Related papers: Multiphysics Analysis of the 2.5 MeV BNCT RFQ Acce…
A high-intensity continuous wave (CW) radio frequency quadrupole (RFQ) accelerator is designed for boron neutron capture therapy (BNCT). The transmission efficiency of a 20-mA proton beam accelerated from 30 keV to 2.5 MeV can reach 98.7%…
Boron Neutron Capture Therapy (BNCT) is a neutron radiotherapy used to treat tumours cells previously doping with Boron-10. This therapy requires an epithermal neutron beam for the treatment of deep tumours and a thermal beam for shallow…
Boron Neutron Capture Therapy (BNCT) is a form of radiotherapy based on the irradiation of the tumour with a low energy neutron beam, after the administration of a selective drug enriched in boron-10. The therapy exploits the high cross…
Background and purpose: Accelerator-Based Boron Neutron Capture Therapy is a radiotherapy based on compact accelerator neutron sources requiring an epithermal neutron field for tumour irradiations. Neutrons of 10 keV are considered as the…
Boron Neutron Capture Therapy (BNCT) is an innovative binary form of radiation therapy with high selectivity towards cancer tissue based on the neutron capture reaction 10B(n,$\alpha$)7Li, consisting in the exposition of patients to neutron…
The accurate imaging and quantitative measurement of 478-keV prompt gamma rays are critical for advancing boron neutron capture therapy (BNCT), a promising cancer treatment. Although numerical simulations have indicated that such…
Boron neutron capture therapy (BNCT) leverages the nuclear reaction between thermal neutrons and boron-10 (B-10) atoms to induce selective tumor cell death. The spatial and quantum mechanical overlap between the neutron wavefunction and…
Protontherapy is hadrontherapy fastest-growing modality and a pillar in the battle against cancer. Hadrontherapy superiority lies in its inverted depth-dose profile, hence tumour-confined irradiation. Protons, however, lack distinct…
Bremsstrahlung photon beams produced by medical linear accelerators are currently the most commonly used method of radiation therapy for cancerous tumors. Photons with energies greater than 8-10 MeV potentially generate neutrons through…
This work presents a preliminary evaluation of the use of the convolutional neural network nnU-NET to automatically contour the volume of Glioblastoma Multiforme in medical images of patients. The goal is to assist the preparation of the…
We propose a series of simulations about the potential use of Boron isotopes to trigger neutron-free (aneutronic) nuclear reactions in cancer cells through the interaction with an incoming energetic proton beam, thus resulting in the…
Selective accumulation of B-10 compound in tumour tissue is a fundamental condition for the achievement of BNCT (Boron Neutron Capture Therapy), since the effectiveness of therapy irradiation derives just from neutron capture reaction of…
At the Ibaraki Neutron Medical Research Center, an accelerator-based neutron source for iBNCT (Ibaraki - Boron Neutron Capture Therapy) is being developed using an 8-MeV proton linac and a beryllium-based neutron production target. The…
The $^{10}$B isotope has been almost exclusively used in the neutron-capture radiation therapy (NCT) of cancer for decades. We have identified two other nuclides suitable for the radiotherapy, which have ca.10 times larger cross section of…
The radiofrequency resonant four-quadrant mechanical structure of a 4-vane Radio Frequency Quadrupole (RFQ) has a high quality factor and narrow bandwidth, resulting in high sensitivity to frequency detuning caused by thermal expansion…
Dosimetry in BNCT poses significant challenges due to the indirect effect of neutrons interacting with elements within the body and uncertainties associated with the uptake of boron compounds used in clinical practice. Current treatment…
Boron neutron capture therapy is about a century old, but still current and active. In this treatment, a high absorption cross-section of boron is used for thermal neutrons and the excited state is decomposed into alpha and lithium ions.…
The average Relative Biological effectiveness (RBE) factors for neutron irradiation in the context of a BNCT treatment are studied. This research considers the various interactions and secondary particles of each process and estimates the…
Beam monitoring and evaluation are very important to boron neutron capture therapy (BNCT), and a variety of detectors have been developed for these applications. However, most of the detectors used in BNCT only have a small detection area,…
The goal of this research project is to give quantitative information useful for the design of a g-ray detector to investigate neutron capture (n, g) reactions on radioactive nuclei at the Manuel Lujan Jr. Neutron Scattering Center (MLNSC)…