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A massive dataset often consists of a growing number of (potentially) heterogeneous sub-populations. This paper is concerned about testing various forms of heterogeneity arising from massive data. In a general nonparametric framework, a set…

Statistics Theory · Mathematics 2016-01-26 Junwei Lu , Guang Cheng , Han Liu

We consider an asexual population under strong selection-weak mutation conditions evolving on rugged fitness landscapes with many local fitness peaks. Unlike the previous studies in which the initial fitness of the population is assumed to…

Populations and Evolution · Quantitative Biology 2011-11-18 Kavita Jain , Sarada Seetharaman

In large populations, multiple beneficial mutations may be simultaneously spreading. In asexual populations, these mutations must either arise on the same background or compete against each other. In sexual populations, recombination can…

Populations and Evolution · Quantitative Biology 2013-12-19 D. B. Weissman , O. Hallatschek

In this paper, we review recent results of ours concerning branching processes with general lifetimes and neutral mutations, under the infinitely many alleles model, where mutations can occur either at birth of individuals or at a constant…

Probability · Mathematics 2012-11-29 Nicolas Champagnat , Amaury Lambert , Mathieu Richard

In the first paper of this series, we included the effects of population genetics in the agent-based Monte Carlo code HERITAGE under the hypothesis of neutral phenotypic effects. It implied that mutations (genetic changes) had only neutral…

Popular Physics · Physics 2025-02-12 Frédéric Marin , Camille Beluffi-Marin , Frédéric Fischer

We consider a neutral dynamical model of biological diversity, where individuals live and reproduce independently. They have i.i.d. lifetime durations (which are not necessarily exponentially distributed) and give birth (singly) at constant…

Populations and Evolution · Quantitative Biology 2010-09-06 Nicolas Champagnat , Amaury Lambert

We introduce a modified spatial $\Lambda$-Fleming-Viot process to model the ancestry of individuals in a population occupying a continuous spatial habitat divided into two areas by a sharp discontinuity of the dispersal rate and effective…

Probability · Mathematics 2023-06-14 Raphael Forien , Harald Ringbauer , Graham Coop

A fundamental problem in the fields of population genetics, evolution, and community ecology, is the fate of a single mutant, or invader, introduced in a finite population of wild types. For a fixed-size community of $N$ individuals, with…

Populations and Evolution · Quantitative Biology 2017-10-25 Matan Danino , Nadav M. Shnerb

The prediction of phenotypic traits using high-density genomic data has many applications such as the selection of plants and animals of commercial interest; and it is expected to play an increasing role in medical diagnostics. Statistical…

Methodology · Statistics 2016-09-29 Marco Scutari , Ian Mackay , David Balding

In evolutionary dynamics, a key measure of a mutant trait's success is the probability that it takes over the population given some initial mutant-appearance distribution. This "fixation probability" is difficult to compute in general, as…

Populations and Evolution · Quantitative Biology 2022-02-18 Alex McAvoy , Benjamin Allen

Fundamental properties of macroscopic gene-mating dynamic evolutionary systems are investigated. We focus on a single locus, any number of alleles in a two-gender dioecious population, for a large class of systems within population…

Populations and Evolution · Quantitative Biology 2020-07-22 Juven Wang , Jiunn-Wei Chen

We show that training of generative adversarial network (GAN) may not have good generalization properties; e.g., training may appear successful but the trained distribution may be far from target distribution in standard metrics. However,…

Machine Learning · Computer Science 2017-08-03 Sanjeev Arora , Rong Ge , Yingyu Liang , Tengyu Ma , Yi Zhang

Game theoretic tools are utilized to analyze a one-locus continuous selection model of sex-specific meiotic drive by considering nonequivalence of the viabilities of reciprocal heterozygotes that might be noticed at an imprinted locus. The…

Populations and Evolution · Quantitative Biology 2015-12-07 Bijan Sarkar

Aggregation-diffusion equations are foundational tools for modelling biological aggregations. Their principal use is to link the collective movement mechanisms of organisms to their emergent space use patterns in a concrete mathematical…

Populations and Evolution · Quantitative Biology 2025-04-16 Jonathan R. Potts

In the analysis of complex traits, genetic effects are frequently modelled as either fixed or random effects. Such assumptions serve as a foundation of defining heritability and relatedness using genome-wide single nucleotide polymorphism…

Populations and Evolution · Quantitative Biology 2023-04-28 Hanbin Lee

Environmental changes greatly influence the evolution of populations. Here, we study the dynamics of a population of two strains, one growing slightly faster than the other, competing for resources in a time-varying binary environment…

Populations and Evolution · Quantitative Biology 2020-07-28 Ami Taitelbaum , Robert West , Michael Assaf , Mauro Mobilia

We present an individual-based model for two interacting populations diffusing on lattices in which a strong natural selection develops spontaneously. The models combine traditional local predator-prey dynamics with random walks.…

Populations and Evolution · Quantitative Biology 2007-05-23 Monica F. B. Moreira , Marcio P. Dantas , A. T. Costa

The evolution of dispersal is a classical question in evolutionary ecology, which has been widely studied with several mathematical models. The main question is to define the fittest dispersal rate for a population in a bounded domain, and,…

Analysis of PDEs · Mathematics 2016-02-26 Benoit Perthame , Panagiotis E. Souganidis

Understanding the forces shaping ecological communities is crucially important to basic science and conservation. In recent years, considerable progress was made in explaining communities using simple and general models, with neutral theory…

Populations and Evolution · Quantitative Biology 2014-06-12 Michael Kalyuzhny , Ronen Kadmon , Nadav M. Shnerb

Our goal is to study the genetic composition of a population in which each individual has 2 parents, who contribute equally to the genome of their ospring. We use a biparental Moran model, which is characterized by its xed number N of…

Probability · Mathematics 2022-04-01 Camille Coron , Yves Le Jan