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Various new brain-computer interface technologies or neuroscience applications require decoding stimulus-following neural responses to natural stimuli such as speech and video from, e.g., electroencephalography (EEG) signals. In this…
The prediction of subjects with mild cognitive impairment (MCI) who will progress to Alzheimer's disease (AD) is clinically relevant, and may above all have a significant impact on accelerate the development of new treatments. In this…
In the fields of neuroimaging and genetics, a key goal is testing the association of a single outcome with a very high-dimensional imaging or genetic variable. Often, summary measures of the high-dimensional variable are created to…
In addition to objective indicators (e.g. laboratory values), clinical data often contain subjective evaluations by experts (e.g. disease severity assessments). While objective indicators are more transparent and robust, the subjective…
Many automatic machine learning models developed for focal pathology (e.g. lesions, tumours) detection and segmentation perform well, but do not generalize as well to new patient cohorts, impeding their widespread adoption into real…
We investigate saddlepoint approximations applied to the score test statistic in genome-wide association studies with binary phenotypes. The inaccuracy in the normal approximation of the score test statistic increases with increasing sample…
Sharpness-Aware Minimization (SAM) and adaptive sharpness-aware minimization (ASAM) aim to improve the model generalization. And in this project, we proposed three experiments to valid their generalization from the sharpness aware…
Within the Compressive Sensing (CS) paradigm, sparse signals can be reconstructed based on a reduced set of measurements. Reliability of the solution is determined by the uniqueness condition. With its mathematically tractable and feasible…
We present a new system based on tracking the temporal evolution of stroke lesions using an image registration technique on CT exams of the patient's brain. The system is able to compare past CT exams with the most recent one related to…
We study the maximum score statistic to detect and estimate local signals in the form of change-points in the level, slope, or other property of a sequence of observations, and to segment the sequence when there appear to be multiple…
The literature comparing the performance of algorithms for assigning cause of death using verbal autopsy data is fractious and does not reach a consensus on which algorithms perform best, or even how to do the comparison. This manuscript…
Spinal cord stimulation has enabled humans with motor complete spinal cord injury (SCI) to independently stand and recover some lost autonomic function. Quantifying the quality of bipedal standing under spinal stimulation is important for…
Autonomic Dysreflexia (AD) is a potentially life-threatening condition characterized by sudden, severe blood pressure (BP) spikes in individuals with spinal cord injury (SCI). Early, accurate detection is essential to prevent cardiovascular…
Brain-computer interfaces (BCIs), is ways for electronic devices to communicate directly with the brain. For most medical-type brain-computer interface tasks, the activity of multiple units of neurons or local field potentials is sufficient…
The intraclass correlation coefficient (ICC) is a classical index of measurement reliability. With the advent of new and complex types of data for which the ICC is not defined, there is a need for new ways to assess reliability. To meet…
Vibration injury in the hand-arm system from hand-held machines is one of the most common occupational health injuries and causes severe and often chronic nerve and vascular injury to the operator. Machines emitting shock vibrations, e.g.,…
Traditional echocardiographic parameters such as ejection fraction (EF) and global longitudinal strain (GLS) have limitations in the early detection of cardiac dysfunction. EF often remains normal despite underlying pathology, and GLS is…
This paper investigates the problem of recovering missing samples using methods based on sparse representation adapted especially for image signals. Instead of $l_2$-norm or Mean Square Error (MSE), a new perceptual quality measure is used…
Randomized clinical trials are the gold standard when estimating the average treatment effect. However, they are usually not a random sample from the real-world population because of the inclusion/exclusion rules. Meanwhile, observational…
A generalization of the classical concordance correlation coefficient (CCC) is considered under a three-level design where multiple raters rate every subject over time, and each rater is rating every subject multiple times at each measuring…