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This paper presents a deep reinforcement learning (DRL) framework for dynamic portfolio optimization under market uncertainty and risk. The proposed model integrates a Sharpe ratio-based reward function with direct risk control mechanisms,…

Portfolio Management · Quantitative Finance 2025-11-17 Emmanuel Lwele , Sabuni Emmanuel , Sitali Gabriel Sitali

Reinforcement learning has been increasingly applied in monitoring applications because of its ability to learn from previous experiences and can make adaptive decisions. However, existing machine learning-based health monitoring…

Machine Learning · Computer Science 2024-10-28 Thanveer Shaik , Xiaohui Tao , Lin Li , Haoran Xie , U R Acharya , Raj Gururajan , Xujuan Zhou

Multimodal models trained on complete modality data often exhibit a substantial decrease in performance when faced with imperfect data containing corruptions or missing modalities. To address this robustness challenge, prior methods have…

Multimedia · Computer Science 2023-10-24 Mengxi Chen , Jiangchao Yao , Linyu Xing , Yu Wang , Ya Zhang , Yanfeng Wang

In a sequential multiple-assignment randomized trial (SMART), a sequence of treatments is given to a patient over multiple stages. In each stage, randomization may be done to allocate patients to different treatment groups. Even though…

Methodology · Statistics 2024-01-09 Rik Ghosh , Bibhas Chakraborty , Inbal Nahum-Shani , Megan E. Patrick , Palash Ghosh

Individualized treatment rules/recommendations (ITRs) aim to improve patient outcomes by tailoring treatments to the characteristics of each individual. However, when there are many treatment groups, existing methods face significant…

Methodology · Statistics 2025-05-27 Ke Zhu , Jianing Chu , Ilya Lipkovich , Wenyu Ye , Shu Yang

Health policy decisions regarding patient treatment strategies require consideration of both treatment effectiveness and cost. Optimizing treatment rules with respect to effectiveness may result in prohibitively expensive strategies; on the…

Methodology · Statistics 2021-10-20 Nicholas Illenberger , Andrew J. Spieker , Nandita Mitra

This paper presents a shared-control rehabilitation policy for a custom 6-degree-of-freedom (6-DoF) upper-limb robot that decomposes complex reaching tasks into decoupled spatial axes. The patient governs the primary reaching direction…

Robotics · Computer Science 2026-03-09 Yaqi Li , Zhengqi Han , Huifang Liu , Steven W. Su

Ordinary differential equations (ODEs) provide a powerful framework for modeling dynamic systems arising in a wide range of scientific domains. However, most existing ODE methods focus on a single system, and do not adequately address the…

Methodology · Statistics 2026-04-08 Shuoxun Xu , Zijian Guo , Brooke R. Staveland , Robert T. Knight , Lexin Li

With the growing popularity of deep reinforcement learning (DRL), human-in-the-loop (HITL) approach has the potential to revolutionize the way we approach decision-making problems and create new opportunities for human-AI collaboration. In…

Enabling a high-degree-of-freedom robot to learn specific skills is a challenging task due to the complexity of robotic dynamics. Reinforcement learning (RL) has emerged as a promising solution; however, addressing such problems requires…

Robotics · Computer Science 2025-05-06 Changxin Huang , Junyang Liang , Yanbin Chang , Jingzhao Xu , Jianqiang Li

In this study, we propose a tailored DL framework for patient-specific performance that leverages the behavior of a model intentionally overfitted to a patient-specific training dataset augmented from the prior information available in an…

Machine Learning · Computer Science 2022-04-06 Jaehee Chun , Justin C. Park , Sven Olberg , You Zhang , Dan Nguyen , Jing Wang , Jin Sung Kim , Steve Jiang

Estimating optimal dynamic treatment regimes (DTRs) using observational data is often challenged by nonignorable missing covariates arsing from informative monitoring of patients in clinical practice. To address nonignorable missingness of…

Methodology · Statistics 2025-07-01 Jian Sun , Bo Fu , Li Su

A dynamic treatment regime is a sequence of decision rules in which each decision rule recommends treatment based on features of patient medical history such as past treatments and outcomes. Existing methods for estimating optimal dynamic…

Methodology · Statistics 2015-05-22 Kristin A. Linn , Eric B. Laber , Leonard A. Stefanski

Due to its excellent performance in rate and resolution, fully-digital (FD) massive multiple-input multiple-output (MIMO) antenna arrays has been widely applied in data transmission and direction of arrival (DOA) measurements, etc. But it…

Signal Processing · Electrical Eng. & Systems 2024-06-13 Jiatong Bai , Feng Shu , Qinghe Zheng , Bo Xu , Baihua Shi , Yiwen Chen , Weibin Zhang , Xianpeng Wang

Dynamic Treatment Regimes (DTRs) provide a systematic approach for making sequential treatment decisions that adapt to individual patient characteristics, particularly in clinical contexts where survival outcomes are of interest.…

Machine Learning · Computer Science 2025-03-11 Animesh Kumar Paul , Russell Greiner

Leveraging multimodal data, particularly the integration of whole-slide histology images (WSIs) and transcriptomic profiles, holds great promise for improving cancer survival prediction. However, excessive redundancy in multimodal data can…

Image and Video Processing · Electrical Eng. & Systems 2025-03-07 Hong Liu , Haosen Yang , Federica Eduati , Josien P. W. Pluim , Mitko Veta

In Amazon robotic warehouses, the destination-to-chute mapping problem is crucial for efficient package sorting. Often, however, this problem is complicated by uncertain and dynamic package induction rates, which can lead to increased…

Machine Learning · Computer Science 2025-03-14 Guangyi Liu , Suzan Iloglu , Michael Caldara , Joseph W. Durham , Michael M. Zavlanos

The recent interweaving of AI-6G technologies has sparked extensive research interest in further enhancing reliable and timely communications. \emph{Age of Information} (AoI), as a novel and integrated metric implying the intricate…

Information Theory · Computer Science 2023-04-18 Kunpeng Liu , Aimin Li , Shaohua Wu

The focus of precision medicine is on decision support, often in the form of dynamic treatment regimes (DTRs), which are sequences of decision rules. At each decision point, the decision rules determine the next treatment according to the…

Methodology · Statistics 2023-12-22 Cong Jiang , Mary Thompson , Michael Wallace

Dynamic treatment regimes (DTRs) are critical to precision medicine, optimizing long-term outcomes through personalized, real-time decision-making in evolving clinical contexts, but require careful supervision for unsafe treatment risks.…

Machine Learning · Computer Science 2025-06-10 Yishan Shen , Yuyang Ye , Hui Xiong , Yong Chen
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