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Partially observable Markov decision processes (POMDPs) provide an elegant mathematical framework for modeling complex decision and planning problems in stochastic domains in which states of the system are observable only indirectly, via a…

Artificial Intelligence · Computer Science 2011-06-02 M. Hauskrecht

In many domains, scientists build complex simulators of natural phenomena that encode their hypotheses about the underlying processes. These simulators can be deterministic or stochastic, fast or slow, constrained or unconstrained, and so…

Machine Learning · Statistics 2014-12-10 Edward Meeds , Michael Chiang , Mary Lee , Olivier Cinquin , John Lowengrub , Max Welling

The generation of 3D molecules requires simultaneously deciding the categorical features~(atom types) and continuous features~(atom coordinates). Deep generative models, especially Diffusion Models (DMs), have demonstrated effectiveness in…

Machine Learning · Computer Science 2023-12-13 Yuxuan Song , Jingjing Gong , Minkai Xu , Ziyao Cao , Yanyan Lan , Stefano Ermon , Hao Zhou , Wei-Ying Ma

Constrained Optimum Path (COP) problems appear in many real-life applications, especially on communication networks. Some of these problems have been considered and solved by specific techniques which are usually difficult to extend. In…

Artificial Intelligence · Computer Science 2009-10-08 Quang Dung Pham , Yves Deville , Pascal Van Hentenryck

Phononic crystals and acoustic meta-materials are used to tailor phonon and sound propagation properties by facilitating artificial, periodic structures. Analogous to photonic crystals, phononic band gaps can be created, which influence…

Mesoscale and Nanoscale Physics · Physics 2014-09-18 Daniel Midtvedt , Andreas Isacsson , Alexander Croy

Machine-learned interatomic potentials (MLIPs) are increasingly used to replace computationally demanding electronic-structure calculations to model matter at the atomic scale. The most commonly used model architectures are constrained to…

Chemical Physics · Physics 2026-03-30 Filippo Bigi , Paolo Pegolo , Arslan Mazitov , Jonathan Schmidt , Michele Ceriotti

The central approximation made in classical molecular dynamics simulation of materials is the interatomic potential used to calculate the forces on the atoms. Great effort and ingenuity is required to construct viable functional forms and…

Computational Physics · Physics 2019-06-26 Mitchell A. Wood , Mary Alice Cusentino , Brian D. Wirth , Aidan P. Thompson

Machine Learning (ML) approximations to Density Functional Theory (DFT) potential energy surfaces (PESs) are showing great promise for reducing the computational cost of accurate molecular simulations, but at present they are not applicable…

Chemical Physics · Physics 2020-03-05 Xiaowei Xie , Kristin A. Persson , David W. Small

In reaction path optimization, such as the calculation of a minimum energy path (MEP) between given reactant and product configurations of atoms, it is advantageous to start with an initial guess where close proximity of atoms is avoided…

Chemical Physics · Physics 2023-10-10 Yorick L. A. Schmerwitz , Vilhjálmur Ásgeirsson , Hannes Jónsson

Automatic melody generation for pop music has been a long-time aspiration for both AI researchers and musicians. However, learning to generate euphonious melody has turned out to be highly challenging due to a number of factors.…

Empirical force fields employed in molecular dynamics simulations of complex systems can be optimised to reproduce experimentally determined structural and thermodynamic properties. In contrast, experimental knowledge about the rates of…

Statistical Mechanics · Physics 2022-07-12 P. G. Bolhuis , Z. F. Brotzakis , B. G. Keller

Multi-objective optimization problems (MOPs) require the simultaneous optimization of conflicting objectives. Real-world MOPs often exhibit complex characteristics, including high-dimensional decision spaces, many objectives, or…

Neural and Evolutionary Computing · Computer Science 2025-10-20 Haokai Hong , Liang Feng , Min Jiang , Kay Chen Tan

Machine-learned interatomic potentials can offer near first-principles accuracy but are computationally expensive, limiting their application to large-scale molecular dynamics simulations. Inspired by quantum mechanics/molecular mechanics…

Materials Science · Physics 2025-11-21 Fraser Birks , Matthew Nutter , Thomas D Swinburne , James R Kermode

Topology Optimization seeks to find the best design that satisfies a set of constraints while maximizing system performance. Traditional iterative optimization methods like SIMP can be computationally expensive and get stuck in local…

Machine Learning · Computer Science 2023-03-20 Giorgio Giannone , Faez Ahmed

Optimal pulse patterns (OPPs) are a modulation technique in which a switching signal is computed offline through an optimization process that accounts for selected performance criteria, such as current harmonic distortion. The optimization…

Systems and Control · Electrical Eng. & Systems 2025-12-10 Jared Miller , Petros Karamanakos , Tobias Geyer

Enhanced sampling algorithms have emerged as powerful methods to extend the utility of molecular dynamics simulations and allow the sampling of larger portions of the configuration space of complex systems in a given amount of simulation…

Statistical Mechanics · Physics 2022-12-19 Jérôme Hénin , Tony Lelièvre , Michael R. Shirts , Omar Valsson , Lucie Delemotte

Genetic regulatory circuits universally cope with different sources of noise that limit their ability to coordinate input and output signals. In many cases, optimal regulatory performance can be thought to correspond to configurations of…

Molecular Networks · Quantitative Biology 2018-02-19 Andrea Crisanti , Andrea De Martino , Jonathan Fiorentino

We show how additional constraints, restricting the spectrum of the optimized pulse or confining the system dynamics, can be used to steer optimization in quantum control towards distinct solutions. Our examples are multi-photon excitation…

Quantum Physics · Physics 2013-11-18 José P. Palao , Daniel M. Reich , Christiane P. Koch

We present an accurate machine learning (ML) model for atomistic simulations of carbon, constructed using the Gaussian approximation potential (GAP) methodology. The potential, named GAP-20, describes the properties of the bulk crystalline…

Computational Physics · Physics 2020-08-26 Patrick Rowe , Volker L Deringer , Piero Gasparotto , Gábor Csányi , Angelos Michaelides

Hybrid organic-inorganic perovskites (HOIPs) have become an important class of semiconductors for solar cells and other optoelectronic applications. Electron-phonon coupling plays a critical role in all optoelectronic devices, and although…