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Rooted phylogenetic networks are used by biologists to infer and represent complex evolutionary relationships between species that cannot be accurately explained by a phylogenetic tree. Tree-child networks are a particular class of rooted…

Combinatorics · Mathematics 2024-09-02 Janosch Döcker , Simone Linz

In this paper, we present a survey of the use of graph theoretical techniques in Biology. In particular, we discuss recent work on identifying and modelling the structure of bio-molecular networks, as well as the application of centrality…

Molecular Networks · Quantitative Biology 2007-05-23 Oliver Mason , Mark Verwoerd

Graph structured data are abundant in the real world. Among different graph types, directed acyclic graphs (DAGs) are of particular interest to machine learning researchers, as many machine learning models are realized as computations on…

Machine Learning · Computer Science 2019-10-30 Muhan Zhang , Shali Jiang , Zhicheng Cui , Roman Garnett , Yixin Chen

Biomedical networks (or graphs) are universal descriptors for systems of interacting elements, from molecular interactions and disease co-morbidity to healthcare systems and scientific knowledge. Advances in artificial intelligence,…

Machine Learning · Computer Science 2025-02-07 Michelle M. Li , Kexin Huang , Marinka Zitnik

Phylogenetic networks are rooted, labelled directed acyclic graphs which are commonly used to represent reticulate evolution. There is a close relationship between phylogenetic networks and multi-labelled trees (MUL-trees). Indeed, any…

Populations and Evolution · Quantitative Biology 2015-06-16 Katharina T. Huber , Vincent Moulton , Mike Steel , Taoyang Wu

Maximal Ancestral Graphs (MAGs) provide an abstract representation of Directed Acyclic Graphs (DAGs) with latent (selection) variables. These graphical objects encode information about ancestral relations and d-separations of the DAGs they…

Discrete Mathematics · Computer Science 2025-09-25 Binghua Yao , Joris M. Mooij

There is strong interest in developing mathematical methods that can be used to understand complex neural networks used in image analysis. In this paper, we introduce techniques from Linear Algebra to model neural network layers as maps…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Rebecca Pattichis , Marios S. Pattichis

Advances in deep learning models have revolutionized the study of biomolecule systems and their mechanisms. Graph representation learning, in particular, is important for accurately capturing the geometric information of biomolecules at…

Quantitative Methods · Quantitative Biology 2023-04-07 Xinye Xiong , Bingxin Zhou , Yu Guang Wang

Reconciling a gene tree with a species tree is an important task that reveals much about the evolution of genes, genomes, and species, as well as about the molecular function of genes. A wide array of computational tools have been devised…

Populations and Evolution · Quantitative Biology 2012-12-11 Yun Yu , Luay Nakhleh

Split networks are a popular tool for the analysis and visualization of complex evolutionary histories. Every collection of splits (bipartitions) of a finite set can be represented by a split network. Here we characterize which collection…

Populations and Evolution · Quantitative Biology 2015-09-22 Monika Balvočiūtė , David Bryant , Andreas Spillner

A wide range of applications and research has been done with genome-scale metabolic models. In this work we describe a methodology for comparing metabolic networks constructed from genome-scale metabolic models and how to apply this…

Molecular Networks · Quantitative Biology 2026-02-06 D. Gamermann , A. Montagud , J. A. Conejero , P. F. de Córdoba , J. F. Urchieguía

Distance-based phylogenetic algorithms attempt to solve the NP-hard least squares phylogeny problem by mapping an arbitrary dissimilarity map representing biological data to a tree metric. The set of all dissimilarity maps is a Euclidean…

Populations and Evolution · Quantitative Biology 2013-07-24 Ruth Davidson , Seth Sullivant

Systematic relations between multiple objects that occur in various fields can be represented as networks. Real-world networks typically exhibit complex topologies whose structural properties are key factors in characterizing and further…

Physics and Society · Physics 2021-04-09 Yoshihisa Tanaka , Ryosuke Kojima , Shoichi Ishida , Fumiyoshi Yamashita , Yasushi Okuno

We study systems of linear and semilinear mappings considering them as representations of a directed graph $G$ with full and dashed arrows: a representation of $G$ is given by assigning to each vertex a complex vector space, to each full…

Representation Theory · Mathematics 2017-04-21 Tatiana Klimchuk , Dmitry Kovalenko , Tetiana Rybalkina , Vladimir V. Sergeichuk

Biological systems and processes are networks of complex nonlinear regulatory interactions between nucleic acids, proteins, and metabolites. A natural way in which to represent these interaction networks is through the use of a graph. In…

Molecular Networks · Quantitative Biology 2023-01-04 Jacob Rast

We investigate parameterized algorithms for computing the average-tree phylogenetic diversity (APD) in rooted phylogenetic networks, studying the problem under different structural parameters that capture the deviation of a network from a…

Data Structures and Algorithms · Computer Science 2026-05-01 Leo van Iersel , Mark Jones , Jannik Schestag , Celine Scornavacca , Mathias Weller

Arboreal networks are multi-rooted phylogenetic networks whose underlying graph is a tree. We give an encoding of stack-free arboreal networks in terms of triplets and the novel concept of a duet. This yields a polynomial time algorithm to…

Discrete Mathematics · Computer Science 2026-05-05 Katharina T. Huber , Katherine St. John

Machine learning algorithms using deep architectures have been able to implement increasingly powerful and successful models. However, they also become increasingly more complex, more difficult to comprehend and easier to fool. So far, most…

Machine Learning · Computer Science 2020-08-20 Alexander Schulz , Fabian Hinder , Barbara Hammer

This article discusses how concepts and methods of complex networks can be applied to real-time imaging and computer vision. After a brief introduction of complex networks basic concepts, their use as means to represent and characterize…

Computer Vision and Pattern Recognition · Computer Science 2007-05-23 Luciano da Fontoura Costa

Phylogenetic networks are a special type of graph which generalize phylogenetic trees and that are used to model non-treelike evolutionary processes such as recombination and hybridization. In this paper, we consider {\em unrooted}…

Combinatorics · Mathematics 2025-05-21 Katharina T. Huber , Simone Linz , Vincent Moulton