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The aim of this paper is to provide a comprehensive review of statistical challenges in neuroimaging data analysis from neuroimaging techniques to large-scale neuroimaging studies to statistical learning methods. We briefly review eight…

Applications · Statistics 2022-10-18 Hongtu Zhu , Tengfei Li , Bingxin Zhao

Neuroimaging has profoundly enhanced our understanding of the human brain by characterizing its structure, function, and connectivity through modalities like MRI, fMRI, EEG, and PET. These technologies have enabled major breakthroughs…

Applications · Statistics 2026-02-16 Jian Kang , Thomas Nichols , Lexin Li , Martin A. Lindquist , Hongtu Zhu

Multi-modality imaging improves disease diagnosis and reveals distinct deviations in tissues with anatomical properties. The existence of completely aligned and paired multi-modality neuroimaging data has proved its effectiveness in brain…

Image and Video Processing · Electrical Eng. & Systems 2023-09-26 Guoyang Xie , Yawen Huang , Jinbao Wang , Jiayi Lyu , Feng Zheng , Yefeng Zheng , Yaochu Jin

By promising more accurate diagnostics and individual treatment recommendations, deep neural networks and in particular convolutional neural networks have advanced to a powerful tool in medical imaging. Here, we first give an introduction…

Machine Learning · Computer Science 2023-01-23 Fabian Eitel , Marc-André Schulz , Moritz Seiler , Henrik Walter , Kerstin Ritter

Analyzing data from multiple neuroimaging studies has great potential in terms of increasing statistical power, enabling detection of effects of smaller magnitude than would be possible when analyzing each study separately and also allowing…

Neuroimaging research has predominantly drawn conclusions based on classical statistics, including null-hypothesis testing, t-tests, and ANOVA. Throughout recent years, statistical learning methods enjoy increasing popularity, including…

Machine Learning · Statistics 2016-05-05 Danilo Bzdok

We describe a system for meta-analysis where a wiki stores numerical data in a simple format and a web service performs the numerical computation. We initially apply the system on multiple meta-analyses of structural neuroimaging data…

Digital Libraries · Computer Science 2012-06-14 Finn Årup Nielsen , Matthew J. Kempton , Steven C. R. Williams

The fast-growing field of Computational Cognitive Neuroscience is on track to meet its first crisis. A large number of papers in this nascent field are developing and testing novel analysis methods using the same stimuli and neuroimaging…

Neurons and Cognition · Quantitative Biology 2021-07-09 Tijl Grootswagers , Amanda K Robinson

Neuromorphic engineering has a data problem. Despite the meteoric rise in the number of neuromorphic datasets published over the past ten years, the conclusion of a significant portion of neuromorphic research papers still states that there…

Computer Vision and Pattern Recognition · Computer Science 2026-02-19 Gregory Cohen , Alexandre Marcireau

Nowadays, the amount of heterogeneous biomedical data is increasing more and more thanks to novel sensing techniques and high-throughput technologies. In reference to biomedical image analysis, the advances in image acquisition modalities…

Image and Video Processing · Electrical Eng. & Systems 2021-06-09 Leonardo Rundo

Deep learning methods have become very popular for the processing of natural images, and were then successfully adapted to the neuroimaging field. As these methods are non-transparent, interpretability methods are needed to validate them…

Computer Vision and Pattern Recognition · Computer Science 2022-04-15 Elina Thibeau-Sutre , Sasha Collin , Ninon Burgos , Olivier Colliot

In this work we perform a meta-analysis of neuroimaging data, consisting of locations of peak activations identified in 162 separate studies on emotion. Neuroimaging meta-analyses are typically performed using kernel-based methods. However,…

Applications · Statistics 2012-06-29 Yu Ryan Yue , Martin A. Lindquist , Ji Meng Loh

Optical imaging of the brain has expanded dramatically in the past two decades. New optics, indicators, and experimental paradigms are now enabling in-vivo imaging from the synaptic to the cortex-wide scales. To match the resulting flood of…

Image and Video Processing · Electrical Eng. & Systems 2024-02-15 Gal Mishne , Adam Charles

With the rapid growth of modern technology, many large-scale biomedical studies have been/are being/will be conducted to collect massive datasets with large volumes of multi-modality imaging, genetic, neurocognitive, and clinical…

Methodology · Statistics 2018-03-07 Farouk S. Nathoo , Linglong Kong , Hongtu Zhu

Normative modelling is an increasingly common statistical technique in neuroimaging that estimates population-level benchmarks in brain structure. It enables the quantification of individual deviations from expected distributions whilst…

Neurons and Cognition · Quantitative Biology 2025-10-21 Nida Alyas , Jonathan Horsley , Bethany Little , Peter N. Taylor , Yujiang Wang , Karoline Leiberg

Advances in computing power, deep learning architectures, and expert labelled datasets have spurred the development of medical imaging artificial intelligence systems that rival clinical experts in a variety of scenarios. The National…

Image and Video Processing · Electrical Eng. & Systems 2021-11-18 Rohan Shad , John P. Cunningham , Euan A. Ashley , Curtis P. Langlotz , William Hiesinger

The combination of deep learning image analysis methods and large-scale imaging datasets offers many opportunities to imaging neuroscience and epidemiology. However, despite the success of deep learning when applied to many neuroimaging…

Image and Video Processing · Electrical Eng. & Systems 2021-07-14 Nicola K Dinsdale , Emma Bluemke , Vaanathi Sundaresan , Mark Jenkinson , Stephen Smith , Ana IL Namburete

Meta-analysis is commonly used to combine results from multiple clinical trials, but traditional meta-analysis methods do not refer explicitly to a population of individuals to whom the results apply and it is not clear how to use their…

Machine learning provides a valuable tool for analyzing high-dimensional functional neuroimaging data, and is proving effective in predicting various neurological conditions, psychiatric disorders, and cognitive patterns. In functional…

Machine Learning · Computer Science 2024-11-25 Anwar Said , Roza G. Bayrak , Tyler Derr , Mudassir Shabbir , Daniel Moyer , Catie Chang , Xenofon Koutsoukos
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