave approximation. A fourth order nonlinear parabolic partial differential equation governing the free surface evolution is derived. The…

Fluid Dynamics · Physics 2013-07-19 Te-Sheng Lin , Lou Kondic , Uwe Thiele , Linda J. Cummings

Confluent populations of elongated cells give rise to ordered patterns seen in nematic phase liquid crystals. We correlate cell elongation and intercellular distance with intercellular alignment using an amorphous spin glass model. We…

Biological Physics · Physics 2016-11-28 Sunil Pai , Nathan Loewke , Morgaine Green , Christine Cordeiro , Elise Cabral , Bertha Chen , Thomas Baer

The alignment of fibers and cells in living tissues affect their mechanical properties and functionality. In this context, one can draw an analogy between tissues and nematic liquid crystal elastomers. We explore this analogy by growing…

Soft Condensed Matter · Physics 2025-10-08 Kirsten Endresen , Aniruddh Murali , Birte Geerds , Daniel J. G. Pearce , Francesca Serra

Droplet formation has emerged as an essential concept for the spatiotemporal organisation of biomolecules in cells. However, classical descriptions of droplet dynamics based on passive liquid-liquid phase separation cannot capture the…

Biological Physics · Physics 2025-11-14 David Zwicker , Oliver W. Paulin , Cathelijne ter Burg
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