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Networks of filamentous proteins play a crucial role in cell mechanics. These cytoskeletal networks, together with various crosslinking and other associated proteins largely determine the (visco)elastic response of cells. In this letter we…

Disordered Systems and Neural Networks · Physics 2009-11-10 D. A. Head , A. J. Levine , F. C. MacKintosh

Disordered athermal biopolymer materials, such as collagen networks that constitute a major component in extracellular matrices and various connective tissues, are initially soft and compliant but stiffen dramatically under strain. Such…

Soft Condensed Matter · Physics 2025-09-19 Zibin Zhang , Eran Bouchbinder , Edan Lerner

Much of our understanding of complex structures is based on simplification: for example, metal-organic frameworks are often discussed in the context of "nodes" and "linkers", allowing for a qualitative comparison with simpler inorganic…

Materials Science · Physics 2020-05-21 Thomas C. Nicholas , Andrew L. Goodwin , Volker L. Deringer

Star polymer is a typical nonlinear macromolecule possessing special thermodynamic behaviors for the existence of a jointing point. The thermodynamic transitions of a single star polymer are systematically studied with bond fluctuation…

Soft Condensed Matter · Physics 2015-05-27 Zilu Wang , Xuehao He

Polymer-grafted nanoparticles (PGNPs) can provide property profiles than cannot be obtained individually by polymers or nanoparticles (NPs). Here, we have studied the mixing--demixing transition of symmetric copolymer melts of…

Soft Condensed Matter · Physics 2020-01-23 Peter Yatsyshin , Nikolaos G. Fytas , Panagiotis E. Theodorakis

Multiscale molecular modeling is widely applied in scientific research of molecular properties over large time and length scales. Two specific challenges are commonly present in multiscale modeling, provided that information between the…

Computational Physics · Physics 2024-07-23 Jun Zhang , Xiaohan Lin , Weinan E , Yi Qin Gao

The properties of polymer liquids on hard and soft substrates are investigated by molecular dynamics simulation of a coarse-grained bead-spring model and dynamic single-chain-in-mean-field (SCMF) simulations of a soft, coarse-grained…

Soft Condensed Matter · Physics 2015-05-18 F. Léonforte , J. Servantie , C. Pastorino , M. Müller

Elastic network models, simple structure-based representations of biomolecules where atoms interact via short-range harmonic potentials, provide great insight into a molecule's internal dynamics and mechanical properties at extremely low…

Soft Condensed Matter · Physics 2018-12-12 Patrick Diggins , Changjiang Liu , Markus Deserno , Raffaello Potestio

Structural and thermodynamic consistency of coarse-graining models across multiple length scales is essential for the predictive role of multi-scale modeling and molecular dynamic simulations that use mesoscale descriptions. Our approach is…

Soft Condensed Matter · Physics 2014-07-04 J. McCarty , A. J. Clark , J. Copperman , M. G. Guenza

The conformational behavior of a coarse-grained finite polymer chain near an attractive spherical surface was investigated by means of multicanonical Monte Carlo computer simulations. In a detailed analysis of canonical equilibrium data…

Soft Condensed Matter · Physics 2018-01-03 Handan Arkin , Wolfhard Janke

We have used kinetic Monte Carlo simulations to study the kinetics of unfolding of cross-linked polymer chains under mechanical loading. As the ends of a chain are pulled apart, the force transmitted by each crosslink increases until it…

Biological Physics · Physics 2009-11-10 Kilho Eom , Dmitrii E Makarov , Gregory J. Rodin

Mesh-like structures, such as mucus gel or cytoskeleton networks, are ubiquitous in biological systems. These intricate structures are composed of cross-linked, semi-flexible bio-filaments, crucial to numerous biological processes. In many…

Soft Condensed Matter · Physics 2024-01-10 Yeongjin Kim , Won Kyu Kim , Jae-Hyung Jeon

We analyse scaling laws that govern macromolecules of different topology: polymer chains, homogeneous and miktoarm star polymers in a good solvent possibly constrained by a porous medium. The latter is modelled by long-range-correlated…

Soft Condensed Matter · Physics 2015-05-13 V. Blavatska , C. von Ferber , Yu. Holovatch

Despite their prevalence, deep networks are poorly understood. This is due, at least in part, to their highly parameterized nature. As such, while certain structures have been found to work better than others, the significance of a model's…

Computer Vision and Pattern Recognition · Computer Science 2018-03-23 Theodore S. Nowak , Jason J. Corso

Layered neural networks have greatly improved the performance of various applications including image processing, speech recognition, natural language processing, and bioinformatics. However, it is still difficult to discover or interpret…

Machine Learning · Statistics 2017-10-05 Chihiro Watanabe , Kaoru Hiramatsu , Kunio Kashino

Mesoscale behavior of polymers is frequently described by universal laws. This physical property motivates us to propose a new modeling concept, grouping polymers into classes with a common long-wavelength representation. In the same class…

Soft Condensed Matter · Physics 2016-10-25 Guojie Zhang , Torsten Stuehn , Kostas Ch. Daoulas , Kurt Kremer

Indentation is a common experimental technique to study the mechanics of polymeric materials. The main advantage of using indentation is because this provides a direct correlation between the microstructure and the small-scale mechanical…

Soft Condensed Matter · Physics 2022-07-20 Manoj Kumar Maurya , Céline Ruscher , Debashish Mukherji , Manjesh Kumar Singh

Transient bonds between fast linkers and slower particles are widespread in physical and biological systems. In spite of their diverse structure and function, a commonality is that the linkers diffuse on timescales much faster compared to…

Soft Condensed Matter · Physics 2023-06-06 Sophie Marbach , Christopher E. Miles

The dynamics of star polymers has been investigated via extensive Molecular- and Brownian Dynamics simulations for a large range of functionality $f$ and packing fraction $\eta$. The calculated isodiffusivity curves display both minima and…

Soft Condensed Matter · Physics 2009-11-10 G. Foffi , F. Sciortino , P. Tartaglia , E. Zaccarelli , F. Lo Verso , L. Reatto , K . A. Dawson , C. N. Likos

We derive the short distance interaction of star polymers in a colloidal solution. We calculate the corresponding force between two stars with arbitrary numbers of legs f_1 and f_2. We show that a simple scaling theory originally derived…

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