Related papers: Nonwoven scaffolds for bone regeneration
Bone is a biomaterial undergoing continuous renewal. The renewal process is known as bone remodelling and is operated by bone-resorbing cells (osteoclasts) and bone-forming cells (osteoblasts). Both biochemical and biomechanical regulatory…
Biological composites offer self-healing properties, biocompatibility, high responsivity to external stimuli, and multifunctionality, due, in part, to their complex, hierarchical microstructure. Such materials can be inexpensively grown,…
Biological hydrogels have been increasingly sought after as e.g. wound dressings or scaffolds for regenerative medicine, due to their inherent biofunctionality in biological environments. Especially in moist wound healing, the ideal…
Currently, a large number of stored tissue samples are unavailable for spectroscopic study without the time consuming and destructive process of paraffin removal. Instead, a structurally sensitive technique, sum frequency generation, and a…
Bone remodeling involves the coordinated removal of bone by osteoclasts and addition of bone by osteoblasts, a process that is modulated by the prevailing mechanical environment. In this paper a fully coupled model of bone remodeling is…
Soft stretchable materials are key for arising technologies such as stretchable electronics or batteries, smart textiles, biomedical devices, tissue engineering and soft robotics. Recent attempts to design such materials, via e.g.…
Substrate engineering for steering cell growth is a wide and well-established area of research in the field of modern biotechnology. Here we introduce a micromachining technique to pattern an inert, transparent polymer matrix blended with a…
Conventional tissue engineering methodologies frequently depend on pharmacological strategies to induce or expedite tissue repair. However, bioengineered strategies incorporating biophysical stimulation have emerged as promising…
Critical sized bone defects remain a major clinical challenge, requiring scaffolds that combine mechanical stability with regenerative capacity. Functionally graded (FG) scaffolds, inspired by the graded architecture of native bone, offer a…
Understanding complex biological macromolecules, especially proteins, is vital for grasping their diverse chemical functions with direct impact in biology and pharmacology. While techniques like X-ray crystallography and cryo-electron…
Additive manufacturing (AM) techniques have gained interest in the tissue engineering field thanks to their versatility and unique possibilities of producing constructs with complex macroscopic geometries and defined patterns. Recently,…
In the last ten years, the average annual growth rate of nonwoven production was 4%. In 2020 and 2021, nonwoven production has increased even further due to the huge demand for nonwoven products needed for protective clothing such as FFP2…
Systems of "living" polymers are ubiquitous in industry and are traditionally realised using surfactants. Here I review the state-of-the-art of living polymers and discuss non-equilibrium extensions that may be realised with advanced…
The technique presented here identifies tethered mould designs, optimised for growing cultured tissue with very highly-aligned cells. It is based on a microscopic biophysical model for polarised cellular hydrogels. There is an unmet need…
To accelerate the development of strategies for cartilage tissue engineering, models are necessary to study the interactions between cellular dynamics and scaffold (SC) porosity. In experiments, cells are seeded in a porous SC where over a…
Deployable structures, essential across various engineering applications ranging from umbrellas to satellites, are evolving to include soft, morphable designs where geometry drives transformation. However, a major challenge for soft…
Bone is a living material. It adapts, in an optimal sense, to loading by changing its density and trabeculae architecture - a process termed remodelling. Implanted orthopaedic devices can significantly alter the loading on the surrounding…
The use of colloidal supported lipid bilayers (CSLBs) has recently been extended to create colloidal joints, that - in analogy to their macroscopic counterparts - can flexibly connect colloidal particles. These novel elements enable the…
Through evolution, nature has presented a set of remarkable protein materials, including elastins, silks, keratins and collagens with superior mechanical performances that play crucial roles in mechanobiology. However, going beyond natural…
Antimicrobial biomaterials are critical to aid in the regeneration of oral soft tissue and prevent or treat localised bacterial infections. With the rising trend in antibiotic resistance, there is a pressing clinical need for new…