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Investigations of the human connectome have elucidated core features of adult structural networks, particularly the crucial role of hub-regions. However, little is known regarding network organisation of the healthy elderly connectome, a…

Neurons and Cognition · Quantitative Biology 2015-12-15 Alistair Perry , Wei Wen , Anton Lord , Anbupalam Thalamuthu , Perminder Sachdev , Michael Breakspear

Recent advances in molecular and genetic research have identified a diverse range of brain tumor sub-types, shedding light on differences in their molecular mechanisms, heterogeneity, and origins. The present study performs whole-brain…

Neurons and Cognition · Quantitative Biology 2024-07-26 Debanjali Bhattacharya , Ninad Aithal , Manish Jayswal , Neelam Sinha

We describe a scalable database cluster for the spatial analysis and annotation of high-throughput brain imaging data, initially for 3-d electron microscopy image stacks, but for time-series and multi-channel data as well. The system was…

Neuropsychiatric disorders impact functional connectivity of the brain at the network level. The identification and statistical testing of disorder-related networks remains challenging. We propose novel methods to streamline the detection…

Applications · Statistics 2017-01-16 Shuo Chen , Yishi Xing , Jian Kang , Dinesh Shukla , Peter Kochunov , L. Elliot Hong

The characterisation of the brain as a "connectome", in which the connections are represented by correlational values across timeseries and as summary measures derived from graph theory analyses, has been very popular in the last years.…

Machine Learning · Computer Science 2020-03-13 Tiago Azevedo , Luca Passamonti , Pietro Liò , Nicola Toschi

With recent advancements in non-invasive techniques for measuring brain activity, such as magnetic resonance imaging (MRI), the study of structural and functional brain networks through graph signal processing (GSP) has gained notable…

Machine Learning · Computer Science 2025-11-13 Martín Schmidt , Sara Silva , Federico Larroca , Gonzalo Mateos , Pablo Musé

Brain networks are typically represented by adjacency matrices, where each node corresponds to a brain region. In traditional brain network analysis, nodes are assumed to be matched across individuals, but the methods used for node matching…

Methodology · Statistics 2025-03-21 Martin Cole , Yang Xiang , Will Consagra , Anuj Srivastava , Xing Qiu , Zhengwu Zhang

In brain connectomics, the cortical surface is parcellated into different regions of interest (ROIs) prior to statistical analysis. The brain connectome for each individual can then be represented as a graph, with the nodes corresponding to…

Methodology · Statistics 2020-10-07 Steven Winter , Zhengwu Zhang , David Dunson

One of the crucial questions in neuroscience is how a rich functional repertoire of brain states relates to its underlying structural organization. How to study the associations between these structural and functional layers is an open…

Neurons and Cognition · Quantitative Biology 2018-02-22 Enrico Amico , Joaquín Goñi

Human brains lie at the core of complex neurobiological systems, where the neurons, circuits, and subsystems interact in enigmatic ways. Understanding the structural and functional mechanisms of the brain has long been an intriguing pursuit…

Neurons and Cognition · Quantitative Biology 2022-07-26 Hejie Cui , Wei Dai , Yanqiao Zhu , Xiaoxiao Li , Lifang He , Carl Yang

Anatomical connectivity between different regions in the brain can be mapped to a network representation, the connectome, where the intensities of the links, the weights, influence its structural resilience and the functional processes it…

Neurons and Cognition · Quantitative Biology 2025-04-09 Laia Barjuan , Muhua Zheng , M. Ángeles Serrano

Exploring the complex structure of the human brain is crucial for understanding its functionality and diagnosing brain disorders. Thanks to advancements in neuroimaging technology, a novel approach has emerged that involves modeling the…

Machine Learning · Computer Science 2024-06-06 Xuexiong Luo , Jia Wu , Jian Yang , Shan Xue , Amin Beheshti , Quan Z. Sheng , David McAlpine , Paul Sowman , Alexis Giral , Philip S. Yu

Advanced brain imaging techniques make it possible to measure individuals' structural connectomes in large cohort studies non-invasively. The structural connectome is initially shaped by genetics and subsequently refined by the environment.…

Applications · Statistics 2018-06-11 Zhengwu Zhang , Genevera I. Allen , Hongtu Zhu , David Dunson

Cognitive task classification using machine learning plays a central role in decoding brain states from neuroimaging data. By integrating machine learning with brain network analysis, complex connectivity patterns can be extracted from…

Machine Learning · Computer Science 2026-01-01 Debasis Maji , Arghya Banerjee , Debaditya Barman

The human connectome is the object of an intensive research today. In these graphs, the vertices correspond to the small areas of the gray matter, and two vertices are connected by an edge, if a diffusion-MRI based workflow finds…

Neurons and Cognition · Quantitative Biology 2016-09-28 Csaba Kerepesi , Balázs Szalkai , Bálint Varga , Vince Grolmusz

A recent publication provides the network graph for a neocortical microcircuit comprising 8 million connections between 31,000 neurons (H. Markram, et al., Reconstruction and simulation of neocortical microcircuitry, Cell, 163 (2015) no. 2,…

Neurons and Cognition · Quantitative Biology 2017-06-13 Pawe Dotko , Kathryn Hess , Ran Levi , Max Nolte , Michael Reimann , Martina Scolamiero , Katharine Turner , Eilif Muller , Henry Markram

Gaussian blurring is a well-established method for image data augmentation: it may generate a large set of images from a small set of pictures for training and testing purposes for Artificial Intelligence (AI) applications. When we apply AI…

Neurons and Cognition · Quantitative Biology 2020-10-22 Laszlo Keresztes , Evelin Szogi , Balint Varga , Vince Grolmusz

In our previous study we have shown that the female connectomes have significantly better, deep graph-theoretical parameters, related to superior "connectivity", than the connectome of the males. Since the average female brain is smaller…

Neurons and Cognition · Quantitative Biology 2015-12-04 Balázs Szalkai , Bálint Varga , Vince Grolmusz

Visualizing brain functional connectivity (FC) patterns is essential for understanding neural organization, yet existing tools such as Circos and BrainNet Viewer require complex configuration files or proprietary software environments. We…

Human-Computer Interaction · Computer Science 2026-03-31 Xiao Fan , Yi Zhang

Mapping the brain imaging data to networks, where each node represents a specific area of the brain, has enabled an objective graph-theoretic analysis of human connectome. However, the latent structure on higher-order connections remains…

Neurons and Cognition · Quantitative Biology 2019-04-09 Bosiljka Tadic , Miroslav Andjelkovic , Roderick Melnik