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Single-particle cryo-electron microscopy (cryo-EM) has become a cornerstone of structural biology, enabling near-atomic resolution analysis of macromolecules through advanced computational methods. However, the development of cryo-EM…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Runmin Jiang , Genpei Zhang , Yuntian Yang , Siqi Wu , Minhao Wu , Wanyue Feng , Yizhou Zhao , Xi Xiao , Xiao Wang , Tianyang Wang , Xingjian Li , Muyuan Chen , Min Xu

Recently, sparsity-based algorithms are proposed for super-resolution spectrum estimation. However, to achieve adequately high resolution in real-world signal analysis, the dictionary atoms have to be close to each other in frequency,…

Machine Learning · Statistics 2015-06-05 Yiyuan She , Huanghuang Li , Jiangping Wang , Dapeng Wu

Cryo-electron microscopy (cryo-EM) is a powerful technique in structural biology and drug discovery, enabling the study of biomolecules at high resolution. Significant advancements by structural biologists using cryo-EM have led to the…

Biomolecules · Quantitative Biology 2024-12-05 Yi Zhou , Yilai Li , Jing Yuan , Quanquan Gu

In many high-impact applications, it is important to ensure the quality of output of a machine learning algorithm as well as its reliability in comparison with the complexity of the algorithm used. In this paper, we have initiated a…

Machine Learning · Computer Science 2023-03-03 Katarina Doctor , Tong Mao , Hrushikesh Mhaskar

Single particle electron cryomicroscopy (cryo-EM) allows for structures of proteins and protein complexes to be determined from images of non-crystalline specimens. Cryo-EM data analysis requires electron microscope images of randomly…

Instrumentation and Detectors · Physics 2015-11-23 Jianhua Zhao , Marcus A. Brubaker , Samir Benlekbir , John L. Rubinstein

Heterogeneous data pose serious challenges to data analysis tasks, including exploration and visualization. Current techniques often utilize dimensionality reductions, aggregation, or conversion to numerical values to analyze heterogeneous…

Graphics · Computer Science 2017-10-10 Mahsa Mirzargar , Ross T. Whitaker , Robert M. Kirby

Many data sets contain an inherent multilevel structure, for example, because of repeated measurements of the same observational units. Taking this structure into account is critical for the accuracy and calibration of any statistical…

Methodology · Statistics 2020-05-07 Topi Paananen , Alejandro Catalina , Paul-Christian Bürkner , Aki Vehtari

The aim of this work is the numerical homogenization of a parabolic problem with several time and spatial scales using the heterogeneous multiscale method. We replace the actual cell problem with an alternate one, using Dirichlet boundary…

Numerical Analysis · Mathematics 2022-10-11 Daniel Eckhardt , Barbara Verfürth

Meta-learning has been proposed as a promising machine learning topic in recent years, with important applications to image classification, robotics, computer games, and control systems. In this paper, we study the problem of using…

Systems and Control · Electrical Eng. & Systems 2024-05-28 Yunian Pan , Quanyan Zhu

Microorganisms play a vital role in human life. Therefore, microorganism detection is of great significance to human beings. However, the traditional manual microscopic detection methods have the disadvantages of long detection cycle, low…

Computer Vision and Pattern Recognition · Computer Science 2022-04-12 Pingli Ma , Chen Li , Md Mamunur Rahaman , Yudong Yao , Jiawei Zhang , Shuojia Zou , Xin Zhao , Marcin Grzegorzek

Exploration of task mappings plays a crucial role in achieving high performance in heterogeneous multi-processor system-on-chip (MPSoC) platforms. The problem of optimally mapping a set of tasks onto a set of given heterogeneous processors…

Performance · Computer Science 2014-07-01 Wei Quan , Andy D. Pimentel

The analysis of digital images using homological procedures is an outstanding topic in the area of Computational Algebraic Topology. In this paper, we describe a certified reduction strategy to deal with digital images, but preserving their…

Logic in Computer Science · Computer Science 2016-08-11 María Poza , César Domínguez , Jónathan Heras , Julio Rubio

As the particle physics community needs higher and higher precisions in order to test our current model of the subatomic world, larger and larger datasets are necessary. With upgrades scheduled for the detectors of colliding-beam…

Data Analysis, Statistics and Probability · Physics 2025-09-09 Fotis I. Giasemis

The classification of multi-class microarray datasets is a hard task because of the small samples size in each class and the heavy overlaps among classes. To effectively solve these problems, we propose novel Error Correcting Output Code…

Machine Learning · Computer Science 2018-07-10 Mengxin Sun , Kunhong Liu , Qingqi Hong , Beizhan Wang

Cryo-electron microscopy (cryo-EM) enables single-particle analysis of biological macromolecules under strict low-dose imaging conditions, but the resulting micrographs often exhibit extremely low signal-to-noise ratios and weak particle…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Xiaoqi Wu , Xueying Zhan , Wen Li , Junhao Wu , Xin Huang , Min Xu

We propose a general alternating minimization algorithm for nonconvex optimization problems with separable structure and nonconvex coupling between blocks of variables. To fix our ideas, we apply the methodology to the problem of blind…

Optimization and Control · Mathematics 2018-02-07 Robert Hesse , D. Russell Luke , Shoham Sabach , Matthew K. Tam

We present a new theoretical and numerical assessment methodology for a one-dimensional process chain with general applicability to management problems such as the optimization of decision chains or production chains. The process is thereby…

Economics · Quantitative Finance 2017-12-04 Johannes Freiesleben , Nicolas Guérin

Intense short-wavelength pulses from free-electron lasers and high-harmonic-generation sources enable diffractive imaging of individual nano-sized objects with a single x-ray laser shot. The enormous data sets with up to several million…

We introduce the notion of heterogeneous calibration that applies a post-hoc model-agnostic transformation to model outputs for improving AUC performance on binary classification tasks. We consider overconfident models, whose performance is…

Machine Learning · Statistics 2022-02-11 David Durfee , Aman Gupta , Kinjal Basu

Homogenisation empowers the efficient macroscale system level prediction of physical scenarios with intricate microscale structures. Here we develop an innovative powerful, rigorous and flexible framework for asymptotic homogenisation of…

Dynamical Systems · Mathematics 2025-04-08 A. J. Roberts
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