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There has been a recent surge of interest in what causes aging. This has been matched by unprecedented research investment in the field from tech companies. But, despite considerable effort from a broad range of researchers, we do not have…
According to GHO (Global Health Observatory (GHO), the high prevalence of a large variety of diseases such as Ischaemic heart disease, stroke, lung cancer disease and lower respiratory infections have remained the top killers during the…
Despite initial success, cancer therapies often fail due to the emergence of drug-resistant cells. In this study, we use a mathematical model to investigate how cancer evolves over time, specifically focusing on the state of the tumor when…
Statements for public health purposes such as "1 in 2 will get cancer by age 85" have appeared in public spaces. The meaning drawn from such statements affects economic welfare, not just public health. Both markets and government use risk…
Lung cancer is one of the death threatening diseases among human beings. Early and accurate detection of lung cancer can increase the survival rate from lung cancer. Computed Tomography (CT) images are commonly used for detecting the lung…
Aging research has produced powerful explanatory frameworks -- evolutionary theories, the Hallmarks of Aging, SENS, geroscience, hyperfunction, and information-loss models -- yet none provides quantitative rules for determining which…
This paper generalizes a previously published differential equation that describes the relation between the age-specific incidence, remission, and mortality of a disease with its prevalence. The underlying model is a simple compartment…
Brain tumor is a life-threatening problem and hampers the normal functioning of the human body. The average five-year relative survival rate for malignant brain tumors is 35.6 percent. For proper diagnosis and efficient treatment planning,…
Abnormal growth of cells in the brain and its surrounding tissues is known as a brain tumor. There are two types, one is benign (non-cancerous) and another is malignant (cancerous) which may cause death. The radiologists' ability to…
The prevalence of dementia is set to explode throughout the 21st century. This trend has already started in developed countries and will continue to place heavy pressures on both public health and social care services across the world. No…
We present a general computational theory of cancer and its developmental dynamics. The theory is based on a theory of the architecture and function of developmental control networks which guide the formation of multicellular organisms.…
Cancer is most commonly viewed as resulting from somatic mutations enhancing proliferation and invasion. Some hypotheses further propose that these new capacities reveal a breakdown of multicellularity allowing cancer cells to escape…
We consider high-dimensional regression over subgroups of observations. Our work is motivated by biomedical problems, where disease subtypes, for example, may differ with respect to underlying regression models, but sample sizes at the…
Despite significant medical advancements, cancer remains the second leading cause of death, with over 600,000 deaths per year in the US. One emerging field, pathway analysis, is promising but still relies on manually derived wet lab data,…
Detecting cancers at early stages can dramatically reduce mortality rates. Therefore, practical cancer screening at the population level is needed. Here, we develop a comprehensive detection system to classify all common cancer types. By…
Adaptive therapy is a recent paradigm in cancer treatment aiming at indefinite, safe containment of the disease when cure is judged unattainable. In modeling this approach, inherent limitations arise due to the structure of the vector…
Cancer remains one of the most challenging diseases to treat in the medical field. Machine learning has enabled in-depth analysis of rich multi-omics profiles and medical imaging for cancer diagnosis and prognosis. Despite these…
Breast cancer research over the last decade has been tremendous. The ground breaking innovations and novel methods help in the early detection, in setting the stages of the therapy and in assessing the response of the patient to the…
As cell proliferation is limited due to the loss of telomere repeats in DNA of normal somatic cells during division, telomere attrition can possibly play an important role in determining the maximum life span of organisms as well as…
The physical idea of the natural origin of diseases and deaths has been presented. The fundamental microscopical reason is the destruction of any metastable state by thermal activation of a nucleus of a nonreversable change. On the basis of…