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Irregularly sampled time series data are common in a variety of fields. Many typical methods for drawing insight from data fail in this case. Here we attempt to generalize methods for clustering trajectories to irregularly and sparsely…

Quantitative Methods · Quantitative Biology 2021-09-01 Gary K. Nave , Swati Padhee , Amanuel Alambo , Tanvi Banerjee , Nirmish Shah , Daniel M. Abrams

Cluster analysis aims at separating patients into phenotypically heterogenous groups and defining therapeutically homogeneous patient subclasses. It is an important approach in data-driven disease classification and subtyping. Acute…

Quantitative Methods · Quantitative Biology 2019-03-28 Eryu Xia , Xin Du , Jing Mei , Wen Sun , Suijun Tong , Zhiqing Kang , Jian Sheng , Jian Li , Changsheng Ma , Jianzeng Dong , Shaochun Li

The SYNTAX score has become a widely used measure of coronary disease severity, crucial in selecting the optimal mode of the revascularization procedure. This paper introduces a new medical regression and classification problem -…

Computer Vision and Pattern Recognition · Computer Science 2025-05-07 Alexander Ponomarchuk , Ivan Kruzhilov , Galina Zubkova , Artem Shadrin , Ruslan Utegenov , Ivan Bessonov , Pavel Blinov

This article contributes to the search for a notion of postural style, focusing on the issue of classifying subjects in terms of how they maintain posture. Longer term, the hope is to make it possible to determine on a case by case basis…

Applications · Statistics 2012-09-28 Antoine Chambaz , Christophe Denis

Objective: Sepsis is one of the most serious hospital conditions associated with high mortality. Sepsis is the result of a dysregulated immune response to infection that can lead to multiple organ dysfunction and death. Due to the wide…

At present, the vast majority of human subjects with neurological disease are still diagnosed through in-person assessments and qualitative analysis of patient data. In this paper, we propose to use Topological Data Analysis (TDA) together…

Machine Learning · Computer Science 2020-05-07 Afra Nawar , Farhan Rahman , Narayanan Krishnamurthi , Anirudh Som , Pavan Turaga

Epilepsy is a common neurological disorder characterized by abrupt seizures. Although seizures may appear random, they are often preceded by early warning signs in neural signals, notably, critical slowing down, a phenomenon in which the…

Systems and Control · Electrical Eng. & Systems 2024-11-12 Yuzhen Qin , Marcel van Gerven

The identification of phenotypes within complex diseases or syndromes is a fundamental component of precision medicine, which aims to adapt healthcare to individual patient characteristics. Postoperative delirium (POD) is a complex…

We introduce an entropy-based classification method for pairs of sequences (ECPS) for quantifying mutual dependencies in heart rate and beat-to-beat blood pressure recordings. The purpose of the method is to build a classifier for data in…

Diagnosis of Parkinson's disease (PD) is commonly based on medical observations and assessment of clinical signs, including the characterization of a variety of motor symptoms. However, traditional diagnostic approaches may suffer from…

Machine Learning · Computer Science 2020-10-14 Jie Mei , Christian Desrosiers , Johannes Frasnelli

Parkinson's disease (PD) is a progressive neurodegenerative disorder that results in a variety of motor dysfunction symptoms, including tremors, bradykinesia, rigidity and postural instability. The diagnosis of PD mainly relies on clinical…

Computer Vision and Pattern Recognition · Computer Science 2022-07-15 Haozheng Zhang , Edmond S. L. Ho , Xiatian Zhang , Hubert P. H. Shum

Understanding how the brain switches from normal activity to an epileptic seizure is essential for improving seizure therapy, yet the underlying mechanisms remain largely unknown. In particular, seizure onset can be described as a critical…

Parkinson's disease (PD) is a progressive disorder in which symptom burden and functional impairment evolve over time, making severity staging essential for clinical monitoring and treatment planning. However, many computational studies…

Machine Learning · Computer Science 2026-04-21 Md Mezbahul Islam , John Michael Templeton , Christian Poellabauer , Ananda Mohan Mondal

Patient subtyping based on temporal observations can lead to significantly nuanced subtyping that acknowledges the dynamic characteristics of diseases. Existing methods for subtyping trajectories treat the evolution of clinical observations…

Machine Learning · Computer Science 2018-11-30 Nikhil Galagali , Minnan Xu-Wilson

The technical capacity to monitor patients with a mobile device has drastically expanded, but data produced from this approach are often difficult to interpret. We present a solution to produce a meaningful representation of patient status…

The goal is to develop a novel approach for cardiac disease prediction and diagnosis using intelligent agents. Initially the symptoms are preprocessed using filter and wrapper based agents. The filter removes the missing or irrelevant…

Multiagent Systems · Computer Science 2010-09-28 Murugesan Kuttikrishnan

Epilepsy is a well-known neuronal disorder that can be identified by interpretation of the electroencephalogram (EEG) signal. Usually, the length of an EEG signal is quite long which is challenging to interpret manually. In this work, we…

Machine Learning · Computer Science 2019-03-07 Md Mursalin , Syed Shamsul Islam , Md Kislu Noman , Adel Ali Al-Jumaily

Identifying the onset of emotional stress in older patients with mood disorders and chronic pain is crucial in mental health studies. To this end, studying the associations between passively sensed variables that measure human behaviors and…

Methodology · Statistics 2025-11-11 Younghoon Kim , Sumanta Basu , Samprit Banerjee

In psychiatric diagnosis, a contemporary data-driven, manual-based method for mental disorders classification is the most popular technique; however, it has several inevitable flaws. Using the three-way decision as a framework, we propose a…

Artificial Intelligence · Computer Science 2023-04-11 Huidong Wang , Md Sakib Ullah Sourav , Mengdi Yang , Jiaping Zhang

Trace clustering has increasingly been applied to find homogenous process executions. However, current techniques have difficulties in finding a meaningful and insightful clustering of patients on the basis of healthcare data. The resulting…

Databases · Computer Science 2020-01-13 Xixi Lu , Seyed Amin Tabatabaei , Mark Hoogendoorn , Hajo A. Reijers
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