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Biological systems are governed by structured molecular interactions, where pathways, regulatory circuits, and functional gene relationships shape cellular behavior and disease progression. Much of this knowledge is naturally represented as…

Machine Learning · Computer Science 2026-05-26 Yuwei Xue , Sakib Mostafa , James Zou , Joseph Liao , Maximilian Diehn , Ash A. Alizadeh , Lei Xing , Md. Tauhidul Islam

Disease-gene prediction (DGP) refers to the computational challenge of predicting associations between genes and diseases. Effective solutions to the DGP problem have the potential to accelerate the therapeutic development pipeline at early…

Machine Learning · Computer Science 2019-07-15 Vikash Singh , Pietro Lio'

Synthetic data can be used in various applications, such as correcting bias datasets or replacing scarce original data for simulation purposes. Generative Adversarial Networks (GANs) are considered state-of-the-art for developing generative…

Machine Learning · Computer Science 2022-03-08 Gael Lederrey , Tim Hillel , Michel Bierlaire

Directed acyclic graph (DAG) tasks are currently adopted in the real-time domain to model complex applications from the automotive, avionics, and industrial domains that implement their functionalities through chains of intercommunicating…

Machine Learning · Computer Science 2024-01-12 Binqi Sun , Mirco Theile , Ziyuan Qin , Daniele Bernardini , Debayan Roy , Andrea Bastoni , Marco Caccamo

Transcriptional regulation of gene expression is one of the main processes that affect cell diversification from a single set of genes. Regulatory proteins often interact with DNA regions located distally from the transcription start sites…

Genomics · Quantitative Biology 2014-04-30 Sofie Demeyer , Tom Michoel

A common theme in causal inference is learning causal relationships between observed variables, also known as causal discovery. This is usually a daunting task, given the large number of candidate causal graphs and the combinatorial nature…

Machine Learning · Statistics 2022-10-11 Romain Lopez , Jan-Christian Hütter , Jonathan K. Pritchard , Aviv Regev

Directed acyclic graphs (DAGs) serve as crucial data representations in domains such as hardware synthesis and compiler/program optimization for computing systems. DAG generative models facilitate the creation of synthetic DAGs, which can…

Machine Learning · Computer Science 2025-03-04 Mufei Li , Viraj Shitole , Eli Chien , Changhai Man , Zhaodong Wang , Srinivas Sridharan , Ying Zhang , Tushar Krishna , Pan Li

Directed acyclic graphs (DAGs) constitute a central modeling tool to enable principled reasoning about cause-effect interactions in complex systems. However, since the causal structure underlying a group of variables is often unknown and…

Machine Learning · Statistics 2026-05-25 Gonzalo Mateos , Samuel Rey , Hamed Ajorlou , Mariano Tepper

Generating realistic graph-structured data is challenging due to discrete connectivity, varying graph sizes, and class-specific structural patterns. Recent Generative Adversarial Networks (GAN)-based graph generation methods improve edge…

Machine Learning · Computer Science 2026-05-29 James Sargant , Seyedeh Ava Razi Razavi , Renata Dividino , Sheridan Houghten

Bayesian networks, with structure given by a directed acyclic graph (DAG), are a popular class of graphical models. However, learning Bayesian networks from discrete or categorical data is particularly challenging, due to the large…

Methodology · Statistics 2018-02-06 Jiaying Gu , Fei Fu , Qing Zhou

Directed acyclic graphs (DAGs) and associated probability models are widely used to model neural connectivity and communication channels. In many experiments, data are collected from multiple subjects whose connectivities may differ but are…

Methodology · Statistics 2014-11-17 Chris J. Oates , Lilia Carneiro da Costa , Tom Nichols

Latent representations of drugs and their targets produced by contemporary graph autoencoder-based models have proved useful in predicting many types of node-pair interactions on large networks, including drug-drug, drug-target, and…

Biomolecules · Quantitative Biology 2022-11-01 Nhat Khang Ngo , Truong Son Hy , Risi Kondor

We consider the problem of learning causal Directed Acyclic Graphs (DAGs) using combinations of observational and interventional experimental data. Current methods tailored to this setting assume that interventions either destroy…

Methodology · Statistics 2023-12-04 Alessandro Mascaro , Federico Castelletti

Seismic phase association connects earthquake arrival time measurements to their causative sources. Effective association must determine the number of discrete events, their location and origin times, and it must differentiate real arrivals…

Geophysics · Physics 2023-01-18 Ian W. McBrearty , Gregory C. Beroza

The causal dependence in data is often characterized by Directed Acyclic Graphical (DAG) models, widely used in many areas. Causal discovery aims to recover the DAG structure using observational data. This paper focuses on causal discovery…

Machine Learning · Computer Science 2024-06-12 Boxin Zhao , Weishi Wang , Dingyuan Zhu , Ziqi Liu , Dong Wang , Zhiqiang Zhang , Jun Zhou , Mladen Kolar

It is becoming increasingly clear that complex interactions among genes and environmental factors play crucial roles in triggering complex diseases. Thus, understanding such interactions is vital, which is possible only through statistical…

Applications · Statistics 2020-05-04 Durba Bhattacharya , Sourabh Bhattacharya

In this article, the optimal sample complexity of learning the underlying interactions or dependencies of a Linear Dynamical System (LDS) over a Directed Acyclic Graph (DAG) is studied. We call such a DAG underlying an LDS as dynamical DAG…

Machine Learning · Statistics 2024-04-02 Mishfad Shaikh Veedu , Deepjyoti Deka , Murti V. Salapaka

Complex dynamical systems are often modeled as networks, with nodes representing dynamical units which interact through the network's links. Gene regulatory networks, responsible for the production of proteins inside a cell, are an example…

Statistical Mechanics · Physics 2009-09-30 Zoran Levnajić

Causal discovery of genome-scale networks is important for identifying pathways from genes to observable traits - e.g. differences in cell function, disease, drug resistance and others. Causal learners based on graphical models rely on…

Molecular Networks · Quantitative Biology 2023-04-07 Ashka Shah , Arvind Ramanathan , Valerie Hayot-Sasson , Rick Stevens

This paper deals with the design of Excitation and Measurement Patterns (EMP) for the identification of a class of dynamical networks whose topology has the structure of a Directed Acyclic Graph (DAG). In addition to the by now well known…

Systems and Control · Electrical Eng. & Systems 2022-04-01 Eduardo Mapurunga , Michel Gevers , Alexandre S. Bazanella