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We develop a framework for derivative Gaussian process latent variable models (DGP-LVMs) that can handle multi-dimensional output data using modified derivative covariance functions. The modifications account for complexities in the…

Methodology · Statistics 2025-06-10 Soham Mukherjee , Manfred Claassen , Paul-Christian Bürkner

Deep neural networks (DNN) have been used successfully in many scientific problems for their high prediction accuracy, but their application to genetic studies remains challenging due to their poor interpretability. In this paper, we…

Machine Learning · Computer Science 2021-10-01 Peyman H. Kassani , Fred Lu , Yann Le Guen , Zihuai He

Over the last decade, the process of automatic image colorization has been of significant interest for several application areas including restoration of aged or degraded images. This problem is highly ill-posed due to the large degrees of…

Computer Vision and Pattern Recognition · Computer Science 2018-07-16 Kamyar Nazeri , Eric Ng , Mehran Ebrahimi

Deep generative models (DGM) are neural networks with many hidden layers trained to approximate complicated, high-dimensional probability distributions using a large number of samples. When trained successfully, we can use the DGMs to…

Machine Learning · Computer Science 2021-04-13 Lars Ruthotto , Eldad Haber

Program synthesis is the process of generating a computer program following a set of specifications, which can be a high-level description of the problem and/or a set of input-output examples. The synthesis can be modeled as a search…

Neural and Evolutionary Computing · Computer Science 2023-04-07 Matheus Campos Fernandes , Fabrício Olivetti de França , Emilio Francesquini

Gaussian processes (GPs) can provide a principled approach to uncertainty quantification with easy-to-interpret kernel hyperparameters, such as the lengthscale, which controls the correlation distance of function values. However, selecting…

A recent line of research has exploited pre-trained generative diffusion models as priors for solving Bayesian inverse problems. We contribute to this research direction by designing a sequential Monte Carlo method for linear-Gaussian…

Machine Learning · Computer Science 2025-10-13 Filip Ekström Kelvinius , Zheng Zhao , Fredrik Lindsten

Deep generative models for graphs have exhibited promising performance in ever-increasing domains such as design of molecules (i.e, graph of atoms) and structure prediction of proteins (i.e., graph of amino acids). Existing work typically…

Machine Learning · Computer Science 2021-01-21 Wenbin Zhang , Liming Zhang , Dieter Pfoser , Liang Zhao

Many statistical problems involve optimization over a discrete parameter space having an unknown dimension. In such settings, gradient-based methods often fail due to the non-differentiability of the objective function or a non-convex or…

Applications · Statistics 2026-03-19 Mo Li , QiQi Lu , Robert Lund , Xueheng Shi

Majority of state-of-the-art deep learning methods are discriminative approaches, which model the conditional distribution of labels given inputs features. The success of such approaches heavily depends on high-quality labeled instances,…

Machine Learning · Computer Science 2019-09-13 Yanwu Xu , Mingming Gong , Junxiang Chen , Tongliang Liu , Kun Zhang , Kayhan Batmanghelich

Automatic programming, the task of generating computer programs compliant with a specification without a human developer, is usually tackled either via genetic programming methods based on mutation and recombination of programs, or via…

Artificial Intelligence · Computer Science 2021-02-09 Vadim Liventsev , Aki Härmä , Milan Petković

We propose a novel method for automatic program synthesis. P-Tree Programming represents the program search space through a single probabilistic prototype tree. From this prototype tree we form program instances which we evaluate on a given…

Artificial Intelligence · Computer Science 2017-07-13 Christian Oesch

Gaussian processes (GPs) have gained popularity as flexible machine learning models for regression and function approximation with an in-built method for uncertainty quantification. However, GPs suffer when the amount of training data is…

Machine Learning · Statistics 2025-11-26 Jonas Latz , Aretha L. Teckentrup , Simon Urbainczyk

The increasing availability of high-dimensional, longitudinal measures of gene expression can facilitate understanding of biological mechanisms, as required for precision medicine. Biological knowledge suggests that it may be best to…

Applications · Statistics 2025-04-18 Jiachen Cai , Robert J. B. Goudie , Colin Starr , Brian D. M. Tom

High-dimensional PDEs have been a longstanding computational challenge. We propose to solve high-dimensional PDEs by approximating the solution with a deep neural network which is trained to satisfy the differential operator, initial…

Mathematical Finance · Quantitative Finance 2018-10-17 Justin Sirignano , Konstantinos Spiliopoulos

Guarded recursion is a framework allowing for a formalisation of streams in classical programming languages. The latter take their semantics in cartesian closed categories. However, some programming paradigms do not take their semantics in…

Logic in Computer Science · Computer Science 2025-03-05 Louis Lemonnier

We introduce Deep Jump Gaussian Processes (DJGP), a novel method for surrogate modeling of a piecewise continuous function on a high-dimensional domain. DJGP addresses the limitations of conventional Jump Gaussian Processes (JGP) in…

Machine Learning · Computer Science 2026-01-16 Yang Xu , Chiwoo Park

In recent years, deep learning methods applying unsupervised learning to train deep layers of neural networks have achieved remarkable results in numerous fields. In the past, many genetic algorithms based methods have been successfully…

Neural and Evolutionary Computing · Computer Science 2017-11-22 Eli David , Iddo Greental

One of the focus areas of modern scientific research is to reveal mysteries related to genes and their interactions. The dynamic interactions between genes can be encoded into a gene regulatory network (GRN), which can be used to gain…

Optimization and Control · Mathematics 2020-07-16 Atte Aalto , Lauri Viitasaari , Pauliina Ilmonen , Laurent Mombaerts , Jorge Goncalves

With the growth of machine learning algorithms with geometry primitives, a high-efficiency library with differentiable geometric operators are desired. We present an optimized Differentiable Geometry Algorithm Library (DGAL) loaded with…

Computational Geometry · Computer Science 2020-11-24 Yuanxin Zhong