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Motivation: Many inference tools use the Perfect Phylogeny Model (PPM) to learn trees from noisy variant allele frequency (VAF) data. Learning in this setting is hard, and existing tools use approximate or heuristic algorithms. An…

Quantitative Methods · Quantitative Biology 2019-08-26 Surjyendu Ray , Bei Jia , Sam Safavi , Tim van Opijnen , Ralph Isberg , Jason Rosch , José Bento

Phylogenetic trees and networks are graphs used to model evolutionary relationships, with trees representing strictly branching histories and networks allowing for events in which lineages merge, called reticulation events. While the…

Populations and Evolution · Quantitative Biology 2026-04-17 Martin Frohn , Niels Holtgrefe , Leo van Iersel , Mark Jones , Steven Kelk

Structural information of phylogenetic tree topologies plays an important role in phylogenetic inference. However, finding appropriate topological structures for specific phylogenetic inference tasks often requires significant design effort…

Machine Learning · Statistics 2023-02-20 Cheng Zhang

Linear model trees are regression trees that incorporate linear models in the leaf nodes. This preserves the intuitive interpretation of decision trees and at the same time enables them to better capture linear relationships, which is hard…

Machine Learning · Statistics 2024-07-10 Jakob Raymaekers , Peter J. Rousseeuw , Tim Verdonck , Ruicong Yao

We consider the numerical taxonomy problem of fitting a positive distance function ${D:{S\choose 2}\rightarrow \mathbb R_{>0}}$ by a tree metric. We want a tree $T$ with positive edge weights and including $S$ among the vertices so that…

Data Structures and Algorithms · Computer Science 2022-03-14 Vincent Cohen-Addad , Debarati Das , Evangelos Kipouridis , Nikos Parotsidis , Mikkel Thorup

In evolutionary biology, networks are becoming increasingly used to represent evolutionary histories for species that have undergone non-treelike or reticulate evolution. Such networks are essentially directed acyclic graphs with a leaf set…

Populations and Evolution · Quantitative Biology 2023-08-23 Katharina T. Huber , Leo van Iersel , Vincent Moulton , Guillaume Scholz

Balanced minimum evolution is a distance-based criterion for the reconstruction of phylogenetic trees. Several algorithms exist to find the optimal tree with respect to this criterion. One approach is to minimize a certain linear functional…

Combinatorics · Mathematics 2019-05-23 Cassandra Durell , Stefan Forcey

In the NP-hard Optimizing PD with Dependencies (PDD) problem, the input consists of a phylogenetic tree $T$ over a set of taxa $X$, a food-web that describes the prey-predator relationships in $X$, and integers $k$ and $D$. The task is to…

Computational Complexity · Computer Science 2024-05-28 Christian Komusiewicz , Jannik Schestag

Lateral transfer, a process whereby species exchange evolutionary traits through non-ancestral relationships, is a frequent source of model misspecification in phylogenetic inference. Lateral transfer obscures the phylogenetic signal in the…

Applications · Statistics 2017-03-20 Luke J. Kelly , Geoff K. Nicholls

Different sources of information might tell different stories about the evolutionary history of a given set of species. This leads to (rooted) phylogenetic trees that "disagree" on triples of species, which we call "conflict triples". An…

Data Structures and Algorithms · Computer Science 2019-11-26 Mathias Weller

Mutation rate variation across loci is well known to cause difficulties, notably identifiability issues, in the reconstruction of evolutionary trees from molecular sequences. Here we introduce a new approach for estimating general…

Probability · Mathematics 2011-09-30 Elchanan Mossel , Sebastien Roch

Although real-coded differential evolution (DE) algorithms can perform well on continuous optimization problems (CoOPs), it is still a challenging task to design an efficient binary-coded DE algorithm. Inspired by the learning mechanism of…

Neural and Evolutionary Computing · Computer Science 2014-05-13 Yu Chen , Weicheng Xie , Xiufen Zou

Evolutionary computation methods have been successfully applied to neural networks since two decades ago, while those methods cannot scale well to the modern deep neural networks due to the complicated architectures and large quantities of…

Neural and Evolutionary Computing · Computer Science 2019-03-12 Yanan Sun , Bing Xue , Mengjie Zhang , Gary G. Yen

The branching structure of biological evolution confers statistical dependencies on phenotypic trait values in related organisms. For this reason, comparative macroevolutionary studies usually begin with an inferred phylogeny that describes…

Populations and Evolution · Quantitative Biology 2012-07-23 Forrest W. Crawford , Marc A. Suchard

This paper presents the novel `uniqueness tree' algorithm, as one possible method for determining whether two finite, undirected graphs are isomorphic. We prove that the algorithm has polynomial time complexity in the worst case, and that…

Discrete Mathematics · Computer Science 2016-06-22 Jonathan Gorard

The evolution of molecular and phenotypic traits is commonly modelled using Markov processes along a phylogeny. This phylogeny can be a tree, or a network if it includes reticulations, representing events such as hybridization or admixture.…

Populations and Evolution · Quantitative Biology 2024-08-28 Benjamin Teo , Paul Bastide , Cécile Ané

Background. The supertree problem, i.e., the task of finding a common refinement of a set of rooted trees is an important topic in mathematical phylogenetics. The special case of a common leaf set $L$ is known to be solvable in linear time.…

Data Structures and Algorithms · Computer Science 2021-09-27 David Schaller , Marc Hellmuth , Peter F. Stadler

Decision trees are popular machine learning models that are simple to build and easy to interpret. Even though algorithms to learn decision trees date back to almost 50 years, key properties affecting their generalization error are still…

Machine Learning · Computer Science 2020-10-16 Jean-Samuel Leboeuf , Frédéric LeBlanc , Mario Marchand

We compare the phylogenetic tensors for various trees and networks for two, three and four taxa. If the probability spaces between one tree or network and another are not identical then there will be phylogenetic tensors that could have…

Populations and Evolution · Quantitative Biology 2016-06-24 Jonathan Mitchell

Reconstructing the tree of life from molecular sequences is a fundamental problem in computational biology. Modern data sets often contain a large number of genes, which can complicate the reconstruction problem due to the fact that…

Probability · Mathematics 2017-07-21 Constantinos Daskalakis , Sebastien Roch