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We study pairwise Ising models for describing the statistics of multi-neuron spike trains, using data from a simulated cortical network. We explore efficient ways of finding the optimal couplings in these models and examine their…

Quantitative Methods · Quantitative Biology 2009-05-21 Yasser Roudi , Joanna Tyrcha , John Hertz

Predictions for physical systems often rely upon knowledge acquired from ensembles of entities, e.g., ensembles of cells in biological sciences. For qualitative and quantitative analysis, these ensembles are simulated with parametric…

Machine Learning · Statistics 2023-09-28 Timothy Rumbell , Jaimit Parikh , James Kozloski , Viatcheslav Gurev

A common task in experimental sciences is to fit mathematical models to real-world measurements to improve understanding of natural phenomenon (reverse-engineering or inverse modeling). When complex dynamical systems are considered, such as…

Numerical Analysis · Mathematics 2018-06-18 Jean-Charles Croix , Nicolas Durrande , Mauricio Alvarez

Resolving the diffusion coefficient is a key element in many biological and engineering systems, including pharmacological drug transport and fluid mechanics analyses. Additionally, these systems often have spatial variation in the…

Quantitative Methods · Quantitative Biology 2024-03-08 Sukirt Thakur , Ehsan Esmaili , Sarah Libring , Luis Solorio , Arezoo M. Ardekani

Energy landscapes play a crucial role in shaping dynamics of many real-world complex systems. System evolution is often modeled as particles moving on a landscape under the combined effect of energy-driven drift and noise-induced diffusion,…

Computational Engineering, Finance, and Science · Computer Science 2025-03-04 Ruikun Li , Huandong Wang , Qingmin Liao , Yong Li

Integrating heterogeneous data sources and expert knowledge is essential for overcoming data scarcity and enhancing estimation accuracy. Two main frameworks naturally arise to perform the integration of these multiple sources: sequential…

Methodology · Statistics 2025-11-26 Mario Figueira , David Conesa , Antonio López-Quílez , Håvard Rue

Geophysical inverse problems are often ill-posed and admit multiple solutions. Conventional discriminative methods typically yield a single deterministic solution, which fails to model the posterior distribution, cannot generate diverse…

Conventional inverse optimization inputs a solution and finds the parameters of an optimization model that render a given solution optimal. The literature mostly focuses on inferring the objective function in linear problems when accepted…

Optimization and Control · Mathematics 2024-10-10 Houra Mahmoudzadeh , Kimia Ghobadi

A natural way of handling imbalanced data is to attempt to equalise the class frequencies and train the classifier of choice on balanced data. For two-class imbalanced problems, the classification success is typically measured by the…

Computer Vision and Pattern Recognition · Computer Science 2018-04-20 Ludmila I. Kuncheva , Álvar Arnaiz-González , José-Francisco Díez-Pastor , Iain A. D. Gunn

A recent technology breakthrough in spatial molecular profiling has enabled the comprehensive molecular characterizations of single cells while preserving spatial information. It provides new opportunities to delineate how cells from…

Applications · Statistics 2021-10-07 Xi Jiang , Qiwei Li , Guanghua Xiao

We consider the task of learning Ising models when the signs of different random variables are flipped independently with possibly unequal, unknown probabilities. In this paper, we focus on the problem of robust estimation of…

Machine Learning · Statistics 2020-06-11 Ashish Katiyar , Vatsal Shah , Constantine Caramanis

Using methods of statistical physics, we analyse the error of learning couplings in large Ising models from independent data (the inverse Ising problem). We concentrate on learning based on local cost functions, such as the…

Disordered Systems and Neural Networks · Physics 2017-08-02 Ludovica Bachschmid-Romano , Manfred Opper

The Ising and Potts models, among the most important models in statistical physics, have been used for modeling binary and multinomial data on lattices in a wide variety of disciplines such as psychology, image analysis, biology, and…

Methodology · Statistics 2025-09-29 Maria Paula Duenas-Herrera , Stephen Berg , Murali Haran

The forward problems of pattern formation have been greatly empowered by extensive theoretical studies and simulations, however, the inverse problem is less well understood. It remains unclear how accurately one can use images of pattern…

Computational Physics · Physics 2021-04-07 Hongbo Zhao , Richard D. Braatz , Martin Z. Bazant

While machine learning is rapidly being developed and deployed in health settings such as influenza prediction, there are critical challenges in using data from one environment in another due to variability in features; even within disease…

Machine Learning · Statistics 2020-03-10 Vishwali Mhasawade , Nabeel Abdur Rehman , Rumi Chunara

Combining machine learning with econometric analysis is becoming increasingly prevalent in both research and practice. A common empirical strategy involves the application of predictive modeling techniques to 'mine' variables of interest…

Econometrics · Economics 2020-12-22 Mochen Yang , Edward McFowland , Gordon Burtch , Gediminas Adomavicius

The statistical picture of the solution space for a binary perceptron is studied. The binary perceptron learns a random classification of input random patterns by a set of binary synaptic weights. The learning of this network is difficult…

Disordered Systems and Neural Networks · Physics 2013-08-27 Haiping Huang , K. Y. Michael Wong , Yoshiyuki Kabashima

This paper extends the sample complexity theory for ill-posed inverse problems developed in a recent work by the authors [`Compressed sensing for inverse problems and the sample complexity of the sparse Radon transform', J. Eur. Math. Soc.,…

Functional Analysis · Mathematics 2025-01-06 Giovanni S. Alberti , Alessandro Felisi , Matteo Santacesaria , S. Ivan Trapasso

It is known that statistical model selection as well as identification of dynamical equations from available data are both very challenging tasks. Physical systems behave according to their underlying dynamical equations which, in turn, can…

Mathematical Physics · Physics 2017-10-11 Sean Alan Ali , Carlo Cafaro

Nature apparently does a lot of computation constantly. If we can harness some of that computation at an appropriate level, we can potentially perform certain type of computation (much) faster and more efficiently than we can do with a von…

Emerging Technologies · Computer Science 2024-02-21 Uday Kumar Reddy Vengalam , Yongchao Liu , Tong Geng , Hui Wu , Michael Huang