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Retinal degenerative diseases lead to the blindness of millions of people around the world. In case of age-related macular degeneration (AMD), the atrophy of retinal pigment epithelium (RPE) precedes neural dystrophy. But as crucial as…

Retinitis pigmentosa (RP) is a group of inherited degenerative eye diseases characterized by mutations in the genetic structure of the photoreceptors that leads to the premature death of both rod and cone photoreceptors. Defects in…

Quantitative Methods · Quantitative Biology 2012-06-21 Erika T. Camacho , Stephen Wirkus

Retinitis pigmentosa (RP), one of the leading causes of vision loss and blindness globally, is a progressive retinal disease involving the degradation of photoreceptors (7) and/or retinal pigment epithelial cells (14). Affecting…

Medical Physics · Physics 2022-11-10 Rickie Xian

Non-degradable fluorophores that accumulate as Lipofuscin in retinal pigment epithelium (RPE) cells has been a major source of intrinsic biomarker for quantifying the progression of several diseases, including age-related macular…

Biological Physics · Physics 2019-01-25 Suman K. Manna , Pengfei Zhang , Ratheesh K. Meleppat

Ophthalmic images may contain identical-looking pathologies that can cause failure in automated techniques to distinguish different retinal degenerative diseases. Additionally, reliance on large annotated datasets and lack of knowledge…

Image and Video Processing · Electrical Eng. & Systems 2022-08-02 Sharif Amit Kamran , Khondker Fariha Hossain , Alireza Tavakkoli , Stewart Lee Zuckerbrod , Salah A. Baker

Experts use retinal images and vessel trees to detect and diagnose various eye, blood circulation, and brain-related diseases. However, manual segmentation of retinal images is a time-consuming process that requires high expertise and is…

Image and Video Processing · Electrical Eng. & Systems 2023-08-17 Alnur Alimanov , Md Baharul Islam

Retinal vessel segmentation is a fundamental step in screening, diagnosis, and treatment of various cardiovascular and ophthalmic diseases. Robustness is one of the most critical requirements for practical utilization, since the test images…

Image and Video Processing · Electrical Eng. & Systems 2021-09-29 Xu Sun , Huihui Fang , Yehui Yang , Dongwei Zhu , Lei Wang , Junwei Liu , Yanwu Xu

Retinopathy of Prematurity (ROP) is an eye disorder primarily affecting premature infants with lower weights. It causes proliferation of vessels in the retina and could result in vision loss and, eventually, retinal detachment, leading to…

Image and Video Processing · Electrical Eng. & Systems 2020-04-06 Alexander Ding , Qilei Chen , Yu Cao , Benyuan Liu

Subretinal injection is a critical procedure for delivering therapeutic agents to treat retinal diseases such as age-related macular degeneration (AMD). However, retinal motion caused by physiological factors such as respiration and…

Many eye diseases like Diabetic Macular Edema (DME), Age-related Macular Degeneration (AMD), and Glaucoma manifest in the retina, can cause irreversible blindness or severely impair the central version. The Optical Coherence Tomography…

Image and Video Processing · Electrical Eng. & Systems 2023-03-10 Nchongmaje Ndipenoch , Alina Miron , Zidong Wang , Yongmin Li

The segmentation of retinal vessels is of significance for doctors to diagnose the fundus diseases. However, existing methods have various problems in the segmentation of the retinal vessels, such as insufficient segmentation of retinal…

Computer Vision and Pattern Recognition · Computer Science 2018-05-14 Yun Jiang , Ning Tan

Retinal imaging has emerged as a promising method of addressing this challenge, taking advantage of the unique structure of the retina. The retina is an embryonic extension of the central nervous system, providing a direct in vivo window…

Computer Vision and Pattern Recognition · Computer Science 2024-09-24 Syed Javed , Tariq M. Khan , Abdul Qayyum , Arcot Sowmya , Imran Razzak

We use a Convolutional Recurrent Neural Network approach to learn morphological evolution driven by surface diffusion. To this aim we first produce a training set using phase field simulations. Intentionally, we insert in such a set only…

Computational Physics · Physics 2024-05-07 Daniele Lanzoni , Marco Albani , Roberto Bergamaschini , Francesco Montalenti

Retinal degenerative diseases cause profound visual impairment in more than 10 million people worldwide, and retinal prostheses are being developed to restore vision to these individuals. Analogous to cochlear implants, these devices…

Computer Vision and Pattern Recognition · Computer Science 2021-02-02 Nicole Han , Sudhanshu Srivastava , Aiwen Xu , Devi Klein , Michael Beyeler

Medical Imaging is one of the growing fields in the world of computer vision. In this study, we aim to address the Diabetic Retinopathy (DR) problem as one of the open challenges in medical imaging. In this research, we propose a new lesion…

Image and Video Processing · Electrical Eng. & Systems 2021-08-19 Farzan Shenavarmasouleh , Farid Ghareh Mohammadi , M. Hadi Amini , Thiab Taha , Khaled Rasheed , Hamid R. Arabnia

Age-related macular degeneration (AMD) may cause severe loss of vision or blindness particularly in elderly people. Exudative AMD is characterized by angiogenesis of blood vessels growing from underneath the macula, crossing the…

Biological Physics · Physics 2021-04-02 Rocío Vega , Manuel Carretero , Luis L. Bonilla

Retinal vessel segmentation plays an imaportant role in the field of retinal image analysis because changes in retinal vascular structure can aid in the diagnosis of diseases such as hypertension and diabetes. In recent research, numerous…

Image and Video Processing · Electrical Eng. & Systems 2020-04-09 Changlu Guo , Márton Szemenyei , Yugen Yi , Ying Xue , Wei Zhou , Yangyuan Li

The presence of drusen is the main hallmark of early/intermediate age-related macular degeneration (AMD). Therefore, automated drusen segmentation is an important step in image-guided management of AMD. There are two common approaches to…

Image and Video Processing · Electrical Eng. & Systems 2019-12-12 Rhona Asgari , Sebastian Waldstein , Ferdinand Schlanitz , Magdalena Baratsits , Ursula Schmidt-Erfurth , Hrvoje Bogunović

Medicines and agricultural biocides are often discovered using large phenotypic screens across hundreds of compounds, where visible effects of whole organisms are compared to gauge efficacy and possible modes of action. However, such…

Biological Physics · Physics 2022-01-19 Henry Cavanagh , Andreas Mosbach , Gabriel Scalliet , Rob Lind , Robert G. Endres

Purpose - To develop and validate a deep learning (DL) framework for the detection and quantification of drusen and reticular pseudodrusen (RPD) on optical coherence tomography scans. Design - Development and validation of deep learning…

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