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Multiple light scattering in tissue limits the penetration of optical coherence tomography (OCT) imaging. Here, we present in-vivo OCT imaging of a live mouse using wavefront shaping to enhance the penetration depth. A digital micro-mirror…

Optical Coherence Tomography (OCT) has become an indispensable tool for investigating mesoscopic features in soft matter and fluid mechanics. Its ability to provide high-resolution, non-invasive measurements in both spatial and temporal…

Optical coherence tomography (OCT) uses low-coherence reflectometry to obtain cross-sectional images of inhomogeneous media, such as biological tissue. OCT is particularly useful in the biomedical ea, since the imaging can be performed…

Medical Physics · Physics 2018-03-01 Takahisa Mitsui , Kenichiro Aoki

Holographic optical coherence tomography (OCT) is a powerful imaging technique, but its ability to reveal low-reflectivity features is limited. In this study, we performed holographic OCT by incoherently averaging volumes with changing…

Optical Coherence Tomography (OCT) is one of the most emerging imaging modalities that has been used widely in the field of biomedical imaging. From its emergence in 1990's, plenty of hardware and software improvements have been made. Its…

Computer Vision and Pattern Recognition · Computer Science 2014-11-18 Ahmadreza Baghaie , Roshan M. D'souza , Zeyun Yu

Optical coherence tomography (OCT) is a widely used imaging technique in the micrometer regime, which gained accelerating interest in medical imaging in the last twenty years. In up-to-date OCT literature [5,6] certain simplifying…

Medical Physics · Physics 2024-02-23 Leopold Veselka , Lisa Krainz , Leonidas Mindrinos , Wolfgang Drexler , Peter Elbau

Deep, high-resolution imaging is essential for unraveling biological complexity and advancing medical diagnostics, yet scattering fundamentally limits optical methods. Among the most promising approaches, photoacoustic imaging achieves…

Optical-coherence tomography (OCT) is a technique that employs light in order to measure the internal structure of semi-transparent, e.g. biological, samples. It is based on the interference pattern of low-coherence light. Quantum-OCT…

Optical wavefront-shaping has emerged as a powerful tool to manipulate light in strongly scattering media. It enables diffraction-limited focusing and imaging at depths where conventional microscopy techniques fail. However, while most…

Optics · Physics 2014-03-04 T. Chaigne , O. Katz , A. C. Boccara , M. Fink , E. Bossy , S. Gigan

Optical coherence tomography (OCT) is a powerful biomedical imaging technology that relies on the coherent detection of backscattered light to image tissue morphology in vivo. As a consequence, OCT is susceptible to coherent noise (speckle…

Acousto-optical coherence tomography (AOCT) consists in using random phase jumps on ultrasound and light to achieve a millimeter resolution when imaging thick scattering media. We combined this technique with heterodyne off-axis digital…

Optical coherence tomography (OCT) is a high-resolution three-dimensional imaging technique that enables non-destructive measurements of surface and subsurface microstructures. Recent developments of OCT operating in the mid-infrared (MIR)…

Optics · Physics 2020-07-15 Ivan Zorin , Rong Su , Bettina Heise , Bernhard Lendl , Markus Brandstetter

In this chapter a general mathematical model of Optical Coherence Tomography (OCT) is presented on the basis of the electromagnetic theory. OCT produces high resolution images of the inner structure of biological tissues. Images are…

Numerical Analysis · Mathematics 2016-04-19 Peter Elbau , Leonidas Mindrinos , Otmar Scherzer

Imaging with optical resolution through highly scattering media is a long sought-after goal with important applications in deep tissue imaging. Although being the focus of numerous works, this goal was considered impractical until recently.…

Optics · Physics 2012-02-10 Ori Katz , Eran Small , Yaron Silberberg

Optical coherence tomography (OCT) is capable of non-destructively obtaining cross-sectional information of samples with micrometer spatial resolution, which plays an important role in ophthalmology and endovascular medicine. Measuring OCT…

Medical Physics · Physics 2023-11-30 Yang Jianlong , Zhang Haoran , Liu Chang , Gu Chengfu

This paper reports on advances in optical coherence tomography (OCT) for application in dermatology. Full-field OCT is a particular approach of OCT based on white-light interference microscopy. FF-OCT produces en face tomographic images by…

Medical Physics · Physics 2018-04-06 Olivier Levecq , Arthur Davis , Hicham Azimani , David Siret , Jean-Luc Perrot , Arnaud Dubois

Computational corrections of defocus and aberrations in optical coherence tomography (OCT) offers a promising approach to realize high-resolution imaging with deep imaging depth, but without additional high hardware costs. However, these…

Optics · Physics 2025-10-28 Shuichi Makita , Naoki Fukutake , Lida Zhu , Yoshiaki Yasuno

Over the past decade, optical wavefront shaping has been developed to focus light through highly opaque scattering layers, opening new possibilities for biomedical applications. To probe light intensity deep inside soft scattering media…

Optics · Physics 2025-08-25 Fei Xia , Ivo Leite , Robert Prevedel , Thomas Chaigne

This dissertation relates to the transition of the state of the art of swept source optical coherence tomography (SS-OCT) systems to a new realm in which the image acquisition speed is improved by an order of magnitude. With the aid of a…

Image and Video Processing · Electrical Eng. & Systems 2020-02-21 Amir Tofighi Zavareh

Optical Coherence Tomography (OCT) is a key 3D imaging technology that provides micron scale depth resolution for bio-imaging. This resolution substantially surpasses what it typically achieved in Light Detection and Ranging (LiDAR) which…

Optics · Physics 2022-07-27 Robbie Murray , Ashley Lyons
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