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The ability to train ever-larger neural networks brings artificial intelligence to the forefront of scientific and technical discoveries. However, their exponentially increasing size creates a proportionally greater demand for energy and…

Many vertebrate motor and sensory systems decussate, or cross the midline to the opposite side of the body. The successful crossing of millions of axons during development requires a complex of tightly controlled regulatory processes.…

Neurons and Cognition · Quantitative Biology 2024-05-14 Troy Shinbrot , Wise Young

Neuroscience and Artificial Intelligence (AI) have made impressive progress in recent years but remain only loosely interconnected. Based on a workshop convened by the National Science Foundation in August 2025, we identify three…

Sequential activation of neurons is a common feature of network activity during a variety of behaviors, including working memory and decision making. Previous network models for sequences and memory emphasized specialized architectures in…

Neurons and Cognition · Quantitative Biology 2016-03-16 Kanaka Rajan , Christopher D Harvey , David W Tank

Cell biomechanics involve a great number of complex phenomena that are fundamental to the evolution of life itself and other associated processes, ranging from the very early stages of embryo-genesis to the maintenance of damaged structures…

Computer Vision and Pattern Recognition · Computer Science 2025-09-09 Juan Olalla-Pombo , Alberto Badías , Miguel Ángel Sanz-Gómez , José María Benítez , Francisco Javier Montáns

Physical neural networks are artificial neural networks that mimic synapses and neurons using physical systems or materials. These networks harness the distinctive characteristics of physical systems to carry out computations effectively,…

Applied Physics · Physics 2024-08-13 Weichao Yu , Hangwen Guo , Jiang Xiao , Jian Shen

The synchronized activity of neuronal populations can lead to pathological over-synchronization in conditions such as epilepsy and Parkinson disease. Such states can be desynchronized by brief electrical pulses. But when the underlying…

Neurons and Cognition · Quantitative Biology 2026-03-16 Ramón Guevara , Marco Zenari , Giorgio Nicoletti , Elisa Marini , Samir Suweis , Sandro Azaele , Marco Formentin

Bayesian Networks may be appealing for clinical decision-making due to their inclusion of causal knowledge, but their practical adoption remains limited as a result of their inability to deal with unstructured data. While neural networks do…

Machine Learning · Computer Science 2022-11-16 Paloma Rabaey , Cedric De Boom , Thomas Demeester

Interfacing artificial functional materials and living neuronal tissues is at the forefront of bio-nano-technology. Attempts have been so far based onto microscale processing of metals and inorganic semiconductors as electrodes or…

Multiple sclerosis lesion activity segmentation is the task of detecting new and enlarging lesions that appeared between a baseline and a follow-up brain MRI scan. While deep learning methods for single-scan lesion segmentation are common,…

Computer Vision and Pattern Recognition · Computer Science 2020-06-02 Nils Gessert , Marcel Bengs , Julia Krüger , Roland Opfer , Ann-Christin Ostwaldt , Praveena Manogaran , Sven Schippling , Alexander Schlaefer

We present a recent theory for nerve pulse propagation and anesthesia and argue that both nerve activity and the action of anesthetics can be understood on the basis of simple physical laws. It was found experimentally that biological…

Biological Physics · Physics 2020-08-10 Thomas Heimburg

Synthetic reverberating activity patterns are experimentally generated by stimulation of a subset of neurons embedded in a spontaneously active network of cortical cells in-vitro. The neurons are artificially connected by means of…

Neurons and Cognition · Quantitative Biology 2012-03-27 Roni Vardi , Avner Wallach , Evi Kopelowitz , Moshe Abeles , Shimon Marom , Ido Kanter

The artificial axon is an excitable node built with the basic biomolecular components and supporting action potentials. Here we demonstrate coincidence firing (the AND operation) and other basic electrophysiology features such as increasing…

Biological Physics · Physics 2017-11-22 Hector Vasquez , Giovanni Zocchi

Neural network training is usually accomplished by solving a non-convex optimization problem using stochastic gradient descent. Although one optimizes over the networks parameters, the main loss function generally only depends on the…

Machine Learning · Computer Science 2023-02-10 Julius Berner , Dennis Elbrächter , Philipp Grohs

Inspired by the diversity of biological neurons, quadratic artificial neurons can play an important role in deep learning models. The type of quadratic neurons of our interest replaces the inner-product operation in the conventional neuron…

Machine Learning · Computer Science 2023-09-12 Feng-Lei Fan , Mengzhou Li , Fei Wang , Rongjie Lai , Ge Wang

It has been widely assumed that a neural network cannot be recovered from its outputs, as the network depends on its parameters in a highly nonlinear way. Here, we prove that in fact it is often possible to identify the architecture,…

Machine Learning · Computer Science 2020-02-25 David Rolnick , Konrad P. Kording

Spintronic technology is emerging as a direction for the hardware implementation of neurons and synapses of neuromorphic architectures. In particular, a single spintronic device can be used to implement the nonlinear activation function of…

The human brain can be considered to be a graphical structure comprising of tens of billions of biological neurons connected by synapses. It has the remarkable ability to automatically re-route information flow through alternate paths in…

Machine Learning · Computer Science 2022-08-26 Hang Li , Qadeer Khan , Volker Tresp , Daniel Cremers

Deep neural networks have become a pervasive tool in science and engineering. However, modern deep neural networks' growing energy requirements now increasingly limit their scaling and broader use. We propose a radical alternative for…

Machine Learning · Computer Science 2022-01-31 Logan G. Wright , Tatsuhiro Onodera , Martin M. Stein , Tianyu Wang , Darren T. Schachter , Zoey Hu , Peter L. McMahon

Here we propose a generic mechanism - networked buffering - for generating robust traits in complex systems that requires two basic conditions to be satisfied: 1) agents are versatile enough to perform more than one single functional role…

Adaptation and Self-Organizing Systems · Physics 2011-12-15 James M Whitacre , Axel Bender