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Optimization of fluid transport in the slime mold Physarum polycephalum has been the subject of several modeling efforts in recent literature. Existing models assume that the tube adaptation mechanism in P. polycephalum's tubular network is…

Tissues and Organs · Quantitative Biology 2019-07-01 Vincenzo Bonifaci

Physarum Polycephalum is a unicellular slime mold that has been intensely studied due to its ability to solve mazes, find shortest paths, generate Steiner trees, share knowledge, remember past events, and its applications to unconventional…

Biological Physics · Physics 2022-10-18 Sheryl Hsu , Laura P. Schaposnik

The plasmodium of the true slime mold Physarum polycephalum serves as a platform to study information processing in non-equilibrium active matter, showing complex oscillations and computation despite its simple morphology. Past experiments…

Biological Physics · Physics 2025-04-07 Suyash Bajpai , Masashi Aono , Philip Kurian

Physarum Polycephalum is a slime mold that can solve shortest path problems. A mathematical model based on Physarum's behavior, known as the Physarum Directed Dynamics, can solve positive linear programs. In this paper, we present a family…

Data Structures and Algorithms · Computer Science 2022-07-19 Yuan Gao , Hamidreza Kamkari , Andreas Karrenbauer , Kurt Mehlhorn , Mohammadamin Sharifi

Many studies have shown that Physarum polycephalum slime mold is able to find the shortest path in a maze. In this paper we study this behavior in a network, using a hyperbolic model of chemotaxis. Suitable transmission and boundary…

Numerical Analysis · Mathematics 2016-01-07 Gabriella Bretti , Roberto Natalini

The slime mould Physarum polycephalum displays adaptive transport dynamics and network formation that have inspired its use as a model of biological computation. We develop a Lagrangian formulation of Physarum's adaptive dynamics on…

Neurons and Cognition · Quantitative Biology 2025-11-12 Ricard Solé , Jordi Pla-Mauri

Plasmodium of Physarum polycephalum is a large single cell visible by unaided eye. It shows sophisticated behavioural traits in foraging for nutrients and developing an optimal transport network of protoplasmic tubes spanning sources of…

Emerging Technologies · Computer Science 2013-05-03 Andrew Adamatzky , Genaro J. Martinez

The slime mould Physarum polycephalum has emerged as a model for self-organisation and coordination of contractile activity at large spatial scales. This self-organisation largely results from cytoplasmic flows generated by propagating…

Soft Condensed Matter · Physics 2025-09-23 Raphael Saiseau , Valentin Busson , Marc Durand

We present Monte Carlo Physarum Machine: a computational model suitable for reconstructing continuous transport networks from sparse 2D and 3D data. MCPM is a probabilistic generalization of Jones's 2010 agent-based model for simulating the…

Cosmology and Nongalactic Astrophysics · Physics 2022-04-05 Oskar Elek , Joseph N. Burchett , J. Xavier Prochaska , Angus G. Forbes

We consider a system of nonlinear ordinary differential equations for the solution of linear programming (LP) problems that was first proposed in the mathematical biology literature as a model for the foraging behavior of acellular slime…

Optimization and Control · Mathematics 2021-03-30 Vincenzo Bonifaci

Decision-making is the process of selecting an action among alternatives, allowing biological and artificial systems to navigate complex environments and optimize behavior. While neural systems rely on neuron-based sensory processing and…

Biological Physics · Physics 2025-06-17 Lisa Schick , Emily Eichenlaub , Fabian Drexel , Alexander Mayer , Siyu Chen , Marcus Roper , Karen Alim

Plasmodium of true slime mold, Physarum polycephalum, is an amoeboid organism, which spreads with developing tubular network structure and crawls on two-dimensional plane with oscillating the cell thickness. The plasmodium transforms its…

Adaptation and Self-Organizing Systems · Physics 2009-04-10 Yuki Kagawa , Atsuko Takamatsu

The aim of this work is to quantify the spatio-temporal dynamics of flow-driven amoeboid locomotion in small ($\sim$100 $\mu$m) fragments of the true slime mold \phys {\it polycephalum}. In this model organism, cellular contraction drives…

Cell Behavior · Quantitative Biology 2017-05-24 Shun Zhang , Robert D. Guy , Juan C. Lasheras , Juan C. del Alamo

Many cells face search problems, such as finding food, mates or shelter, where their success depends on their search strategy. In contrast to other unicellular organisms, the slime mold Physarum polycephalum forms a giant network-shaped…

Biological Physics · Physics 2024-09-20 Lucas Tröger , Florian Goirand , Karen Alim

Belgium is amongst few artificial countries, established on purpose, when Dutch and French speaking parts were joined in a single unit. This makes Belgium a particularly interesting testbed for studying bio-inspired techniques for…

Adaptation and Self-Organizing Systems · Physics 2011-12-21 Andrew Adamatzky , Bernard De Baets , Wesley Van Dessel

Plasmodium of Physarum polycephalum is a large cell, visible by unaided eye, which exhibits sophisticated patterns of foraging behaviour. The plasmodium's behaviour is well interpreted in terms of computation, where data are spatially…

Pattern Formation and Solitons · Physics 2012-06-25 Andrew Adamatzky

Computing a polygon defining a set of planar points is a classical problem of modern computational geometry. In laboratory experiments we demonstrate that a concave hull, a connected alpha-shape without holes, of a finite planar set is…

Emerging Technologies · Computer Science 2012-06-26 Andrew Adamatzky

Physarum polycephalum is a large single amoeba cell, which in its plasmodial phase,forages and connects nearby food sources with protoplasmic tubes. The organism forages for food by growing these tubes towards detected food stuffs, this…

Emerging Technologies · Computer Science 2014-06-10 James G. H. Whiting , Ben P. J. de Lacy Costello , Andrew Adamatzky

The slime mould Physarum polycephalum is a suitable candidate organism for soft-matter robotics because it exhibits controllable transport, movement and guidance behaviour. Physarum may be considered as a smart computing and actuating…

Adaptation and Self-Organizing Systems · Physics 2012-12-05 Soichiro Tsuda , Jeff Jones , Andrew Adamatzky

Slime mould Physarum polycephalum is large single cell with intriguingly smart behaviour. The slime mould shows outstanding abilities to adapt its protoplasmic network to varying environmental conditions. The slime mould can solve tasks of…

Emerging Technologies · Computer Science 2013-04-09 Andrew Adamatzky , Rachel Armstrong , Jeff Jones , Yukio-Pegio Gunji
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