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In this article, the feasibility of using optimal control theory will be studied to develop control theoretic methods for personalized treatment of HCV patients. The mathematical model for HCV progression includes compartments for healthy…

Optimization and Control · Mathematics 2023-09-07 Anh-Tuan Nguyen , Hien Tran

Models of spread processes over non-trivial networks are commonly motivated by modeling and analysis of biological networks, computer networks, and human contact networks. However, identification of such models has not yet been explored in…

Optimization and Control · Mathematics 2020-01-27 Philip E. Pare , Ji Liu , Carolyn L. Beck , Barret E. Kirwan , Tamer Basar

This paper is concerned with the design of intermittent non-pharmaceutical strategies to mitigate the spread of the COVID-19 epidemic exploiting network epidemiological models. Specifically, by studying a variational equation for the…

Populations and Evolution · Quantitative Biology 2022-04-14 Marco Coraggio , Shihao Xie , Francesco De Lellis , Giovanni Russo , Mario di Bernardo

Containment of epidemic outbreaks entails great societal and economic costs. Cost-effective containment strategies rely on efficiently identifying infected individuals, making the best possible use of the available testing resources.…

Populations and Evolution · Quantitative Biology 2020-12-01 Laura Natali , Saga Helgadottir , Onofrio M. Marago , Giovanni Volpe

A coronavirus disease 2019 (COVID-19) model with quarantine and standard incidence rate is first developed, then a novel analysis approach for finding the ultimate lower bound of COVID-19 infectious individuals is proposed, which means that…

Populations and Evolution · Quantitative Biology 2022-11-01 Songbai Guo , Yuling Xue , Xiliang Li , Zuohuan Zheng

We consider the $SEIRS$ epidemiology model with such features of the COVID-19 outbreak as: abundance of unidentified infected individuals, limited time of immunity and a possibility of vaccination. Within a compartmental realization of this…

Populations and Evolution · Quantitative Biology 2021-12-07 Jaroslav Ilnytskyi , Taras Patsahan

This paper introduces a new optimal control model to describe and control the dynamics of infectious diseases. In the present model, the average time of isolation (i.e. hospitalization) of infectious population is the main time-dependent…

Optimization and Control · Mathematics 2015-05-06 Robin J. Evans , Musa Mammadov

Global strategies to contain a pandemic, such as social distancing and protective measures, are designed to reduce the overall transmission rate between individuals. Despite such measures, essential institutions, including hospitals,…

Populations and Evolution · Quantitative Biology 2022-09-07 Roberto Morán-Tovar , Henning Gruell , Florian Klein , Michael Lässig

In the context of epidemiology, policies for disease control are often devised through a mixture of intuition and brute-force, whereby the set of logically conceivable policies is narrowed down to a small family described by a few…

Populations and Evolution · Quantitative Biology 2021-10-04 Miguel Navascues , Costantino Budroni , Yelena Guryanova

Stochastic models are widely used to investigate the spread of epidemics in a complex environment. This paper extends a deterministic SAIRS epidemic model to a stochastic case with limited patient capacity and exposure. We first study the…

Probability · Mathematics 2024-05-20 Xiaohui Zhang , Zhiming Li , Shenglong Chen , Jikai Yang

We analyze an epidemiological model to evaluate the effectiveness of multiple means of control in malaria-endemic areas. The mathematical model consists of a system of several ordinary differential equations, and is based on a…

Populations and Evolution · Quantitative Biology 2023-06-28 Jean Claude Kamgang , Christopher Thron

The novel COVID-19 pandemic is a current, major global health threat. Up till now, there is no fully approved pharmacological treatment or a vaccine. In this study, simple mathematical models were employed to examine the dynamics of…

Physics and Society · Physics 2020-12-25 Ahmed S. Elgazzar

We propose a model for the human immunodeficiency virus type 1 (HIV-1) infection with intracellular delay and prove the local asymptotical stability of the equilibrium points. Then we introduce a control function representing the efficiency…

Optimization and Control · Mathematics 2017-11-01 Filipe Rodrigues , Cristiana J. Silva , Delfim F. M. Torres , Helmut Maurer

We consider a model for an epidemic in a population that occupies geographically distinct locations. The disease is spread within subpopulations by contacts between infective and susceptible individuals, and is spread between subpopulations…

Probability · Mathematics 2016-02-15 R. McVinish , P. K. Pollett , A. Shausan

We consider the SEIRS epidemiology model with such features of the COVID-19 outbreak as: abundance of unidentified infected individuals, limited time of immunity and a possibility of vaccination. The control of the pandemic dynamics is…

Populations and Evolution · Quantitative Biology 2026-03-31 J. Ilnytskyi , T. Patsahan

Mathematical models of cholera and waterborne disease vary widely in their structures, in terms of transmission pathways, loss of immunity, and other features. These differences may yield different predictions and parameter estimates from…

Populations and Evolution · Quantitative Biology 2016-05-24 Elizabeth C. Lee , Michael R. Kelly , Brad M. Ochocki , Segun M. Akinwumi , Karen E. S. Hamre , Joseph H. Tien , Marisa C. Eisenberg

The traditional long-term solutions for epidemic control involve eradication or population immunity. Here, we analytically derive the existence of a third viable solution: a stable equilibrium at low case numbers, where…

Populations and Evolution · Quantitative Biology 2021-10-15 Sebastian Contreras , Jonas Dehning , Sebastian B. Mohr , Simon Bauer , F. Paul Spitzner , Viola Priesemann

We propose and study a new mathematical model of the human immunodeficiency virus (HIV). The main novelty is to consider that the antibody growth depends not only on the virus and on the antibodies concentration but also on the uninfected…

Optimization and Control · Mathematics 2022-01-26 Karam Allali , Sanaa Harroudi , Delfim F. M. Torres

This paper studies an optimal control problem for a class of SIR epidemic models, in scenarios in which the infected population is constrained to be lower than a critical threshold imposed by the ICU (intensive care unit) capacity. The…

Optimization and Control · Mathematics 2024-12-31 Matteo Della Rossa , Lorenzo Freddi , Dan Goreac

We study a dynamics of the epidemiological infection spreading at different values of the risk factor $\beta$ (a control parameter) with the using of dynamic Monte Carlo approach (DMC). In our toy model, the infection transmits due to…

Physics and Society · Physics 2020-06-01 Gennadiy Burlak