Related papers: Allometric scaling in-vitro
Periodicity in population dynamics is a fundamental issue. In addition to current species-specific analyses, allometry facilitates understanding of limit cycles amongst different species. So far, body-size regressions have been derived for…
Cell growth in size is a complex process coordinated by intrinsic and environmental signals. In a recent work [Tzur et al., Science, 2009, 325:167-171], size distributions in an exponentially growing population of mammalian cells were used…
Segregation of different cell types is a crucial process for the pattern formation in tissues, in particular during embryogenesis. Since the involved cell interactions are complex and difficult to measure individually in experiments,…
The importance of molecular-scale forces in sculpting biological form and function has been acknowledged for more than a century. Accounting for forces in biology is a problem that lies at the intersection of soft condensed matter physics,…
A biophysical issue how the nuclear size dynamically scales with the cellular size remains mysterious. We develop a theoretical framework in which the interactions between polydisperse biomolecules and the mechanical elasticity of the cell…
The competition between non-Hermitian skin effect and Anderson localization leads to various intriguing phenomena concerning spectrums and wavefunctions. Here, we study the linear response of disordered non-Hermitian systems, which is…
In a cell or microorganism the processes that generate mass, energy, information transfer, and cell fate specification are seamlessly integrated through a complex network of various cellular constituents and reactions. However, despite the…
Most organisms grow according to simple laws, which in principle can be derived from energy conservation and scaling arguments, critically dependent on the relation between the metabolic rate B of energy flow and the organism mass m.…
Our aim is to provide an overview of half-saturation constants reported in literature and to explore their consistency with body size. In many ecological models, intake of nutrients by plants and consumption of food by animals is considered…
Natural selection has produced an extraordinary diversity of life histories spanning many orders of magnitude in body size, vital rates, and biological times. In general, big and cold organisms grow and reproduce slowly and live long lives;…
Scientists have long sought to understand how vascular networks supply blood and oxygen to cells throughout the body. Recent work focuses on principles that constrain how vessel size changes through branching generations from the aorta to…
The spatial structure of the cell is highly organized at all levels: from small complexes and assemblies, to local nano- and micro-clusters, to global, micrometer scales across and between cells. We suggest that this multiscale spatial cell…
Swimming is ubiquitous in nature and crucial for the survival of a wide range of organisms. The physics of swimming at the viscosity-dominated microscale and inertia-dominated macroscale is well studied. However, in between lies a…
Two basic features of assemblages of unicellular plankton: (1) their high biodiversity and (2) the power-law structure of their abundance, can be explained by an allometric scaling of cell growth and mortality with respect to cell size. To…
Micro-calorimetry offers significant potential as a quantitative method for studying the structure and function of biological systems, for instance, by probing the excess heat released by cellular or sub-cellular structures, isothermal or…
In earlier work, we introduced a discrete Fibonacci-based ontogenetic model in which the metabolic scaling exponent $b(n)$ is treated as a dynamic function of an organism's developmental stage, and we estimated $b(n)$ for selected mammalian…
The universal scaling law of cortical morphology describes cortical folding as the covariance of average grey matter thickness, pial surface area, and exposed surface area. It applies for mammalian species, humans, and across lobes, however…
In stable environments, cell size fluctuations are thought to be governed by simple physical principles, as suggested by recent findings of scaling properties. Here, by developing a microfluidic device and using E. coli, we investigate the…
The Keller-Segel model is a system of partial differential equations modelling chemotactic aggregation in cellular systems. This model has blowing up solutions for large enough initial conditions in dimensions d >= 2, but all the solutions…
Meaningful laws of nature must be independent of the units employed to measure the variables. The principle of similitude (Rayleigh 1915) or dimensional homogeneity, states that only commensurable quantities (ones having the same dimension)…