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High resolution transcranial ultrasound imaging in humans has been a persistent challenge for ultrasound due to the imaging degradation effects from aberration and reverberation. These mechanisms depend strongly on skull morphology and they…

Medical Physics · Physics 2018-11-28 Danai E. Soulioti , David Espíndola , Paul A. Dayton , Gianmarco Pinton

This paper describes an x-ray microtomographic technique for imaging the three-dimensional structure of the human cerebral cortex. Neurons in the brain constitute a neural circuit as a three-dimensional network. The brain tissue is composed…

Progress in high-resolution x-ray microtomography has provided us with a practical approach to determining three-dimensional (3D) structures of opaque samples at micrometer to submicrometer resolution. In this review, we give an…

Biological Physics · Physics 2016-09-09 Ryuta Mizutani , Yoshio Suzuki

Methods for resolving the 3D microstructure of the brain typically start by thinly slicing and staining the brain, and then imaging each individual section with visible light photons or electrons. In contrast, X-rays can be used to image…

We demonstrate a neutron tomography technique with sub-micrometer spatial resolution. Our method consists of measuring neutron diffraction spectra using a double crystal diffractometer as a function of sample rotation and then using a phase…

Instrumentation and Detectors · Physics 2020-11-13 B. Heacock , D. Sarenac , D. G. Cory , M. G. Huber , J. P. W. MacLean , H. Miao , H. Wen , D. A. Pushin

A software for processing sets of full-color images of biological tissue histological sections is developed. We used histological sections obtained by the method of high-precision layer-by-layer grinding of frozen biological tissues. The…

This article addresses gaps in definitions and a lack of standard measurement techniques to assess the spatial resolution in atom probe tomography. This resolution is known to be anisotropic, being better in the depth than laterally.…

We introduce the concept of computerized tomographic microscopy in magnetic resonance imaging using the magnetic fields and field gradients from a ferromagnetic probe. We investigate a configuration where a two-dimensional sample is under…

Instrumentation and Detectors · Physics 2009-11-10 Mladen Barbic , Axel Scherer

This paper presents a method for estimating the resolution of a digital holographic microscope using neural network analysis of reconstructed images. The spectral bandwidth of the source ($\Delta \lambda$) is used as a controlled image…

Optics · Physics 2026-05-12 A. G. Fedorov

Atomic resolution imaging is demonstrated using a hybrid scanning tunneling/near-field microwave microscope (microwave-STM). The microwave channels of the microscope correspond to the resonant frequency and quality factor of a coaxial…

Mesoscale and Nanoscale Physics · Physics 2011-08-16 Jonghee Lee , Christian J. Long , Haitao Yang , Xiao-Dong Xiang , Ichiro Takeuchi

The purpose of this study is to enable in-vivo three-dimensional (3-D) ultrasound localization microscopy (ULM) of posterior ocular microvasculature using a 256-channel system and a 1024-element matrix array, and to overcome limitations of…

Synchrotron radiation-based X-ray microtomography is uniquely suited for post mortem three-dimensional visualization of organs such as the mouse brain. Tomographic imaging of the entire mouse brain with isotropic cellular resolution…

Recent research has explored using neural networks to reconstruct undersampled magnetic resonance imaging (MRI) data. Because of the complexity of the artifacts in the reconstructed images, there is a need to develop task-based approaches…

Image and Video Processing · Electrical Eng. & Systems 2022-10-25 Joshua D. Herman , Rachel E. Roca , Alexandra G. O'Neill , Marcus L. Wong , Sajan G. Lingala , Angel R. Pineda

With the advent of microsphere assisted microscopy in 2011, this technique emerged as a simple and easy way to obtain optical super-resolution. Although the possible mechanisms of imaging by microspheres are debated in the literature, most…

Optics · Physics 2015-08-27 Navid Farahi

We present the first three-dimensional theoretical model of microparticle-assisted super-resolution imaging, enabling accurate simulation of virtual image formation. The model reveals that accounting for partial spatial coherence of…

Diffusion magnetic resonance imaging (dMRI) is a crucial non-invasive technique for exploring the microstructure of the living human brain. Traditional hand-crafted and model-based tissue microstructure reconstruction methods often require…

Image and Video Processing · Electrical Eng. & Systems 2025-02-26 Xinrui Ma , Jian Cheng , Wenxin Fan , Ruoyou Wu , Yongquan Ye , Shanshan Wang

Comprehensive, synapse-resolution imaging of the brain will be crucial for understanding neuronal computations and function. In connectomics, this has been the sole purview of volume electron microscopy (EM), which entails an excruciatingly…

Image and Video Processing · Electrical Eng. & Systems 2023-03-03 Yicong Li , Yaron Meirovitch , Aaron T. Kuan , Jasper S. Phelps , Alexandra Pacureanu , Wei-Chung Allen Lee , Nir Shavit , Lu Mi

Diffraction analysis in four dimensional scanning transmission electron microscopy now enables the mapping of local structures including symmetry, strain, and polarization of materials. However, measuring the distribution of these…

Materials Science · Physics 2024-06-19 Tim B. Eldred , Jacob G. Smith , Wenpei Gao

A central problem in neuroscience is reconstructing neuronal circuits on the synapse level. Due to a wide range of scales in brain architecture such reconstruction requires imaging that is both high-resolution and high-throughput. Existing…

Computer Vision and Pattern Recognition · Computer Science 2012-10-03 Tao Hu , Juan Nunez-Iglesias , Shiv Vitaladevuni , Lou Scheffer , Shan Xu , Mehdi Bolorizadeh , Harald Hess , Richard Fetter , Dmitri Chklovskii

Super-resolution is a machine-learning technique in image processing which generates high-resolution images from low-resolution images. Inspired by this approach, we perform a numerical experiment of quantum machine learning, which takes…

Quantum Physics · Physics 2022-11-09 Rei Sakuma , Yutaro Iiyama , Lento Nagano , Ryu Sawada , Koji Terashi
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