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Scientific applications often contain large, computationally-intensive, and irregular parallel loops or tasks that exhibit stochastic characteristics. Applications may suffer from load imbalance during their execution on high-performance…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-10-16 Ali Mohammed , Ahmed Eleliemy , Florina M. Ciorba , Franziska Kasielke , Ioana Banicescu

This paper presents the first demonstration of a viable, ultra-fast, radiation-hard machine learning (ML) application on FPGAs, which could be used in future high-energy physics experiments. We present a three-fold contribution, with the…

The challenges associated with effectively programming FPGAs have been a major blocker in popularising reconfigurable architectures for HPC workloads. However new compiler technologies, such as MLIR, are providing new capabilities which…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-10-04 Gabriel Rodriguez-Canal , Nick Brown , Maurice Jamieson , Emilien Bauer , Anton Lydike , Tobias Grosser

Modern data-intensive applications demand high computation capabilities with strict power constraints. Unfortunately, such applications suffer from a significant waste of both execution cycles and energy in current computing systems due to…

Hardware Architecture · Computer Science 2021-07-06 Gagandeep Singh , Mohammed Alser , Damla Senol Cali , Dionysios Diamantopoulos , Juan Gómez-Luna , Henk Corporaal , Onur Mutlu

We present a GPU implementation of LAMMPS, a widely-used parallel molecular dynamics (MD) software package, and show 5x to 13x single node speedups versus the CPU-only version of LAMMPS. This new CUDA package for LAMMPS also enables…

Materials Science · Physics 2011-03-08 Christian R. Trott , Lars Winterfeld , Paul S. Crozier

Molecular dynamics (MD) has become a powerful tool for studying biophysical systems, due to increasing computational power and availability of software. Although MD has made many contributions to better understanding these complex…

Computational Physics · Physics 2019-09-27 Yihang Wang , Joao Marcelo Lamim Ribeiro , Pratyush Tiwary

Deep learning (DL) has emerged as a rapidly developing advanced technology, enabling the performance of complex tasks involving image recognition, natural language processing, and autonomous decision-making with high levels of accuracy.…

Hardware Architecture · Computer Science 2026-03-11 Soumita Chatterjee , Sudip Ghosh , Tamal Ghosh , Hafizur Rahaman

The process of setting up and successfully running Molecular Dynamics Simulations (MDS) is outlined to be incredibly labour and computationally expensive with a very high barrier to entry for newcomers wishing to utilise the benefits and…

Computational Engineering, Finance, and Science · Computer Science 2025-03-17 Jai Geddes Nelson , Xiaochen Liu , Ken Tye Yong

Modern graphics processing units (GPUs) provide impressive computing resources, which can be accessed conveniently through the CUDA programming interface. We describe how GPUs can be used to considerably speed up molecular dynamics (MD)…

Computational Physics · Physics 2011-04-08 Peter H. Colberg , Felix Höfling

In this paper, we describe the algorithms we implemented in FDPS to make efficient use of accelerator hardware such as GPGPUs. We have developed FDPS to make it possible for many researchers to develop their own high-performance parallel…

Instrumentation and Methods for Astrophysics · Physics 2020-02-12 Masaki Iwasawa , Daisuke Namekata , Keigo Nitadori , Kentaro Nomura , Long Wang , Miyuki Tsubouchi , Junichiro Makino

This book focuses on the use of algorithmic high-level synthesis (HLS) to build application-specific FPGA systems. Our goal is to give the reader an appreciation of the process of creating an optimized hardware design using HLS. Although…

Hardware Architecture · Computer Science 2018-05-11 Ryan Kastner , Janarbek Matai , Stephen Neuendorffer

Although high-level synthesis (HLS) tools have significantly improved programmer productivity over hardware description languages, developing for FPGAs remains tedious and error prone. Programmers must learn and implement a large set of…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-12-29 Johannes de Fine Licht , Tiziano De Matteis , Tal Ben-Nun , Andreas Kuster , Oliver Rausch , Manuel Burger , Carl-Johannes Johnsen , Torsten Hoefler

In recent years, domain-specific accelerators (DSAs) have gained popularity for applications such as deep learning and autonomous driving. To facilitate DSA designs, programmers use high-level synthesis (HLS) to compile a high-level…

Machine Learning · Computer Science 2024-07-19 Zongyue Qin , Yunsheng Bai , Atefeh Sohrabizadeh , Zijian Ding , Ziniu Hu , Yizhou Sun , Jason Cong

Customized accelerators have revolutionized modern computing by delivering substantial gains in energy efficiency and performance through hardware specialization. Field-Programmable Gate Arrays (FPGAs) play a crucial role in this paradigm,…

Hardware Architecture · Computer Science 2025-09-25 Stéphane Pouget , Michael Lo , Louis-Noël Pouchet , Jason Cong

Recent advancements in large language models (LLMs) boasting billions of parameters have generated a significant demand for efficient deployment in inference workloads. The majority of existing approaches rely on temporal architectures that…

Machine Learning · Computer Science 2024-04-09 Hongzheng Chen , Jiahao Zhang , Yixiao Du , Shaojie Xiang , Zichao Yue , Niansong Zhang , Yaohui Cai , Zhiru Zhang

High-level synthesis (HLS) has enabled the rapid development of custom hardware circuits for many software applications. However, developing high-performance hardware circuits using HLS is still a non-trivial task requiring expertise in…

Hardware Architecture · Computer Science 2025-01-17 Suhail Basalama , Jason Cong

FPGAs offer high performance, low latency, and energy efficiency for accelerated computing, yet adoption in scientific and edge settings is limited by the specialized hardware expertise required. High-level synthesis (HLS) boosts…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-02-09 Maxim Moraru , Kamalavasan Kamalakkannan , Jered Dominguez-Trujillo , Patrick Diehl , Atanu Barai , Julien Loiseau , Zachary Kent Baker , Howard Pritchard , Galen M Shipman

Real time data acquisition systems in nuclear science often rely on high-speed logic designs to reach the fast data rate requirements. They are mostly coded in a hardware description language (HDL). However, in recent years, high level…

Instrumentation and Detectors · Physics 2018-06-29 Tétrault Marc-André

Molecular Dynamics (MD) simulations play a central role in physics-driven drug discovery. MD applications often use the Particle Mesh Ewald (PME) algorithm to accelerate electrostatic force computations, but efficient parallelization has…

Hardware Architecture · Computer Science 2021-04-06 Lawrence C. Stewart , Carlo Pascoe , Brian W. Sherman , Martin Herbordt , Vipin Sachdeva

Efficient implementations of the classical molecular dynamics (MD) method for Lennard-Jones particle systems are considered. Not only general algorithms but also techniques that are efficient for some specific CPU architectures are also…

Statistical Mechanics · Physics 2015-03-17 H. Watanabe , M. Suzuki , N. Ito