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In Diffusion Probabilistic Models (DPMs), the task of modeling the score evolution via a single time-dependent neural network necessitates extended training periods and may potentially impede modeling flexibility and capacity. To counteract…

Machine Learning · Computer Science 2023-06-06 Etrit Haxholli , Marco Lorenzi

A large number of protein sequences are becoming available through the application of novel high-throughput sequencing technologies. Experimental functional characterization of these proteins is time-consuming and expensive, and is often…

Genomics · Quantitative Biology 2017-09-28 Maxat Kulmanov , Mohammed Asif Khan , Robert Hoehndorf

This paper targets the problem of multi-task dense prediction which aims to achieve simultaneous learning and inference on a bunch of multiple dense prediction tasks in a single framework. A core objective in design is how to effectively…

Computer Vision and Pattern Recognition · Computer Science 2023-07-18 Siwei Yang , Hanrong Ye , Dan Xu

Knowing the location of a protein within the cell is important for understanding its function, role in biological processes, and potential use as a drug target. Much progress has been made in developing computational methods that predict…

Quantitative Methods · Quantitative Biology 2013-08-02 Ramanuja Simha , Hagit Shatkay

Meta-learning enables algorithms to quickly learn a newly encountered task with just a few labeled examples by transferring previously learned knowledge. However, the bottleneck of current meta-learning algorithms is the requirement of a…

Machine Learning · Computer Science 2022-03-18 Huaxiu Yao , Linjun Zhang , Chelsea Finn

Multitask learning assumes that models capable of learning from multiple tasks can achieve better quality and efficiency via knowledge transfer, a key feature of human learning. Though, state of the art ML models rely on high customization…

Machine Learning · Computer Science 2022-11-17 Andrea Gesmundo , Jeff Dean

This paper presents a novel method that allows a machine learning algorithm following the transformation-based learning paradigm \cite{brill95:tagging} to be applied to multiple classification tasks by training jointly and simultaneously on…

Computation and Language · Computer Science 2007-05-23 Radu Florian , Grace Ngai

Recent work has found that multi-task training with a large number of diverse tasks can uniformly improve downstream performance on unseen target tasks. In contrast, literature on task transferability has established that the choice of…

Computation and Language · Computer Science 2022-07-13 Vishakh Padmakumar , Leonard Lausen , Miguel Ballesteros , Sheng Zha , He He , George Karypis

Predicting the mean-field Hamiltonian matrix in density functional theory is a fundamental formulation to leverage machine learning for solving molecular science problems. Yet, its applicability is limited by insufficient labeled data for…

Machine Learning · Computer Science 2024-06-06 He Zhang , Chang Liu , Zun Wang , Xinran Wei , Siyuan Liu , Nanning Zheng , Bin Shao , Tie-Yan Liu

Multi-task learning has shown to significantly enhance the performance of multiple related learning tasks in a variety of situations. We present the fused logistic regression, a sparse multi-task learning approach for binary classification.…

Machine Learning · Statistics 2013-12-31 Venelin Mitov , Manfred Claassen

In this paper, we introduce a novel theoretical framework for multi-task regression, applying random matrix theory to provide precise performance estimations, under high-dimensional, non-Gaussian data distributions. We formulate a…

Understanding and leveraging the 3D structures of proteins is central to a variety of biological and drug discovery tasks. While deep learning has been applied successfully for structure-based protein function prediction tasks, current…

Machine Learning · Computer Science 2024-04-03 Rong Han , Wenbing Huang , Lingxiao Luo , Xinyan Han , Jiaming Shen , Zhiqiang Zhang , Jun Zhou , Ting Chen

We consider the problem of distributed multi-task learning, where each machine learns a separate, but related, task. Specifically, each machine learns a linear predictor in high-dimensional space,where all tasks share the same small…

Machine Learning · Statistics 2015-10-05 Jialei Wang , Mladen Kolar , Nathan Srebro

Numerous deep learning applications benefit from multi-task learning with multiple regression and classification objectives. In this paper we make the observation that the performance of such systems is strongly dependent on the relative…

Computer Vision and Pattern Recognition · Computer Science 2018-04-25 Alex Kendall , Yarin Gal , Roberto Cipolla

Adapting pre-trained models with broad capabilities has become standard practice for learning a wide range of downstream tasks. The typical approach of fine-tuning different models for each task is performant, but incurs a substantial…

Amino acid sequence portrays most intrinsic form of a protein and expresses primary structure of protein. The order of amino acids in a sequence enables a protein to acquire a particular stable conformation that is responsible for the…

Machine Learning · Computer Science 2022-08-29 Ashish Ranjan , Md Shah Fahad , David Fernandez-Baca , Akshay Deepak , Sudhakar Tripathi

Motivation: Protein embedding, which represents proteins as numerical vectors, is a crucial step in various learning-based protein annotation/classification problems, including gene ontology prediction, protein-protein interaction…

Genomics · Quantitative Biology 2024-05-21 Jiayu Shang , Cheng Peng , Yongxin Ji , Jiaojiao Guan , Dehan Cai , Xubo Tang , Yanni Sun

We consider learning a predictive model to be subsequently used for a given downstream task (described by an algorithm) that requires access to the model evaluation. This task need not be prediction, and this situation is frequently…

Machine Learning · Computer Science 2025-06-05 Jianyuan Yin , Qianxiao Li

Accurate prediction of grape phenology is essential for timely vineyard management decisions, such as scheduling irrigation and fertilization, to maximize crop yield and quality. While traditional biophysical models calibrated on historical…

Machine Learning · Computer Science 2025-08-07 William Solow , Sandhya Saisubramanian

Graph convolutional networks have made great progress in graph-based semi-supervised learning. Existing methods mainly assume that nodes connected by graph edges are prone to have similar attributes and labels, so that the features smoothed…

Machine Learning · Computer Science 2022-06-13 Yating Ren , Junzhong Ji , Lingfeng Niu , Minglong Lei
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